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          Analytical solutions for a soil vapor extraction model that incorporates gas phase dispersion and molecular diffusion      Cache   Translate Page      
To greatly simplify their solution, the equations describing radial advective/dispersive transport to an extraction well in a porous medium typically neglect molecular diffusion. While this simplification is appropriate to simulate transport in the saturated zone, it can result in significant errors when modeling gas phase transport in the vadose zone, as might be applied when simulating a soil vapor extraction (SVE) system to remediate vadose zone contamination. A new analytical solution for the equations describing radial gas phase transport of a sorbing contaminant to an extraction well is presented. The equations model advection, dispersion (including both mechanical dispersion and molecular diffusion), and rate-limited mass transfer of dissolved, separate phase, and sorbed contaminants into the gas phase. The model equations are analytically solved by using the Laplace transform with respect to time. The solutions are represented by confluent hypergeometric functions in the Laplace domain. The Laplace domain solutions are then evaluated using a numerical Laplace inversion algorithm. The solutions can be used to simulate the spatial distribution and the temporal evolution of contaminant concentrations during operation of a soil vapor extraction well. Results of model simulations show that the effect of gas phase molecular diffusion upon concentrations at the extraction well is relatively small, although the effect of concentrations in space is significant. This study provides a tool that can be useful in designing SVE remediation strategies, as well as verifying numerical models used to simulate SVE system performance.
          Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial.      Cache   Translate Page      
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Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial.

Lancet. 2018 Oct 03;:

Authors: Bohula EA, Scirica BM, Inzucchi SE, McGuire DK, Keech AC, Smith SR, Kanevsky E, Murphy SA, Leiter LA, Dwyer JP, Corbalan R, Hamm C, Kaplan L, Nicolau JC, Ophuis TO, Ray KK, Ruda M, Spinar J, Patel T, Miao W, Perdomo C, Francis B, Dhadda S, Bonaca MP, Ruff CT, Sabatine MS, Wiviott SD, CAMELLIA-TIMI 61 Steering Committee Investigators

Abstract
BACKGROUND: There is a direct relationship between bodyweight and risk of diabetes. Lorcaserin, a selective serotonin 2C receptor agonist that suppresses appetite, has been shown to facilitate sustained weight loss in obese or overweight patients. We aimed to evaluate the long-term effects of lorcaserin on diabetes prevention and remission.
METHODS: In this randomised, double-blind, placebo-controlled trial done in eight countries, we recruited overweight or obese patients (body-mass index ≥27 kg/m2) with or at high risk for atherosclerotic vascular disease. Eligible patients were aged 40 years or older; patients at high risk for atherosclerotic vascular disease had to be aged 50 years or older with diabetes and at least one other risk factor. Patients were randomly assigned to receive either lorcaserin (10 mg twice daily) or matching placebo. Additionally, all patients had access to a standardised weight management programme based on lifestyle modification. The prespecified primary metabolic efficacy endpoint of time to incident diabetes was assessed in patients with prediabetes at baseline. The prespecified secondary outcomes for efficacy were incident diabetes in all patients without diabetes, achievement of normoglycaemia in patients with prediabetes, and change in glycated haemoglobin (HbA1c) in patients with diabetes. Hypoglycaemia was a prespecified safety outcome. Analysis was by intention to treat, using Cox proportional hazard models for time-to-event analyses. This trial is registered with ClinicalTrials.gov, number NCT02019264.
FINDINGS: Between Feb 7, 2014, and Nov 20, 2015, 12 000 patients were randomly assigned to lorcaserin or placebo (6000 patients in each group) and followed up for a median of 3·3 years (IQR 3·0-3·5). At baseline, 6816 patients (56·8%) had diabetes, 3991 (33·3%) prediabetes, and 1193 (9·9%) normoglycaemia. At 1 year, patients treated with lorcaserin had a net weight loss beyond placebo of 2·6 kg (95% CI 2·3-2·9) for those with diabetes, 2·8 kg (2·5-3·2) for those with prediabetes, and 3·3 kg (2·6-4·0) for those with normoglycaemia (p<0·0001 for all analyses). Lorcaserin reduced the risk of incident diabetes by 19% in patients with prediabetes (172 [8·5%] of 2015 vs 204 [10·3%] of 1976; hazard ratio 0·81, 95% CI 0·66-0·99; p=0·038) and by 23% in patients without diabetes (174 [6·7%] of 2615 vs 215 [8·4%] of 2569; 0·77, 0·63-0·94; p=0·012). Lorcaserin resulted in a non-significant increase in the rate of achievement of normoglycaemia in patients with prediabetes (185 [9·2%] vs 151 [7·6%]; 1·20, 0·97-1·49; p=0·093). In patients with diabetes, lorcaserin resulted in a reduction of 0·33% (95% CI 0·29-0·38; p<0·0001) in HbA1c compared with placebo at 1 year from a mean baseline of 53 mmol/mol (7·0%). In patients with diabetes at baseline, severe hypoglycaemia with serious complications was rare, but more common with lorcaserin (12 [0·4%] vs four [0·1%] events; p=0·054).
INTERPRETATION: Lorcaserin decreases risk for incident diabetes, induces remission of hyperglycaemia, and reduces the risk of microvascular complications in obese and overweight patients, supporting the role of lorcaserin as an adjunct to lifestyle modification for chronic management of weight and metabolic health.
FUNDING: Eisai.

PMID: 30293771 [PubMed - as supplied by publisher]


          BCA Pink Ribbon Picks: The Better Skin Co.’s Limited Edition Pink Gold Amaze Balm      Cache   Translate Page      
The Better Skin Co. is donating 100% of the October proceeds from their Limited Edition Pink Gold Amaze Balm to theYoung Survival Coalition. Nourish your skin with Ultra Rich Amaze Balm and it will love you. Oil of Coconut, Avocado, Sunflower, Evening Primrose and Sea Buckthorn create a silky-smooth slip. Shea Butter, Lanolin and Beeswax assist in creating the creamy goodness that will excite and satisfy your skin. Scented with a hint of grapefruit, Amaze Balm is all kinds of AMAZING! Once you try it, you’ll become obsessed with keeping this thickly textured moisturizer in your arsenal of beauty must-haves this fall.Use it as needed, when needed; $36, www.TheBetterSkinCo.com.   KEY BENEFITS • Ultra hydrating & nourishing • Reduces puffiness • Diminishes the appearance of fine lines and wrinkles • Excellent as a sleeping mask • Decreases hyper-pigmentation, creating brighter skin
          Comment on Chronic lyme and high blood pressure by Remon      Cache   Translate Page      
I too have hypertensive complaints which started when I was a kid ( I think it started after I got bitten but it was also made worse by the traumas i faced afterwards). I too have bartonella. luckily my MRI ruled out brain lesions.. despite that I FEEL this horrible brain pressure almost What I recommend is to buy a SPOOKY 2 Rife machine. It is quite affordable and can really kill of the spirochetes (but its not an easy fast route).
          Comment on 110 Drawings and Paintings by J.R.R. Tolkien: Of Middle-Earth and Beyond by Dawn Campbell      Cache   Translate Page      
Click on the third hyperlink in the first paragraph under the first picture...
          Municipal Elections -2018: 1029 candidates in fray for 263 Wards going to polls in Phase-II: CEO      Cache   Translate Page      

SRINAGAR, OCTOBER 09(KMW): The Chief Electoral Officer (CEO), J&K, Shaleen Kabra this evening said that in the 2nd Phase of Municipal Polls-2018 voting will take place at 544 polling stations across the State tomorrow on 10 October 2018. The polling time, he said will be from 6.00 am to 4.00 pm. He said 270 polling stations have been designated for voting in Kashmir Division and 274 in Jammu Division. The CEO said 1029 candidates are in the fray for 263 Municipal Wards including 49 in Kashmir and 214 in Jammu, going to polls in Phase-II. He said 881 candidates are in the fray in Jammu division and 148 in Kashmir division for Phase-II. “In the areas going to polls tomorrow, the total electorate is 346980, with 128104 in Jammu Division belonging to 18 Municipal bodies and 218876 in Kashmir Division of 5 Municipal bodies,”he said and added that Additional poll staff is also being deployed at the polling stations with larger number of electors. The CEO said that Basic Minimum Facilities (BMF) have been ensured in all the polling stations across the State for voting. He said Photo Voter Slips have already been distributed among the voters to inform them of their polling station. Kabra said senior government officers have been appointed as General Observers to oversee the smooth, fair and orderly conduct of polls. “Expenditure Observers are also keeping a watch on the expenditure by the candidates,” he said and added that for the poll day Micro Observers have been deployed in polling stations, particularly those considered sensitive/ hypersensitive. “Besides, the Zonal and Sector Magistrates have been deployed to ensure smooth conduct of polls as well as monitoring the entire process,” CEO said and added that the Deputy Commissioners are undertaking Videography of all critical events related to the poll process. Kabra said Control Rooms have been established in all the Municipal Bodies across the State to respond promptly to any complaints of violation of the Model Code of Conduct (MCC) as also to disseminate information to the public. He said adequate security arrangements have been made for smooth conduct of polling across the State. He said the government has also declared holiday on the day of poll in the municipal areas going to polls so as to enable the voters to cast their vote. He said as per standing guidelines, the Central Government offices shall not be closed but the employees who are electors of the poll going wards and desire to exercise their franchise shall be offered reasonable facility- by way of coming late to office / allowed to leave office early / short absence. The CEO urged voters to exercise their right to franchise in order to choose their local self-government to address to their local needs. Pertinently, Municipal Elections-2018 are being held in four phases, covering 79 municipal bodies with an electorate of about 17 lakh. A total of 3372 nominations have been filed for 1145 wards. Days of poll are 8th, 10th, 13th and 16th October for these four phases.

The post Municipal Elections -2018: 1029 candidates in fray for 263 Wards going to polls in Phase-II: CEO appeared first on Kashmir Media Watch.


