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The association between Gestational Diabetes and Postpartum Depression: A Systematic Review and Meta-analysis.
Diabetes Res Clin Pract. 2019 Feb 05;:
Authors: Azami M, Badfar G, Solemani A, Rahmati S
AIMS: Postpartum period is a critical period for mothers, which is often accompanied by increased risk of depression. Many studies have evaluated the relationship between gestational diabetes (GDM) and postpartum depression (PPD), but contradictory results have been reported. Therefore, the present study was conducted to investigate the relationship between gestational diabetes and Postpartum Depression.
METHODS: This systematic review and meta-analysis was conducted based on PRISMA Guideline. We searched all the relevant epidemiological studies in international databases of Scopus, PubMed, Science Direct, Embase, Web of Science, CINAHL, Cochrane, EBSCO, and Google scholar search engine using the MeSH Keywords in English without time limit. The heterogeneity of the studies was calculated using the I2 index and Cochran's Q test. The results of the study were analyzed using the random effects model and Comprehensive Meta-Analysis Software Version 2. Relative risk (RR) and 95% confidence interval (CI) were extracted from each study.
RESULTS: A total of 18 studies with a sample size of 2,370,958 were reviewed. Meta-analysis results showed that gestational diabetes significantly increased the risk of Postpartum Depression, and RR was 1.59 (95% CI: 1.22-2.07, p = 0.001). The relative risk for 15 cohort studies, 2 cross-sectional studies and 1 case-control study was 1.67 (95% CI: 1.22-2.28), 1.37 (95% CI: 0.91-2.05), and 1.29 (95% CI: 0.98-1.68), respectively.
CONCLUSIONS: gestational diabetes can be a risk factor for Postpartum Depression. Therefore, Postpartum Depression examination in pregnant women with gestational diabetes seems to be necessary.
PMID: 30735772 [PubMed - as supplied by publisher]