Protein electrophoresis separates the proteins in a patient sample by their size and charge and allows for the detection of abnormal monoclonal proteins. Immunofixation electrophoresis is used to determine the type of monoclonal protein present. Both methods are technically challenging and require interpretation by a qualified laboratory professional.
Occasionally, anomaly such as immunoglobulin complexes or temperature sensitive cryoglobulins distort the protein separation and prevent accurate interpretation of test results.
A case study published in the July 2019 issue of the Journal of Applied Laboratory Medicine describes a patient whose monoclonal protein was not identifiable by routine protein electrophoresis and immunofixation methods. The Case Report suggests steps that laboratories may take to reduce artifacts and identify monoclonal proteins accurately.
]]>Protein electrophoresis separates the proteins in a patient sample by their size and charge and allows for the detection of abnormal monoclonal proteins. Immunofixation electrophoresis is used to determine the type of monoclonal protein present. Both methods are technically challenging and require interpretation by a qualified laboratory professional.
Occasionally, anomaly such as immunoglobulin complexes or temperature sensitive cryoglobulins distort the protein separation and prevent accurate interpretation of test results.
A case study published in the July 2019 issue of the Journal of Applied Laboratory Medicine describes a patient whose monoclonal protein was not identifiable by routine protein electrophoresis and immunofixation methods. The Case Report suggests steps that laboratories may take to reduce artifacts and identify monoclonal proteins accurately.
]]>"False Positive Carbamazepine Results by Gas-Chromatography Mass Spectrometry and VITROS 5600 Following a Massive Oxcarbazepine Ingestion" was published in the July 2018 issue of The Journal of Applied Laboratory Medicine. The case study highlights unique circumstances that affected both screening and confirmatory methods for urine drug testing.
]]>"False Positive Carbamazepine Results by Gas-Chromatography Mass Spectrometry and VITROS 5600 Following a Massive Oxcarbazepine Ingestion" was published in the July 2018 issue of The Journal of Applied Laboratory Medicine. The case study highlights unique circumstances that affected both screening and confirmatory methods for urine drug testing.
]]>"Keeping Up with Fentanyl: Failure to Do So Is Not an Option" was published in the July 2018 issue of The Journal of Applied Laboratory Medicine. This manuscript surveys the current landscape of available laboratory testing for detection of fentanyl and fentanyl analogs. Additionally, point-of-care testing of fentanyl and its analogs for the treatment of substance abuse disorder is discussed.
]]>"Keeping Up with Fentanyl: Failure to Do So Is Not an Option" was published in the July 2018 issue of The Journal of Applied Laboratory Medicine. This manuscript surveys the current landscape of available laboratory testing for detection of fentanyl and fentanyl analogs. Additionally, point-of-care testing of fentanyl and its analogs for the treatment of substance abuse disorder is discussed.
]]>Automated Laboratories: When Technology Needs a Human Touch was published in the May 2018 issue of the Journal of Applied Laboratory Medicine. This work reflects on one lab's experience with a challenging implementation of laboratory automation. Several unanticipate outcomes were encountered that required investigation to improve laboratory turnaround time.
]]>Automated Laboratories: When Technology Needs a Human Touch was published in the May 2018 issue of the Journal of Applied Laboratory Medicine. This work reflects on one lab's experience with a challenging implementation of laboratory automation. Several unanticipate outcomes were encountered that required investigation to improve laboratory turnaround time.
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This complicates the interpretation by clinicians of urine drug tests that are often administered to patients prescribed opioids. Further, although opioid addiction is a worldwide problem, only some of the individuals exposed to these drugs become addicted to them.
A mini-review titled "The Pharmacogenetics of Opioid Use and Implications for Pain Management" published in the January 2018 special issue of JALM on Laboratory Support of Pain Management discusses these complex topics.
This complicates the interpretation by clinicians of urine drug tests that are often administered to patients prescribed opioids. Further, although opioid addiction is a worldwide problem, only some of the individuals exposed to these drugs become addicted to them.
A mini-review titled "The Pharmacogenetics of Opioid Use and Implications for Pain Management" published in the January 2018 special issue of JALM on Laboratory Support of Pain Management discusses these complex topics.
]]>However, the normal concentration of donor-derived cell-free DNA in successful kidney transplant patients has not been determined. An article titled "Biological Variation of Donor-Derived Cell-Free DNA in Renal Transplant Recipients: Clinical Implications" published in the November 2017 issue of JALM, determined the biological variation and reference intervals of this biomarker in this patient population to aid in discrimination between rejection versus no rejection in kidney transplant patients
]]>However, the normal concentration of donor-derived cell-free DNA in successful kidney transplant patients has not been determined. An article titled "Biological Variation of Donor-Derived Cell-Free DNA in Renal Transplant Recipients: Clinical Implications" published in the November 2017 issue of JALM, determined the biological variation and reference intervals of this biomarker in this patient population to aid in discrimination between rejection versus no rejection in kidney transplant patients
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