          Harcourt Matthews Ltd: Hyperion Systems Analyst      Cache   Translate Page      
£40,000 per annum: Harcourt Matthews Ltd: Supporting an international portfolio of blue chip clients, this market-leading Business Services group has built an enviable reputation for excellence, service and delivering a broad range of business solutions to global customers. On-going development o Hatfield
          Harcourt Matthews Ltd: Finance Systems Analyst - Hyperion      Cache   Translate Page      
£60,000 per annum: Harcourt Matthews Ltd: Supporting an international portfolio of blue chip clients, this market-leading Business Services group has built an enviable reputation for excellence, service and delivering a broad range of business solutions to global customers. On-going development o Hatfield
          Freelance Journalist - Block Talk - Calgary, AB      Cache   Translate Page      
Journalist who is interested in creating local content, serving hyper local Calgary communities. Preference given to someone with journalism experience....
From Indeed - Tue, 09 Oct 2018 20:09:16 GMT - View all Calgary, AB jobs
          QNAP TVS-882ST3 - Jelenlegi ára: 1 199 000 Ft      Cache   Translate Page      
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Flex Memory Access✔ Tétlen állapotok✔ Graphics & IMC lithography14 nmIntel Smart Response Technology verziója1 Intel Secure Key Technology verziója1 Intel Small Business Advantage (SBA) verziója1 Intel TSX-NI verziója1 A PCI Expressz sávok maximális száma16 A processzor által támogatott memóriacsatornákDuplaA processzor által támogatott memóriatípusokDDR3L-SDRAM / LPDDR3-SDRAM / DDR4-SDRAMProcesszorProcesszormodellI7-6700HQProcesszorkódSR2FQLéptetőR0Tjunction100 °CThermal Design Power (TDP)45 WA processzor frekvenciája2, 6 GHzA processzor növelési frekvenciája3, 5 GHzProcesszormagok4 Processzorszálak8 A buszrendszer sebessége8 GT/másodpercProcesszor gyorsítótár6 MBA processzor gyorsítótárának típusaSmart CacheProcesszor litográfia14 nmProcesszor üzemmódok64 -bitA processzor kódneveSkylakeProcesszor sorozatIntel Core i7-6700 Mobile seriesPCI-expressz csatlakozók verziója3 PCI Express konfigurációk1 x 16. 2 x 8. 1 x 8 x 2 x 4Konfliktusmentes processzor✔ Busz típusaDMI3CPU konfiguráció (max. )1 A processzor csomag mérete42 A processzor által támogatott maximális belső memória64 GBProcesszor ARK ID88967 A processzor által támogatott memória sávszélesség (max. )34, 1 GB/sProcessszorcsaládIntel Core i7MemóriaMemória bővítőhelyek2RAM kapacitás16 GBRAM típusaDDR4Maximális RAM támogatás32 GBFlash memória mérete512 MBTartozékokCsavarok száma32 Kábelek mellékelveAC / LAN (RJ-45)TeljesítményTípusNASTámogatott Windows operációs rendszerekWindows 10 Education / Windows 10 Education x64 / Windows 10 Enterprise / Windows 10 Enterprise x64 / Windows 10 Home / Windows 10 Home x64 / Windows 10 IOT Core / Windows 10 Pro / Windows 10 Pro x64 / Windows 7 Enterprise / Windows 7 Enterprise x64 / Windows 7 Home Basic / Windows 7 Home Basic x64 / Windows 7 Home Premium / Windows 7 Home Premium x64 / Windows 7 Professional / Windows 7 Professional x64 / Windows 7 Starter / Windows 7 Starter x64 / Windows 7 Ultimate / Windows 7 Ultimate x64 / Windows 8 / Windows 8 Enterprise / Windows 8 Enterprise x64 / Windows 8 Pro / Windows 8 Pro x64 / Windows 8 x64Támogatott Mac operációs rendszerekMac OS X 10. 10 Yosemite / Mac OS X 10. 11 El Capitan / Mac OS X 10. 12 Sierra / Mac OS X 10. 7 Lion / Mac OS X 10. 8 Mountain Lion / Mac OS X 10. 9 MavericksIntegrált kapcsoló✔ EszközosztályKis- és középvállalkozásokTelepített operációs rendszerQNAP Turbo SystemBiztonsági mentés jellemzőiFelhő / iSCSI LUNAz operációs rendszer verziója4, 3 Biztonsági algoritmusok256 ? 2 HTTPS, SSH, SSL/TLSBeépített iTunes kiszolgáló✔ Beépített FTP kiszolgáló✔ Rendszernapló✔ MappamegosztásCIFS / AFP / FTP / WebDAVTámogatott Linux operációs rendszerek✔ Macintosh rendszerrel kompatibilis✔ Backup funkció✔ S. 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HD Graphics 530A fedélzeti grafikus adapter alapfrekvenciája350 MhzMaximális fedélzeti grafikus adapter memória1, 7 GBA támogatott kijelzők száma (fedélzeti grafika)3 A fedélzeti grafikus adapter dinamikus frekvenciája (max. )1050 MhzAlaplapProcesszorfoglalatBGA 1440Csomagolás tartalmaGyorstelepítési útmutató✔
QNAP TVS-882ST3
Jelenlegi ára: 1 199 000 Ft
Az aukció vége: 2018-10-27 10:37
          QNAP TVS-1282 - Jelenlegi ára: 1 179 000 Ft      Cache   Translate Page      
TípusNASSzínfeketeProcesszorProcesszormodelli7-6700Processzor órajele4000000000 MhzProcesszormagok száma4 Processzor package size37. 5ProcesszorkódSR2BTRendszer bus sebesség8 GT/sProcesszor cache típusaSmart CacheProcesszorszálak száma8 LéptetőR0Bus típusDMI3Processzor kódnévSkylakeProcesszor által támogatott maximális belső memória64 GBProcesszorsorozatIntel Core i7-6700 Desktop seriesThermal Design Power (TDP)65 WConflict Free processor✔ Kihúzható füles tok71 °CCPU configuration (max)1 Processzor ARK ID88196PCI Express csatornák maximális száma16 Processzor gyártási technológiája14 nmProcesszor üzemmódok64 bitSkálázhatóság1SProcesszor által támogatott memória sávszélesség (max)34, 1 GB/sProcessszorcsaládIntel Core i7Processzor cache mérete8 MBMemóriaBelső memória mérete32 GBTámogatott maximális memória32 GBMemória bővítőhelyek4Belső memória típusaDDR4Flash memória mérete512 MBOperációs rendszerOperációs rendszer4. 2KompatibilitásTámogatott fájlrendszerekFAT32 / HFS+ / NTFS / ext3 / ext4Támogatott merevlemezHDD / SSDTámogatott Windows verziókWindows 10 Education / Windows 10 Education x64 / Windows 10 Enterprise / Windows 10 Enterprise x64 / Windows 10 Home / Windows 10 Home x64 / Windows 10 Pro / Windows 10 Pro x64 / Windows 7 Enterprise / Windows 7 Enterprise x64 / Windows 7 Home Basic / Windows 7 Home Basic x64 / Windows 7 Home Premium / Windows 7 Home Premium x64 / Windows 7 Professional / Windows 7 Professional x64 / Windows 7 Starter / Windows 7 Starter x64 / Windows 7 Ultimate / Windows 7 Ultimate x64 / Windows 8 / Windows 8 Enterprise / Windows 8 Enterprise x64 / Windows 8 Pro / Windows 8 Pro x64 / Windows 8 x64 / Windows 8. 1 / Windows 8. 1 Enterprise / Windows 8. 1 Enterprise x64 / Windows 8. 1 Pro / Windows 8. 1 Pro x64 / Windows 8. 1 x64CsatlakozókUSB portVanIntegrált GPUAlapfrekvencia350 MhzDinamikus frekvencia (max)1150 MhzTámogatott kijelzők száma3 OpenGL verzió4, 4 ModellIntel? HD Graphics 530ID1912PortokHDMI portok száma3 Ethernet LAN (RJ-45) portok száma4 TartozékokGyors telepítési útmutató✔ Csavarok száma28 Kábelek mellékelveAC / LAN (RJ-45)TeljesítményIntegrált kapcsoló✔ Device classSmall & Medium BusinessBackup funkció✔ Backup jellemzőkiSCSI LUNS. M. A. R. T. támogatás✔ Újraindító gomb✔ Webalapú kezelés✔ Hozzáférési vezérlő lista (ACL)✔ Beépített iTunes server✔ Többnyelvű ügyfélszolgálat✔ Beépített FTP server✔ Támogatott böngészőMicrosoft Internet Explorer 10+ / Mozilla Firefox 8+ / Apple Safari 4+ / Google ChromeHot spare✔ Támogatott biztonsági algoritmus256-bit AES / FIPS 140-2 / HTTPS / SSH / SSL / TLSTámogatott szerver operációs rendszerekWindows Server 2003 / Windows Server 2008 / Windows Server 2008 R2 / Windows Server 2012 / Windows Server 2012 R2Támogatott Linux verziókVanTámogatott Mac operációs rendszer verziókMac OS X 10. 0 Cheetah / Mac OS X 10. 1 Puma / Mac OS X 10. 10 Yosemite / Mac OS X 10. 11 El Capitan / Mac OS X 10. 2 Jaguar / Mac OS X 10. 3 Panther / Mac OS X 10. 4 Tiger / Mac OS X 10. 5 Leopard / Mac OS X 10. 6 Snow Leopard / Mac OS X 10. 7 Lion / Mac OS X 10. 8 Mountain Lion / Mac OS X 10. 9 MavericksZajszint21, 6 dBProcesszor speciális funkciókGraphics & IMC lithography14 nmIntel Stable Image Platform Program (SIPP) verzió1. 00Nyugalmi állapot✔ Intel Small Business Advantage (SBA) verzió1. 00Hőmérséklet monitoring Technológia✔ Enhanced Intel SpeedStep Technológia✔ Intel Wireless Display (WiDi) Technológia✔ Execute Disable Bit✔ Intel Virtualization Technology for Directed I/O (VT-d)✔ Intel? Small Business Advantage (Intel? SBA)✔ Intel Hyper-Threading Technológia✔ Intel Stable Image Platform Program (SIPP)✔ Intel? Turbo Boost Technológia✔ Intel vPro Technológia✔ Intel? Quick Sync Video Technológia✔ Intel Clear Video HD Technológia✔ Intel? Insider? ✔ Intel AES New Instructions✔ Intel Trusted Execution Technológia✔ Intel Enhanced Halt State✔ Intel VT-x with Extended Page Tables (EPT)✔ Intel? Secure Key✔ Intel? OS Guard✔ Intel Clear Video Technológia✔ Intel Clear Video Technológia for MID✔ Intel 64✔ Intel Secure Key Technológia verzió1 Intel Virtualization Technológia (VT-x)✔ Intel TSX-NI verzió1. 00Thermal solution specificationPCG 2015CIntel? InTru? 3D Technology✔ Memory channels supported by processorDuplaMemory types supported by processorDDR3L-SDRAM / DDR4-SDRAMMemory voltage supported by processor1, 35 VTanúsítványokDLNA tanúsítvánnyal✔ TárolóegységTelepített tároló típusaNincsMeghajtó mérete6. 350000006477 / 8. 8900000090678 cmHot-swap meghajtó hely✔ Meghajtó interfészSerial ATA IIITámogatott meghajtók száma12 RAID-szintek273524 / 1 / 2 / 3 / 4 / 5 / 6 / JBODRAID támogatás✔ Ergonómia / FormatervezésGépház típusatoronyLED-kijelzőkHDD / SSD / StatusHűtés típusaAktívKijelző típusaLCDBeépített kijelző✔ Grafikus megjelenítésMaximális integrált grafikus memória1, 74 GBDirectX12. 0HűtésVentilátorok száma3 fanVentilátor átmérő8 cmEnergiamenedzsmentKimeneti áramerősség5 AAC bemeneti frekvencia50 / 60 HzAC adapter bemeneti feszültség100 ? 240 VEnergiakezelés✔ Környezeti feltételekÜzemi hőmérséklettartomány (T-T)0 - 40 °CRelatív üzemi páratartalom-tartomány5 - 95%KapcsolatUSB 3. 0 (3. 1 Gen 1) Type-A portok száma5HálózatiSCSI-támogatás✔ DHCP kliens✔ DHCP szerver✔ Link-aggregáció✔ LAN-ébresztési funkció✔ Támogatott hálózati protokollokCIFS / SMB / AFP (v3. 3) / NFS(v3) / FTP / FTPS / SFTP / TFTP / HTTP(S) / Telnet / SSH / iSCSI / SNMP / SMTP / and SMSCÓriáskeret támogatással1 LAN adatátviteli sebesség10 / 100 / 1000 Mbit/sEthernet/LAN csatlakozás✔ TápellátásTápegység helyebeépítettTápegységek száma1 Tápegység (PSU) kapacitás250 WAlaplapProcesszorfoglalatLGA 1151 (Socket H4)BővítőhelyekPCI Express verzió3. 0PCI Express konfiguráció2x8, 1x8+2x4, 1x16Méretek és súlySúly11. 6 kgSzélesség369, 9 mmMagasság23, 46 cmMélység319, 8 mmBiztonságJelszavas hitelesítés✔ Technikai részletekProgramtámogatásQfinder Pro / myQNAPcloud Connect / Qsync / NetBak / vSphere / Q? center Virtual Appliance / QNAP Snapshot Agent / QsnapBeépített UPnP AV médiaszerver✔ System log✔ Berregő (áramszaggató)✔ FunkciókMappamegosztásCIFS / SMBMegosztott mappák elérési jogainak kezelése✔ CsomagolásCsomagolás nettó súly13, 7 kg
QNAP TVS-1282
Jelenlegi ára: 1 179 000 Ft
Az aukció vége: 2018-10-27 10:36
          Getting Local Land Use Approvals Right      Cache   Translate Page      
Getting Local Land Use Approvals Right
October 9, 2018

What can California and its cities do to bring down the soaring costs of housing? Land entitlement, often lengthy and subject to review at several levels, is one process that could be reformed to speed up the construction of new housing and, in doing so, reduce costs.

Recently, researchers from Berkeley Law joined San Francisco Planning Department staff at a SPUR forum in San Francisco to discuss how state and city reforms might (or might not) streamline the approval processes. Berkeley Law researchers Eric Biber, Moira O’Neill and Giulia Gualco-Nelson summarized their findings so far from a multi-year study of land entitlement in five Bay Area cities: Redwood City, Oakland, Palo Alto, San Jose and San Francisco. San Francisco Planning Department staff members Elizabeth Watty, Jake Bintliff and Lisa Gibson presented several pilot programs they designed to accelerate and simplify building approvals, changes that staff can implement without having to wait for local or state legal reforms.

Categories of Review

A number of factors influence land use approval in a jurisdiction, which can cause drastically different approval processes among cities in the same region. The Berkeley Law team explained that all jurisdictions in their study used discretionary review, a process that applies an extra layer of local approval for a plan, on top of compliance with the existing planning and zoning code. Jurisdictions can choose different mechanisms to impose discretion, however. In the five cities Berkeley Law studied, these mechanisms include design review, architectural review, general plan compliance and others. This difference can make applications for development across the region more difficult, which can prolong construction timelines and increase the cost of a project.

The same goes for environmental review: Policymakers have wondered if the California Environmental Quality Act (CEQA), a state mandate designed to minimize the health and environmental risks of new development, hinders the development of housing projects across the state because review and appeals can prolong the approval process. The Berkeley Law study found that while all cities in the study use CEQA as part of discretionary review processes, the reviews themselves were completed inconsistently. The study found that very few housing developments were subject to CEQA lawsuits (2.5 percent of projects among the jurisdictions, amounting to 5.3 percent of total units), suggesting that CEQA review does not prolong approval timelines. However, representatives from the San Francisco Planning Department noted that although CEQA lawsuits may be uncommon in San Francisco, the threat of a CEQA lawsuit and the compromises that are made to avoid one does in fact hinder development.

Shortening Timelines

The Berkeley Law researchers also studied the relationship between the land use approval timeline and the number of units in a project. Their data show that smaller projects (five units or fewer) took the longest time to be approved, suggesting that factors besides scale of a project are at play, and that perhaps the local political context could influence building approvals through discretionary processes. The team explained that cities seek to maintain discretion in their processes so that they can approve development that will bring revenue and infrastructure to the city.

The Planning Department explained several modifications to their procedures that can help reduce building approval timelines and decrease overall project costs. Some of these included adding more staff, more collaboration among staff who are conducting different categories of review of the same project, and introducing methods to move projects toward approval without having to wait in line. They also hope to speed up the approval process for in-law or accessory dwelling units (ADUs) and modifications to single family homes and will set up a simplified administrative approval process for affordable housing projects. Jake Bintliff emphasized that even simple tweaks to departmental tasks can save staff time and help important housing projects break ground sooner.

Exploring New Ideas

Both Berkeley Law and the San Francisco Planning Department shared other ideas that could advance the construction of housing. One promising solution is California Assembly Bill 73, which would allow cities to create housing sustainability districts and receive financial incentives for doing so. Developments within a sustainability district would be automatically granted an initial environmental impact review and ministerial permits within 120 days. A sustainability district must be located within one half mile of public transit and, if established, will receive zoning incentive payments from the California Department of Housing and Community Development. The Berkeley Law panelists emphasized that in order for the state to create effective policy for all jurisdictions, legislators must have better access to data that shows what is actually happening in local land use approvals processes before making sweeping changes to CEQA and other regulations.

Berkeley Law will expand its research to Los Angeles, while the City of San Francisco will launch pilot and other preliminary measures within the department to see how they will affect approval timelines. Both groups hope these efforts can inform other cities in modifying their local approval procedures, as well as future statewide policy changes.


          Planet Coaster: World's Fair Pack (DLC) angekündigt      Cache   Translate Page      
Frontier Developments hat das World's Fair Pack für Planet Coaster angekündigt. Die Erweiterung wird am 16. Oktober 2018 für 10,99 Euro erscheinen. Der DLC umfasst zehn internationale Szenerien, zwei neue Coaster, 300 Bauelemente und mehr als 60 Landschaftselemente.
 
Das World's Fair Pack beinhaltet:
  • "Zehn neue, internationale Szenerien die von China, den USA, Frankreich, Marokko, Italien, Deutschland, Japan, Großbritannien, Mexiko und Spanien inspiriert wurden
  • Die neue Transport-Bahn: Polarity - eine fahrerlose magnetgetriebene Bahn
  • Den Jixxer und Intercepter: Ein duellierendes Duo, welches sich mit Motorrad-Wägen eine hyper-dynamische Verfolgungsjagd liefert - angefeuert durch einen Hochgeschwindigkeits-Hydraulik-Antrieb, starten die Motorräder auf einer Bahn mit zwei separaten Spuren ihr Rennen
  • Über 300 maßgeschneiderte Bauelemente mit kulturellen Requisiten, Beschilderungen, Zäunen und Pfaden decken die Erscheinungsbilder der zehn Länder ab"
 
Zusätzlich zum World's Fair Pack gibt es ein kostenloses Update auf Version 1.8 für alle Spieler. Es beinhaltet neue Restaurants, Verkaufsautomaten und einige Verbesserungen (zum Change-Log).

Weiter zum Video

          Comment on SummerJobs by M88      Cache   Translate Page      
Would you be eager about exchanging hyperlinks?
          Ramban, Udhampur, Kathua to go for ULB polls      Cache   Translate Page      
After successful completion of first phase polls of Urban Local Bodies election, Ramban, Udhampur and Kathua districts are all set to go for polls in the second phase tomorrow.As per officials, sealed Electronic Voting Machines (EVMs) and other election material for 18 polling stations of Ramban, Banihal and Batote Municipal Committees was handed over to Polling Officers and Polling Parties under the supervision of District Election Officer, Ramban, Showkat Aijaz Bhat at DC Office Complex, Ramban.The ULB polls are scheduled on October 10 in the district from 6 am to 4 pm.The DEO entrusted upon the Polling and other officers designated with the election duty to work with utmost dedication and devotion for successful completion of polls.Three candidates of Banihal MC have been elected unopposed, he added.SSP, Anita Sharma informed that a foolproof security arrangements being made for safe and hassle-free transportation of polling staff and material.Meanwhile District Election Officer, Kathua, Rohit Khajuria also finalized the preparedness for the Urban Local Body polls scheduled on tomorrow.Under the supervision of DEO, sealed EVMs and other election material were handed over to the Polling parties for 80 wards of one Municipal Council and 5 Municipal Committees of the district. Polling parties to far flung areas were also dispatched for the timely start of polling in such areas. The DEO informed that a total of 15 polling stations have been identified as hypersensitive and 53 as sensitive, for which full proof security system has been put in place for free and fair elections.Similarly under the supervision of District Election Officer, Udhampur Ravinder Kumar, the polling parties and micro Observers for Urban Local Body polls for 68 polling stations in 41 wards of one Municipal Council and two Municipal Committees of the Udhmapur district were dispatched along with EVMs and other election material amidst heavy security from Boys Government Degree College in Udhampur district.The DEO emphasized upon the Zonal and Sectoral Magistrates to evolve better coordination on the polling day i.e. October 10 to ensure effective polling.He further impressed upon them to ensure that polling parties should reach their respective polling stations on time.The DEO informed that a total of 55 ROs and ARO have been appointed for the successful conduct of the election process.District Election Officer, Kishtwar, Angrez Singh Rana on Tuesday visited various polling stations and inspected the preparedness and other requisite arrangements made for the Municipal elections.The DEO and other concerned Officers visited ITI Kishtwar where from Polling parties along with election material were dispatched. He also inspected the security arrangements and other pre-requisites related with election process.He directed the officers entrusted with election duties to remain extra vigilant and active to ensure free, fair and smooth conduct of election process.UNI VBH RJ 2240
          Why a Canadian basic income is inevitable      Cache   Translate Page      
Ontario’s recently cancelled basic-income pilot project, which intended to provide benefits for adults according to the same model, enrolled more working people than people already receiving income assistance. The need for a steady income among middle-class Canadians is accelerating as the labour-market changes. Silicon Valley hyperbole imagines robots replacing human labour, and that has happened for many factory jobs, but a much more likely outcome is that automation will change the way work is done.
          How I Use(d) Google+      Cache   Translate Page      

With yesterday’s news that Google+ is shutting down next August, I found myself looking again at my exported archive from the network. This time I was less interested in the format (which has changed since January – you can export as JSON instead of HTML if you choose, and it includes media now), and more […]

The post How I Use(d) Google+ appeared first on K-Squared Ramblings.


           “to B”的金矿还是BAT的?       Cache   Translate Page      

【编者按】本文回答了“为什么中国本土互联网没能诞生SAP、甲骨文一样擅长于服务B端(企业端)的伟大公司?”“B端市场的未来还会属于BAT吗?”两个问题,同时还详细介绍了BAT及其他主要玩家的B端业务布局。不过编者一直有个疑问,C端和B端市场玩法明显不同,2C的企业转型2B会成功吗?欢迎留言或私信交流。

本文转载“深响”,原作者亚澜,经亿欧整理编辑,供业内人事参考。


美团点评联合创始人王慧文曾在2013年的时候做了这样一件事——

他把美国科技业的公司和中国的公司拉了一个名单,试图从中寻找出在美国已经很厉害了但在中国还没有被真正做起来的产业。他发现了Salesforce,Workday,Oracle。

“他们基本占据科技业的另外一半……但是我们把这个放到中国来看的话,to B的公司居然找不到,基本上找不到,有活着的,但是活得很惨。”在一次内部讲话中,王慧文抛出了一个问题:为什么中国这些to B的企业活得这么惨呢?

的确,中国互联网的上一个十年是关于用户端(C端)的十年,人口红利、消费红利让各种商业模式创新迅速成长起来,消费级业务无论是盈利效果、创新难度还是企业品牌塑造都明显优于企业级服务。

与此同时,上一个十年,水大鱼大,依靠市场红利,业务的驱动并非步履维艰,企业对于提高效率的新工具、新方法的采用意愿并不高。那些昂贵的、短期效果不显著的企业服务自然也不好卖。百度李彦宏曾经在百度联盟大会上曾指出,过去中国劳动力成本很低,使用企业级软件的效应并没有起来,另外,很多传统企业的老板并不用电脑,不会用PC提升效率。

更何况,中国企业对于数据的安全性顾虑更多的,而美国数据立法相对成熟,对于企业服务类应用的数据安全性信任程度比中国高。

老牌企业服务公司用友、金蝶在过去很长一段时间里都不是聚光灯的所在,曾在2014、15年享受到资本“泡沫”的SaaS风口也没有真正地起飞,在中国诞生一家类似SAP、Oracle一样专注服务企业端(B端)的伟大公司,并不是一朝一夕的事情。

时机似乎到了。C端业务的瓶颈愈发明显、需求侧达到饱和,以企业为核心角色的供给侧改革势在必行。

但这并不是一个创业的机遇期。百度、腾讯、阿里早就在B端有所布局,其业务发展的深度广度远远超出行业的想象。如今他们不约而同地加大投入力度,进一步教育市场。至于京东、今日头条(字节跳动)、美团等公司,虽然在B端也有布局,但周密程度和BAT无法相比,而那些15年SaaS创业浪潮中的幸存者,也都只是专注于某一个非常细分的领域。

人们呼唤着“下一个十年,一切皆重来”,但事实上,下一个十年,to B业务前所未有的好时代,恐怕还是BAT的。

*注:Salesforce专注提供销售团队管理解决方案,Workday提供人力资源解决方案,Oracle(甲骨文)是全球最大的企业级软件公司。

BAT预谋已久的B计划

百度是BAT中最有to B气质的,其大部分营收也来自B端。定位为AI公司的百度,更多地会为企业提供无人驾驶汽车的、云的、整个AI应用生态平台的人工智能解决方案。

具体来看,百度未来的三个主要发展方向都是非常to B的:

第一,Apollo无人驾驶汽车生态。

Apollo计划,是针对汽车行业的自动驾驶开放平台。阿波罗平台包括一套完整的软硬件和服务体系,包括车辆平台、硬件平台、软件平台、云端数据服务等四大部分。这些都是To B的业务。

百度与金龙客车合作的、搭载了百度Apollo自动驾驶解决方案系统的全球首款L4级自动驾驶巴士“阿波龙”已经量产下线。同时,百度在“车”方面的企业级合作伙伴还包括戴姆勒、福特、博世、NVIDIA、Intel、BlackBerry等。

百度是一个供给端的平台,向包括运营商、汽车服务厂商、整车厂商、零部件厂商、芯片厂商等等在内的合作伙伴们提供“车”相关的服务。

第二,DuerOS度秘。

一直以来,度秘被理解为人机对话的接口,用来“唤醒万物”,但如果往深了看,DuerOS是目前中国唯一一个从硬件到框架,再到平台、开发生态、生态应用系统、终端硬件全覆盖的AI应用生态平台。这使得DuerOS的生态接入的吸纳性更高,能解决很多场景问题。

比如,在洲际酒店的“小度智慧客房”中。客人可以通过语音控制客房设备、播放音乐、询问天气、检索信息。AI时代,高端酒店正在借助新一代人机交互方式提升用户体验。

第三,ABC云

2017年,百度云推出了ABC战略,即AI人工智能、Big Data大数据、Cloud Computing云计算。在李彦宏看来,百度的“云”和其他传统的“云”服务是不一样的,它在每一个行业的应用都有智能的因素在里面。

在上个月的百度云智峰会上,百度云推出了AI to B平台,兼具深度学习、对话式搜索、自然语言处理等全面的AI能力,以及涵盖新零售、新制造、交通与公共安全等领域的解决方案。

以国内最大钢铁企业宝武集团与百度云在质检领域的合作为例,依托百度云质检云行业解决方案,通过机器视觉模型量化质检流程,为质检流程提供决策依据,在降低误报率的同时,提升作业效率。而百度云与优信二手车的合作,则是通过VR技术升级远程选车,并在线下门店内部署AI摄像头,通过人脸识别匹配购车信息,结合云平台与业务系统沉淀用户数据,为后续经营提供支撑。

现在百度云的行业版图已经覆盖了农业、工业制造业、金融服务业等领域,不光是简单地存储数据,而是通过AI能力为企业提供解决实际问题的解决方案。

百度在B端的野心其实李彦宏在2017年的世界互联网大会上就有透露,他当时分享了百度与连锁超市的合作,用人工智能的技术去提升超市里生鲜货品的效率,使得超市利润提升了20%,报损率降低了30%以上。

“人工智能对于B端的生态改变是非常明显的。无论是金融还是房产,无论是教育还是医疗,无论是能源还是物流等等,每一个方面,人工智能都有非常非常多的应用。”

简言之,百度的“B计划”是以AI切入,服务B端的每一个方面。

做云的远不只有百度,事实上,“云”正在成为BAT在企业服务领域的必争之地。

因为云确实是对企业有非常大的价值:一方面,云计算是公共服务,是可变成本,可按需使用,不再是固定资产投入,创业公司的成本可以降下来;另一方面,移动+云,相当于把IT服务在线化了,让技术门槛大大降低;而云与大数据的结合可以负能相当多的领域。

阿里是BAT中第一个提出做云计算业务的:2008年确定云计算战略,2009年成立阿里云公司。

就在前不久的2018杭州·云栖大会上,阿里云宣布成立全球交付中心,海公布了新一代云计算操作系统飞天2.0。在8月阿里巴巴公布的2019财年第一季度财报中,阿里云营收46.98亿元,为全球第三大IaaS服务提供商。

而云只是to B业务中的一部分。

《彭博商业周刊》对企业服务产品划分为三种主要流行模式:IaaS(Infrastructure as a Service,基础设施即服务)、PaaS(Platform as a Service,平台即服务)和SaaS(Software as a Service,软件即服务)。

云属于IaaS。阿里云的亮点在于,阿里巴巴拥有海量用户数据,这些数据叠加在云服务上会展现出极大的价值。同时,阿里本身的企业基因也是非常“to B”的,B2B业务起家就是面向着中小企业。

将自己现有生态客户转化为企业服务客户是非常顺畅的一条思路。比如,淘宝系厂商将自己的进销存系统放在阿里云上,顺理成章。从这个角度来说,阿里的先天优势很明显。

而阿里巴巴在SaaS服务领域的“钉钉”则是在SaaS的新战场上。

2014年阿里的“来往”在C端社交市场上全面溃败,团队转向企业服务市场,打造钉钉,争夺企业级市场的“入口”。2015年1月16日,钉钉发布1.0版本,DING功能上线。到今年3月31日,已有超过700万家企业组织在使用钉钉,注册用户过亿。

如此一来,阿里与腾讯在to B业务上的竞争更加直接了——阿里云vs腾讯云,钉钉vs企业微信。在刚刚过去的9月,钉钉和企业微信分别与OA市场的龙头公司蓝凌、泛微达成深度的合作,行业内深感AT之间的硝烟弥漫。

不过,比起SaaS领域的擦抢走火,腾讯在国庆前的第三次大变阵更是明确了其在to B领域的决心。

新成立的云与智慧产业事业群(CSIG,即 Cloud and Smart Industries Group)被视为腾讯在B端业务的主阵地,具体产品上,将整合包括腾讯云、智慧零售、安全产品、腾讯地图、优图等核心产品线。

尽管腾讯总是被质疑to B业务能力,没有阿里的销售铁军,C端经验不适合B端,部门墙数据墙很厚,数据丢失事件造成巨大负面影响等等,但它始终还是迈出了这一步,to B已经被列为公开的重点,是腾讯转型产业互联网的重地。

与阿里云相比,腾讯云起步较晚,但依托游戏、视频领域的深耕,腾讯云也快速占据一席之地。

过去未去,未来已来,BAT在B端的布局脉络已非常清晰,无论是谁,单独拿出来看都已自成体系。而格局也是显然的,BAT的提前布局与其在技术、研发、人才、企业端的影响力等方面的优势,已经为他们筑起了一道非常坚固的护城河。在to B时代,BAT扮演着基础服务商、平台运营方的角色,是赋能行业,是基础设施,是企业的第一选择。

还有机会吗?

to B领域巨头换人的可能性几乎为零。

但另一个问题是BAT永远无法避免的——企业用户对数据存储的安全感很低。直白地说,在国外,Netflix敢将自己的基础架构搭载亚马逊云服务AWS上,在国内,爱奇艺敢将自己的性命交给腾讯云吗?

这给了一些中型公司机会。比如UCloud反复强调的就是“中国领先的中立云计算服务商”,其中“中立”二字格外显眼。

而在BAT之外,很多看似完全to C的互联网公司都在B端有所布局。

比如字节跳动(今日头条,后文简称头条)。企业服务竟然是其头条投资第二多的领域(第一领域为文化娱乐)。人们熟知的一些明星项目,例如坚果云、石墨文档、Tower等,头条都有所投资。

京东在企业服务领域一共有超过20笔投资,包括甄云信息、EasyStack、通天晓软件、凌雄租赁、加推科技等等,最近京东云还发布了“医疗健康战略”,想要做医疗行业的基础设施,推动医疗信息化。

不可否认,未来B市场的格局更有可能是BAT继续占领大部分市场,提供基础设施服务,而其他公司则可以选择垂直领域提供更多个性化的服务。毕竟在全球市场上,除了微软、甲骨文等to B巨头,也有很多优秀的“小”公司,比如Slack、Tanium、Sprinklr、AppNexus等等。

至于中国过去的老牌IT公司,或许这一轮to B浪潮会给他们带来新机遇。

一个典型的例子是联想,PC业务之外,联想的数据中心业务正在高速增长。而这一业务增长的关键驱动因素之一便是HyperScale超大规模数据中心业务,简单说,就是联想给做云服务的公司提供设备,这些公司包括美国的云服务公司微软、Google、亚马逊等、也包括中国的云服务公司BAT等等。

华为虽然在去年3月才宣布成立Cloud BU,6月“华为云”品牌才首次亮相,但一年时间,华为云的成绩也非常不错。

而像用友、金蝶等ERP厂商,在过去一段时间里疲态尽显,若是能借此时机重整旗鼓,或着与强者结成联盟,也是不错的选择。

毕竟,To B的金矿就在那里,中国工商登记的企业数量近3000万家,其中中小企业占比90%以上,整体数量超过美国,且仍在持续增加,企业级市场红利非常丰厚。

BAT按照惯例会继续缠斗但又一起分走大部分,而剩下的就要各凭本事了。


          Comment on Opinion: The old City Council majority did not embrace raising the minimum wage; they fought it by hyper_lexic      Cache   Translate Page      
Interesting. I don’t have any issue with her having been a partner and a corporate lawyer - you don’t get there by being stupid - but I do wonder why she obscures this.
          Comment on Opinion: Harness local power to help Berkeley’s housing crisis by Whoa Mule      Cache   Translate Page      
Hyper, There is confusion in this editorial because she does not distinguish between low income housing and housing that is affordable to the working class. The 137 units the editorial refers to are LIHTC sponsored projects, most of which qualify some tenants down to very very low, w/ mental health, aids. So the question is, "What needs to be moved up?" low income housing or above market income housing? They are constructed from completely different financial structures.
          Comment on Opinion: In District 8 race, Candidate Mary Kay Lacey distorts City Councilwoman Lori Droste’s position by hyper_lexic      Cache   Translate Page      
Hmm my reply seems to have disappeared. Suffice to say that I think we’ve discussed this enough and nothing you’ve said has dissuaded me from my perspective that Lacey is at least using language opposed to any new market rate development; and she has (intentionally or unintentionally, I can’t tell) misled voters on the 827 issue.
          Comment on Opinion: In District 8 race, Candidate Mary Kay Lacey distorts City Councilwoman Lori Droste’s position by hyper_lexic      Cache   Translate Page      
I don’t know how “concerned voter” would know whether Hauser’s quote of a conversation with Lacey is accurate, unless “concerned voter” is in fact close to the Lacey campaign and was there for the conversation. Either way - if “concerned voter” wants to question Hauser’s accuracy, he/she should go on record under their real name just like Hauser did.
          嗜酸性粒细胞增多综合征fip1l1pdgfra融合基因的表达及靶向治疗      Cache   Translate Page      
作者单位:215006 江苏省苏州市,苏州大学附属第一医院血液科(韩晶晶、仇惠英、薛永权、吴德沛);江苏省血液研究所(潘金兰、姚利、岑建农)

【摘要】  目的 研究fip1l1pdgfra融合基因在嗜酸性粒细胞增多综合征(hes)中的表达,评价伊马替尼对hes的靶向治疗作用。方法 用荧光原位杂交(fish)及逆转录巢式聚合酶链反应(rtpcr)法检测hes病例f/p融合基因,对阳性标本进行核苷酸序列分析。观察4例伊马替尼治疗患者的临床指标。结果 fish检测15例标本,1例(8.3%)检测到f/p融合基因。rtpcr检测24例标本,4例(16.7%)阳性,其中1例用fish亦检测到f/p融合基因。2例f/p阳性患者,在伊马替尼治疗后短期内均达血液学完全缓解,其中1例达分子生物学缓解。2例f/p阴性者,1例在治疗1月后达血液学完全缓解,另1例于治疗第1天死于急性左心衰。结论 fip1l1pdgfra融合基因是恶性克隆性hes发病的分子基础,伊马替尼治疗f/p阳性患者的血液学缓解率达100%,对部分f/p阴性患者同样有效。

【关键词】  嗜酸性粒细胞增多综合征;fip1l1pdgfra融合基因;伊马替尼

 嗜酸性粒细胞增多综合征(hypereosinophilic syndrome,hes)是一种少见的异质性嗜酸性粒细胞增多性疾病,表现为不明原因的持续性嗜酸性粒细胞增多,伴多脏器功能损害。cools等[1]在hes患者中首次发现fip1l1pdgfra(简称f/p)融合基因,并将f/p阳性患者归类为慢性嗜酸性粒细胞性白血病(chronic eosinophilic leukemia,cel)。而在2008年修订的who标准中,已将f/p阳性患者归类为有pdgfra基因异常的伴嗜酸性粒细胞增多的髓系肿瘤[2]。近年来发现口服伊马替尼(商品名:格列卫)可以使大多数f/p阳性患者得到血液学及分子学缓解[3,4]。我们对我院就诊的hes患者通过分子生物学方法进行了f/p融合基因的检测,对部分患者采用了伊马替尼治疗,现报告如下。

  1 资料与方法

  1.1 一般资料

  选择2005年11月至2008年3月我院门诊诊治的49例hes患者,男30例,女19例;年龄16~80岁,平均年龄45岁;病程12 d~6年,平均14.5个月。hes诊断标准采用chusid诊断标准[5]:(1)外周血中嗜酸性粒细胞绝对计数>1.5×109/l且持续6个月以上或因嗜酸性粒细胞增高于6个月内死亡;(2)排除其他引起嗜酸性粒细胞增高的原因,如寄生虫感染及过敏性疾病;(3)患者必须有器官受累的症状和体征。

  1.2 fip1l1pdgfra融合基因的检测

  对部分患者骨髓标本进行了fip1l1pdgfra融合基因的检测,其中15例(男8例,女7例)患者选用荧光原位杂交(fluorescence in situ hybridization,fish)法,24例(男15例,女9例)选用逆转录巢式聚合酶链反应(rt nested pcr)法,10例(男7例,女3例)同时采用fish和rtpcr法。

  1.2.1 fish检测方法:采用r显带技术处理染色体标本,标本经处理后,通过与探针杂交变性洗涤,复染,用leica q550cw荧光显微镜在dapi/fitc/texas red三色滤光镜激发下观察间期细胞荧光杂交信号:3色荧光信号者(依次为绿、橙、蓝)为f/p融合基因阴性,双色信号者(依次为绿、蓝,橙色信号缺失)为f/p阳性,至少分析300个间期细胞。

  1.2.2 rtpcr检测方法:标本均来自骨髓。检测方法参考文献[6]。

  1.3 伊马替尼治疗部分hes患者

  2例f/p阳性患者选择伊马替尼治疗;2例f/p阴性患者,激素治疗效果不明显情况下改用伊马替尼治疗。初始剂量200~400 mg/d,达到临床或分子生物学缓解后逐渐减量,缓解期以小剂量维持治疗(100 mg/3 d~200 mg/d)。

  2 结果

  2.1 fish检测fip1l1pdgfra融合基因结果

  15例患者的骨髓标本核型分析均为正常核型。12例有杂交信号,其中1例(8.3%)检测到间期分裂相染色体4q12长臂上碱基对的缺失,即f/p融合基因阳性,见图1。图1 fip1l1pdgfra融合基因阳性fish结果

  2.2 rtpcr检测fip1l1pdgfra融合基因结果

  2.2.1 琼脂糖凝胶电泳检测结果:24例中4例(16.7%)可见特异性条带,即f/p融合基因阳性,男3例,女1例,见图2。图2 fip1l1pdgfra融合基因琼脂糖凝胶电泳检测结果m:marker;1~2:fip1l1pdgfra阳性;3~4:fip1l1pdgfra阴性;5:空白对照2.2.2 阳性标本测序结果:2例f/p阳性患者进行了核苷酸测序,结果显示fip1l1基因5'端的断裂点分别位于8号、12号内含子;而pdgfra基因3'端的断裂点均在12号外显子附近,见图3。红色箭头所示为断裂点位置图3 2例fip1l1pdgfra阳性患者测序结果2.3 fip1l1pdgfra融合 本组4例fip1l1pdgfra融合基因阳性患者,3例(75%)脾肿大,其中1例同时伴肝肿大;3例(75%)淋巴结肿大;1例(25%)骨髓纤维化。而f/p阴性患者上述特征则不明显。此外,4例f/p阳性患者的外周血嗜酸性粒细胞比例明显增高,平均78.2%;嗜酸性粒细胞绝对计数平均15.2×109/l。其他表现如贫血2例(50%)及血小板减少2例(50%)在f/p阳性的患者中也较常见。因阳性病例较少,未作统计学比较。

  2.4 伊马替尼治疗

  本组4例患者均为男性,染色体均为正常核型;2例f/p融合基因阳性,另2例p/f阴性。病例1、2、3在伊马替尼治疗前曾口服强的松治疗,未见明显疗效,见表1。表1 伊马替尼治疗4例hes患者临床特征及疗效观察

  3 讨论

  大量研究报道称fip1l1pdgfra融合基因突变率约为10%~15%[4]。我们的研究结果显示,f/p融合基因在本组病例中发生率为13.8%(4/29),与文献报道相符。本组研究中,fish法阳性率为8.3%,rtrcr法阳性率为16.7%。rtpcr方法的灵敏度确实要优于fish,但fish通过直接检测染色体的缺失来检测融合基因,其特异性较强,很少会出现假阴性的结果。

  根据2008年修订的who造血和淋巴系统肿瘤诊断标准,将hes/cel修订诊断为“有fip1l1pdgfra,fip1l1pdgfrb或fgfr1基因异常的伴嗜酸性粒细胞增多的髓系和淋巴系肿瘤”以及cel,nos[2]。本组4例f/p融合基因阳性患者,可诊断为有pdgfra基因异常的伴嗜酸性粒细胞增多的髓系肿瘤。其余融合基因阴性患者,没有细胞遗传学异常,并且幼稚细胞的比例<20%,诊断为特发性嗜酸细胞增多综合征(ihes)。

  klion等[7]的研究表明,f/p融合基因阳性患者中,骨髓增生特征(脾大,骨髓纤维化等),嗜酸性粒细胞绝对计数增高,血清类胰蛋白酶和vitb12升高更为多见。本组4例f/p阳性患者中,均有不同程度的肝脾、淋巴结肿大,外周血嗜酸性粒细胞绝对计数及嗜酸性粒细胞分类比例明显升高,而f/p阴性患者上述特征则不明显。

  2001年,schaller等[8]报道了首例伊马替尼治疗hes患者,每天服用100 mg,4 d后获得血液学完全缓解,35 d后外周血嗜酸性粒细胞恢复正常。本组2例用伊马替尼治疗的f/p阳性患者,均在短期内(分别为3 d、2周)达到了血液学完全缓解,其中1例在治疗3个月后融合基因转为阴性,提示已经达到分子学缓解。1例f/p阴性患者在用伊马替尼200mg治疗1 d后死于急性左心衰,其死亡原因可能与本病浸润有关,早期加用糖皮质激素可能会降低病死率。有关伊马替尼长期治疗的疗效及相关不良反应尚待进一步研究。

【参考文献】
   1 cools j,de angelo dj,gotlib j,et al.a tyrosine kinase created by fusion of the pdgfra and fipil1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndro me.n engl j med,2003,348:12011214.

  2 tefferi a,vardiman jw.classification and diagnosis of myeloproliferative neoplasms:the 2008 world health organization criteria and pointofcare diagnostic algorithms.leukemia,2008,22:1422.

  3 pardanani a,brockman sr,paternoster sf,et al.fip1l1pdgfra fusion:prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosi nophilia.blood,2004,104:30383045.

  4 jovanovic jv,score j,waghorn k,et al.lowdose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in fip1l1pdgfra positive chronic eosinophilic leukemia.blood,2007,109:46354640.

  5 chusid mj,dale dc,west bc,et al.the hypereosinophilic syndrome:analysis of fourteen cases with review of the literature.medicine (balti more),1975,54:127.

  6 张悦,于明华,肖志坚,等.慢性嗜酸粒细胞白血病/高嗜酸粒细胞综合征临床和实验室特征研究.中华血液学杂志,2008,29:38.

  7 klion ad,noel p,akin c,et al.elevated serum tryptase levels identify a subset of patients with ……

          Hyperion Planning/Essbase Sr. Consultant - Perficient - National, WV      Cache   Translate Page      
2+ years with ERP accounting systems such as Oracle, SAP, Peoplesoft, Great Plains, etc. At Perficient you’ll deliver mission-critical technology and business...
From Perficient - Tue, 04 Sep 2018 20:47:57 GMT - View all National, WV jobs
          University Services Program Associate - University of Wisconsin - Stout - Menomonie, WI      Cache   Translate Page      
Experience with PeopleSoft, WISDM, Hyperion, AccessStout, and other related software to query and provide data for program directors....
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          University Services Program Associate - UW Stout - Menomonie, WI      Cache   Translate Page      
PREFERRED 3 years or more of demonstrated office experience Experience with PeopleSoft, WISDM, Hyperion, AccessStout, and other related software to query and...
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          NCCC Cinemas Buhangin Opens October 10!      Cache   Translate Page      

Enjoy high-quality video projection and hyper-realistic audio through its Dolby Atmos surround sound, only at NCCC Cinemas Buhangin!

The post NCCC Cinemas Buhangin Opens October 10! appeared first on DavaoBase.


          Senior Systems Administrator - Information Technology - Veracity Forecasting and Analysis - Alexandria, VA      Cache   Translate Page      
VM Ware 5.5/HyperV/Virtual Machines. Resolve hardware problems that may require replacing internal server parts (e.g., memory boards, hard drives, etc.)....
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          Hyperespace von Anthony Doriand      Cache   Translate Page      
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          Planet Coaster: World's Fair Pack (DLC) angekündigt      Cache   Translate Page      
Frontier Developments hat das World's Fair Pack für Planet Coaster angekündigt. Die Erweiterung wird am 16. Oktober 2018 für 10,99 Euro erscheinen. Der DLC umfasst zehn internationale Szenerien, zwei neue Coaster, 300 Bauelemente und mehr als 60 Landschaftselemente.
 
Das World's Fair Pack beinhaltet:
  • "Zehn neue, internationale Szenerien die von China, den USA, Frankreich, Marokko, Italien, Deutschland, Japan, Großbritannien, Mexiko und Spanien inspiriert wurden
  • Die neue Transport-Bahn: Polarity - eine fahrerlose magnetgetriebene Bahn
  • Den Jixxer und Intercepter: Ein duellierendes Duo, welches sich mit Motorrad-Wägen eine hyper-dynamische Verfolgungsjagd liefert - angefeuert durch einen Hochgeschwindigkeits-Hydraulik-Antrieb, starten die Motorräder auf einer Bahn mit zwei separaten Spuren ihr Rennen
  • Über 300 maßgeschneiderte Bauelemente mit kulturellen Requisiten, Beschilderungen, Zäunen und Pfaden decken die Erscheinungsbilder der zehn Länder ab"
 
Zusätzlich zum World's Fair Pack gibt es ein kostenloses Update auf Version 1.8 für alle Spieler. Es beinhaltet neue Restaurants, Verkaufsautomaten und einige Verbesserungen (zum Change-Log).

Weiter zum Video

          Carrefour : la Champenoise Marie Cheval à la tête des hypermarchés français.      Cache   Translate Page      
Elle vient d’être nommée directrice exécutive « commerce, services et transformation digitale...

Entreprises à la Une
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          Carrefour : Christophe Lalene, directeur de Champagne-Nord.      Cache   Translate Page      
Il chapeaute 13 hypermarchés, notamment dans l’Aisne, la Marne et les Ardennes.

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          پی آر پی در ارتوپدی      Cache   Translate Page      





پلاسمای غنی از پلاکت  (PRP)

در طی چند سال گذشته، مطالب زیادی درباره روشی به نام پلاسمای غنی از پلاکت (PRP) و اثربخشی بالقوه آن در درمان آسیب ها نوشته شده است.

بسیاری از ورزشکاران معروف ( تیرر وودز، ستاره تنیس رافائل نادال و چندین نفر دیگر ) برای مشکلات مختلفی مانند پیچ خوردن زانوها و آسیب های مزمن تاندون پی آر پی را انجام داده اند. این نوع مشکلات به طور معمول با دارو درمانی، فیزیوتراپی یا حتی جراحی درمان می شوند. برخی از ورزشکاران با پی آر پی به سرعت به رقابت ها بازگشت داشته اند و این باعث اعتبار بخشیدن به پی آر پی شده است.

با وجودی که بر روی پی آر پی تبلیغات گسترده ای صورت گرفته است، هنوز هم در مورد آن سؤال های باقی مانده ای جود دارد، از قبیل:

    
پلاسما غنی از پلاکت ( پی آر پی ) دقیقا چیست؟
    
پی آر پی چگونه کار می کند؟
    
چه مشکلاتی با پی آر پی درمان می شود؟
    
آیا درمان پی آر پی موثر است؟

پلاسمای غنی از پلاکت (PRP) چیست؟

گرچه خون عمدتا از مایعی (به نام پلاسما) تشکیل شده است، ولی علاوه بر آن حاوی اجزای جامد کوچکی ( سلول های قرمز، سلول های سفید و پلاکت ها ) هم می باشد. پلاکت ها را بیشتر به دلیل اهمیت شان در لخته شدن خون می شناسیم. با این حال، پلاکتها حاوی صدها پروتئین به نام فاکتورهای (عوامل) رشد هم هستند که در بهبود زخم ها بسیار مهم می باشند.

پی آر پی، پلاسمایی است که دارای پلاکت های بیشتری نسبت به آنچه معمولا در خون وجود دارد، می باشد. غلظت پلاکتها ( و در نتیجه غلظت عوامل رشد ) در پی آر پی می تواند 5 تا 10 برابر بیشتر (یا غنی تر) از حد معمول باشد.

برای آماده سازی  پی آر پی، ابتدا باید از بیمار خون گرفته شود. پلاکت ها طی فرایندی به نام سانتریفوژ از دیگر سلول های خونی جدا گشته و مجددا طی همان فرایند غلظت آنها افزایش می یابد.

پی آر پی چگونه کار می کند؟

اگرچه دقیقا مشخص نیست که پی آر پی چگونه عمل می کند، مطالعات آزمایشگاهی نشان داده است که افزایش غلظت فاکتورهای رشد در پی آر پی به طور بالقوه می تواند روند بهبود را افزایش دهد.

برای سرعت بخشیدن به روند بهبود، محل آسیب با پی آر پی آماده شده تحت درمان قرار می گیرد. این کار را می توان به یکی از  دو روش زیر انجام داد:

   

·          پی آر پی را می توان دقیقا به منطقه آسیب دیده تزریق نمود. به عنوان مثال، در تاندونیت آشیل ( یک بیماری که معمولا در دوندگان و تنیسورها دیده می شود)، تاندون بالای پاشنه می تواند متورم، ملتهب و دردناک شود. مخلوطی از پی آر پی و محلول بیحسی موضعی می تواند به طور مستقیم به این بافت ملتحب تزریق شود. پس از آن، در یک یا دو هفته اول درد در ناحیه تزریق ممکن است افزایش یابد و ممکن است چند هفته طول بکشد تا بیمار احساس بهبودی نماید.

·             پی آر پی همچنین ممکن است در برخی از صدمات برای بهبود زخم پس از جراحی استفاده شود. برای مثال، ورزشکاری با تاندون پاشنه کاملا پاره شده ممکن است برای ترمیم تاندون تحت عمل جراحی قرار گیرد. تزریق پی آر پی به منطقه آسیب در طی جراحی می تواند سرعت و کیفیت ترمیم تاندون پاره شده را افزایش دهد.

چه مشکلاتی با پی آر پی درمان می شود؟ آیا این روش موثر است؟


در حال حاضر تحقیقات زیادی برای ارزیابی اثربخشی درمان پی آر پی در حال انجام است. عوامل موثر بر اثربخشی درمان پی آر پی عبارتند از:

    
منطقه ای از بدن که تحت درمان است
    
سلامت کلی بیمار
    
آیا آسیب حاد است (مثل سقوط) یا مزمن (آسیب به مرور زمان)

آسیب های مزمن تاندون

با توجه به مطالعات انجام شده ای که تا به حال گزارش گردیده، پی آر پی بیشترین تاثیر را در درمان آسیب های مزمن تاندونی، به ویژه آرنج تنیس بازان ( آسیبی شایع تاندون ها در قسمت خارجی آرنج ) دارد.

استفاده از پی آر پی برای سایر آسیب های تاندونی مزمن، مانند تاندونیت مزین آشیل مزمن یا التهاب تاندون پاتلا در زانو (زانوی ورزشکاران رشته پرش) امیدوار کننده است.


عوارض حاد و عضلانی

بخش عمده ای از مطالبی که درمورد درمان پی آر پی گفته می شود مربوط درمان آسیب های ورزشی حاد، مانند آسیب های رباط ها و آسیب های عضلانی بوده است. پی آر پی برای درمان ورزشکاران حرفه ای با آسیب های ورزشی معمول مانند کشیده شدن عضلات همسترینگ ران و کشیدگی های زانو مورد استفاده قرار گرفنه است.


عمل جراحی

اخیرا، پی آر پی  در طی انواع خاصی از جراحی ها برای کمک به ترمیم سریعتر و بهتر بافتها مورد استفاده قرار گرفته است. برای اولین بار این روش در جراحی های شانه برای درمان پارگی تاندون های روتاتور کاف مورد استفاده قرار گرفت.

جراحی برای ترمیم پارگی رباط های زانو، به خصوص رباط صلیبی قدامی (ACL) منطقه دیگری است که برای آن از پی آر پی استفاده شده است.


آرتروز زانو

برخی از تحقیقات اولیه برای ارزیابی اثربخشی پی آر پی  در درمان آرتروز زانو انجام گشته و بخصوص نتایج آن در مقایسه با روش های قدیمی تر بسیار موفقت آمیز گزارش شده است.

 

شکستگی ها

پی آرپی به طور محدود برای سرعت بخشیدن به روند بهبودی استخوان های شکسته نیز استفاده شده است.


نتیجه

استفاده از درمان با روش پی آر پی در بسیاری از مشکلات ارتوپدی در حال فراگیر شدن است. با این حال به نظر می رسد این روش در درمان آسیب های مزمن تاندونی و در درمان آرتروز مفاصل موثرتر باشد.
با وجودی تفاوت در میزان تاثیر پی آر پی در مشکلات مختلف ارتوپدی، خطرات ناشی از آن حداقل هستند:

ممکن است درد در محل تزریق موقتا افزایش یابد، اما به نظر نمی رسد بروز سایر مشکلات (عفونت، آسیب بافتی، آسیب های عصبی ) در مقایسه با تزریق کورتیزون تفاوتی داشته باشد.


          Jele Jelz - No News (Prod. By Chef Pasquale) [Music Video] | GRM Daily      Cache   Translate Page      

SUBSCRIBE: http://bit.ly/GRMsubscribe VISIT: http://grmdaily.com/ ✅ DOWNLOAD THE GRM DAILY APP FOR iOS & ANDROID NOW! hyperurl.co/f3gkct ...

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Posted: 09 Oktober 2018


          High blood pressure - eat more of this 20p vegetable to slash hypertension risk      Cache   Translate Page      
HIGH blood pressure could be caused by eating an unhealthy diet, or not getting enough exercise. You could lower your risk of hypertension symptoms by eating more of this cheap vegetable. (Source: Daily Express - Health)
          High blood pressure - the one exercise you should always avoid with hypertension      Cache   Translate Page      
HIGH blood pressure risk could be lowered by making some diet or exercise swaps. You could prevent hypertension symptoms by keeping active and staying fit. But, you should avoid doing this exercise or risk high blood pressure signs. (Source: Daily Express - Health)
          Ve spirále hyperinflace. Venezuelská ekonomika míří dolů rychlým tempem      Cache   Translate Page      
Nejnovější prognózy Mezinárodního měnového fondu posouvají odhadovanou hranici venezuelské inflace stále výše. Na konci roku má dosáhnout 1,37 milionu procent. V příštím roce by číslo mohlo vylétnout až k 10 milionům procent. Obyvatelé kdysi nejbohatšího jihoamerického státu se v současnosti potýkají s hlubokou bídou.
          Vitamin D supplementation: of scandal, sunlight, and skin in the game      Cache   Translate Page      
The New York Times recently ran a story indicating that a prominent physician scientist particularly associated with advocacy for vitamin D supplementation may have important conflicts of interest. The case is made that this doctor, an endocrinologist at Boston University, has personally contributed enormously to sales of vitamin D, testing for vitamin D, and even the use of tanning salons through his influence on peers and the public. He has in turn been at the receiving end of very considerable compensation from companies that make and sell supplements, perform tests, or offer tanning beds.

That any single individual, whatever their professional pedigree, should exert a major influence on widespread medical testing and practice is unusual. The story in this case contends, however, that prominence (the physician in question has published hundreds of peer-reviewed papers and has had a role in drafting official vitamin D guidelines) and proselytism have mingled with particular potency.

Be that as it may, I favor vitamin D supplementation (in general) despite no familiarity with the advocacy of this particular doctor, and despite relying on more cautious, and reliably unbiased sources. For me, this is a story about both scandal and sunlight, with a sidebar about the nature of scientific evidence and how we interpret it.

Let's start with scandal. Yes, at this point, the protagonist in the New York Time's plot has reportedly made quite a bit of money from his vitamin D advocacy. That could mean he is biased, even deceitful, and driven by ulterior motives. But it doesn't necessarily mean any of that.

I recall the time when Al Gore was accused by political opponents of having conflicts of interest because he had investments in “green energy” companies. Gore convincingly responded with the obvious rebuttal: these critics were misconstruing cart for horse. In other words, Gore advocated for responses to climate change not to make money, but from deep conviction. He subsequently did just what we are all told people with real integrity do: put his money where his mouth was. He invested in companies that were doing the very things he was calling on industry to do. He was advancing the mission to which his devotion was already a matter of public record.

One of our problems in this age of rampant scandal is that we rush to judgment. Partisanship, propaganda, Internet echo chambers, and click-bait hyperbole all foster this. The days of reserved judgment are quaintly archaic now. But this is to the detriment of us all, because we are prone to be wrong in every extreme direction, never settling on more moderate truths.

I found peer-reviewed publications on vitamin D by the impugned physician going back 48 years. His industry funding goes back not nearly so far. So, there is an alternative, plausible narrative: a researcher devoted to the study of vitamin D became convinced of widespread deficiency and the importance of redressing it. As he became prominent over the years, so did his advocacy, based on his own research and that of others. As his advocacy became prominent, it caught the attention of industry elements. Eventually, they came along to say: your message benefits our bottom line, so we would like to support it, and you. We can help amplify your message with money; you don't need to change what you were already saying. And then … here we are.

This narrative does not entirely eliminate concerns about conflict. Someone with significant funding from specific industry elements should not be involved in drafting impartial, national guidelines with direct implications for those patrons. But before over-interpreting the implications of scandal, we should all pause to consider that this doctor's advocacy may be honest, based on his view of the evidence, and just what it was before any money was involved. As for Al Gore, conviction and advocacy may have, and seemingly did, come first; an exchange of dollars only late in the game.

My position about scandal, then, is that we have more than our share of the real thing to deal with these days. The possibility of ulterior motives does not prove them, and even ulterior motives don't necessarily disprove the conclusions. They are reasons for concern, and scrutiny, and we may credit the New York Times' coverage for inviting that. But any given position is not safely correct simply because motives are pure, nor reliably incorrect just because motives are dubious. The “what” may be right, or wrong, independent of the “why.”

Which leads to sunlight, where contaminated conclusions about vitamin D may most reliably be disinfected. As noted, I favor vitamin D supplementation with no vested interest other than public health. I serve as a science advisor to certain nutrient supplement manufacturers, but have no activity or interests related directly to vitamin D.

My position derives from adaptation, and the proposition that we all very literally have skin in this game.

Vitamin D is not really a nutrient; it is a hormone. Under the native conditions to which our species is adapted, we don't need vitamin D from food. Rather, we make it from sunlight. Dark skin, the original condition of our common ancestors, protects against intense, equatorial sun, while allowing for adequate vitamin D production to foster healthy growth and development.

When our ancestors migrated out of Africa, away from the equator, and into fewer hours of less intense sunlight, dark skin no longer reliably made enough vitamin D. A mutation favoring skin pallor was advantageous under those conditions, and we see the effects to this day. The most famously light-skinned peoples, Irish and Scandinavians, come from either far northern climes, or from under frequent cloud cover, if not both.

Vitamin D, quite simply, is why any of us is white. That says something about the profound reverberations of this compound through our physiology, where it controls calcium absorption and skeletal development, but also influences energy metabolism, immune function, and much more.

Paleoanthropologists estimate that our native levels of vitamin D were higher than we tend to see in modern populations, based on what we know about levels achieved by populations living outdoors with frequent sun exposure. If we use adaptation as our default, supplementation is warranted simply to approximate the levels native to our kind.

So, I favor judicious supplementation. I live in New England, work indoors, and get limited sun exposure much of the year. Accordingly, I take 2000 IU of vitamin D3 daily in winter; 1,000 IU daily in summer; and skip it altogether during outdoor vacation time. I think dosing can and should be personalized to correspond with patterns of diet, lifestyle, and sun exposure. I advise against tanning beds, as I think the harms outweigh any potential vitamin D-related benefits.

As for testing, I generally need a reason. Reasons include any symptoms or signs of vitamin D deficiency, such as unexplained bone thinning; a specific patient request; a condition causing intestinal malabsorption; or kidney disease, which can interfere with activation of the vitamin D molecule (vitamin D is activated through sequential hydroxylation steps in the liver and kidney; don't ask! Active vitamin D3 refers to the compound produced by these steps). But frankly, I think vitamin D testing is of far greater value than many of the measures in so-called “routine blood work,” which is in fact ordered as a matter of fairly futile routine. I think it is at least as reasonable to test vitamin D routinely as it is to test blood counts and blood chemistries, and perhaps a bit more so.

Finally, there is the matter of evidence. The New York Times reported the lack of clear benefit from vitamin D in randomized trials as damning. But absence of evidence is not evidence of absence. In other words, failing to show the decisive health benefits of a nutrient, or spinach, or blueberries, does not preclude such benefits. If we did for exercise what we do for diet, we would need to prove not that walking is good for health, but that any one particular step on a very long walk exerted an independent effect on health.

Consider that people who are robustly healthy, exercise routinely, get outdoors often, and eat an optimal and varied diet are least likely to have vitamin D deficiency, or to show any obvious response to vitamin D supplementation for the most obvious of reasons: you can't fix what isn't broken. At the other end of the scale, people prone to vitamin D deficiency in conjunction with ill health, poor diet, and lack of outdoor activity – are unlikely to get much better just from vitamin D. The isolated effect of any one piece of the whole lifestyle formula is very hard to demonstrate in a clinical trial because it tends to be very small, no matter what that piece is. When effects are real and relevant, but relatively small, uncommon, or both - truly massive (hundreds of thousands of participants) or massively long (decades) trials are needed to reveal them. Smaller, shorter trials tend to show no particular effect, and neither prove nor disprove the absence of one.

Finally, nutrient supplementation in a generally healthy population may tend to take body levels of the substance from adequate to optimal, and do much the same for health. Randomized trials far less dependably discern a change in “overall vitality” than they do the presence or absence of some particular condition.

We all have reason to care about vitamin D, no further away than the surface of our own skin. It may well be that popular narrative and professional discourse on the topic are now home to the contaminants of bias and conflict. Confusion tends to dissipate, and reasonable conclusions reveal themselves, however, if we avoid a rush to judgment, and examine the whole story under the bright light of day.

David L. Katz, MD, FACP, MPH, FACPM, is an internationally renowned authority on nutrition, weight management, and the prevention of chronic disease, and an internationally recognized leader in integrative medicine and patient-centered care. He is a board certified specialist in both Internal Medicine, and Preventive Medicine/Public Health, and Associate Professor (adjunct) in Public Health Practice at the Yale University School of Medicine. He is the Director and founder (1998) of Yale University's Prevention Research Center; Director and founder of the Integrative Medicine Center at Griffin Hospital (2000) in Derby, Conn.; founder and president of the non-profit Turn the Tide Foundation; and formerly the Director of Medical Studies in Public Health at the Yale School of Medicine for eight years. This post originally appeared on his Linked In page.
          Melania's trip to Africa says a lot about US foreign policy under Trump - Vox      Cache   Translate Page      

Vox

Melania's trip to Africa says a lot about US foreign policy under Trump
Vox
First lady Melania Trump has wrapped up her first solo trip to Africa, where she made stops in Ghana, Malawi, Kenya, and Egypt — a subtle rejection of her husband's nationalist and xenophobic worldview. The point of Trump's tour was to highlight all ...
Melania Trump wants our respect. Here's how she could earn it.Washington Post
Analyzing what Melania Trump wore during her four-nation African tour: it's complicatedAOL
Melania Trump Gave Us All a Valuable Lesson in How Not to Dress in AfricaTownandCountrymag.com
Hyperallergic -BET -Chron.com -The National
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          Software Support Technician - Hypertec - Montréal, QC      Cache   Translate Page      
Since its inception nearly 30 years ago, Hypertec Group's continuous dedication to innovation, research and development together with its long-term...
From Indeed - Tue, 09 Oct 2018 15:14:12 GMT - View all Montréal, QC jobs
          Comment on CONTACT by new homes      Cache   Translate Page      
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          Concession Champs | Adrenalin      Cache   Translate Page      
BC Place, Bell MTS Place and the Scotiabank Centre Halifax are all included, with the key points here focusing on food that is hyper-local, healthy and Instagrammable. “A large segment of the sports audience is coming not just to see the game, but to enjoy the food,” says Paul Pettas, communications director for Connecticut-based Centerplate, […]
          Dane Saville posted a blog post      Cache   Translate Page      
Dane Saville posted a blog post

How to Build an Effective Buyer Persona for Car Shoppers

According to a CBS News study, today’s consumer sees 5,000 ads per day. That breaks down to 3.5 every single minute. On average, people spend 41 minutes on social media each day. That means we’re all exposed to an overwhelming number of ads during that time.With all of those ads you’ve viewed on social media, has one compelled you to buy something?If you did, chances are the ad spoke to you. Maybe you discovered that your dog can have the same fresh food you cook for your family:Or maybe you’re passionate about buying from companies who give back (data suggests many millennials are). This Bombas ad would remind you that a pair of socks is donated for every pair purchased.Therein lies the problem for marketers: Not everyone wants to buy homemade dog food, and not everyone feels charitable.So, you’re wondering what this has to do with buying a car.Buyer Personas for Car DealershipsThese same principles apply to the purchase of a vehicle. A 22-year old recent college graduate, without children, will likely laugh at the idea of buying a minivan. While there are exceptions to every rule, the data suggests that most minivans are bought by parents or elderly couples. By not narrowing your focus to this ideal target consumer, you’re wasting ad spend on targets who will never convert to customers.Social media marketing has an advantage over many other channels: the ability to hyper-target an audience. Social media advertisements let you identify and target someone who’s most likely to purchase a luxury car because they fit the description of the ideal target buyer.How? People on social media often have specific interests on their profiles that help marketers identify them.For the luxury buyer, they probably prefer brands like Chanel or Burberry — not TJMaxx and Great Value.Narrowing the focus of your stimulus marketing with robust demographic and psychographic targeting will increase the likelihood that your content reaches the most anxious buyer.That’s why buyer personas are vital. Ask yourself:What makes your target consumer tick?What do they enjoy in their free time?What types of products do they buy?What stores do they frequent?What brands do they advocate?The answers to these questions elevate themes that are important to target your ideal customer.Have More Questions About Social Media?You can get more information and data about the power of social media by subscribing to our monthly educational newsletter. You’ll regularly receive a collection of our month’s best content about social media, search engine optimization, paid search, and more.See More

          5 signes qui prouvent que tu es hypersensible      Cache   Translate Page      

1. Vous êtes introverti.

Vous ne l’êtes pas forcément, mais c’est probablement le cas pour ceux qui ont été un peu bousculés pendant leur enfance ou qui n’ont pas été habitués à rencontrer et échanger avec diverses personnes. Vous êtes particulièrement observateur, à l’écoute et créatif. C’est plutôt positif !

2. Vous dépendez du regard des autres.

Vous cherchez à plaire, vous craignez les conflits et avez du mal avec la critique. Vous cherchez l’accord de l’autre, son soutien, vous avez du mal à assumer vos envies et vos choix.

3. Vous êtes empathique.

Vous ressentez facilement les émotions des autres et êtes très attentionné(e), enfin vous compatissez beaucoup. Vous faites énormément d’efforts et culpabilisez lorsque vous échouez. Mais vous ne pouvez pas porter toute la misère du monde sur vos épaules, essayez de prendre de la distance et de vous consacrer sur vos propres besoins.

4. Vous fondez régulièrement en larmes.

Les jugements négatifs peuvent vous faire pleurer, c’est pourquoi vous évitez les situations conflictuelles. Vos pleurs permettent de vous libérer de cette charge émotionnelle, c’est donc très sain !

5. Vous êtes à fleur de peau.

L’environnement, le stress ou la musique vous touche profondément. Irritations, démangeaisons… votre hypersensibilité est aussi physique, écoutez ce que vous dit votre corps !


          On peut observer l'hyperespace, mais les camps de Daesh, là, c'est plus compliqué...      Cache   Translate Page      


          La marque HEMA sort une gamme capillaire hyper complète      Cache   Translate Page      

Après avoir rempli son cartable de marqueurs make-up à la rentrée dernière, la marque Hema nous surprend à nouveau avec cette innovation : une gamme capillaire nommée "Mermaid Hair don't care".

L’été étant maintenant bien terminé, Hema propose cette ligne de produits qui sauront apaiser les cuirs chevelus, redonner du volume et régénérer en profondeur. Du shampoing, au masque en passant par les sprays, la marque "lifestyle" a concocté un florilège d’accessoires et de produits pour retrouver une crinière de sirène.

Pas moins de 20 nouveautés composent cette collection, toujours à des prix cassés (moins de 10 euros). Hema propose : des sprays capillaires (protecteur de chaleur, à base de sel et aussi volumateur), des brosses (en bois et en plastique), des shampoings et après-shampoings enrichis à la Kératine pour les cheveux secs mais aussi à base de protéine de riz pour les chevelures en manque de volume.

Et ce n'est pas tout, l’enseigne hollandaise a aussi imaginé une gamme de coloration éclatante allant du brun au cuivré en passant par le blond. Mais pour celles qui hésitent encore à sauter le pas, Hema a aussi pensé à vous avec des teintures temporaires. Du rose, du violet, du bleu, pour apporter du pep’s en 10 minutes à votre chevelure. 

Pour finir, ils ont enrichi leur gamme de petits électroménagers avec des sèches-cheveux, brosse lissante et autre fer à boucler.

Filez vite chez Hema, vous en sortirez avec de quoi vous coiffer !


          Why are the Officers and Employees of Civil Liberties Group Liberty Refusing to Implement its Policy of Opposition to the IHRA?      Cache   Translate Page      

According to Liberty’s Olivia Percival, ‘Liberty is not actively campaigning against the IHRA definition’


Liberty, formerly known as the National Council for Civil Liberties, was founded in 1934. This was a time of heightened anti-fascist activity in which the Jews of the East End of London were under attack from Oswald Moseley’s British Union of Fascists.  In 1989 the organisation changed its name to Liberty.

The organisation has provided a career path for budding Labour politicians such as Patricia Hewitt, who went on to become an MP and in charge of Neil Kinnock’s personal office before being brought down by the cash for influence scandal.  Harriet Harman was a former legal officer and her husband Jack Dromey was Chair of the Executive Committee. Shami Chakrabarti the previous Director is now Shadow Attorney General. What all the ex-employees of Liberty who find their way to the top of the Labour Party have in common is their abandoning and jettisoning of any pretence of support for civil liberties.  Harriet Harman for example went along with all Tony Blair’s anti-terrorism legislation without a squeak. Chakrabarti’s attack on Ken Livingstone suggests that she too considers civil liberties to be a drag on her career.
Martha Spurrier, another in a long line of hopeful Establishment Labour politicians
The current Director, Martha Spurrier is, like her predecessor, a barrister. Liberty/NCCL has never been a particular radical organisation, especially in recent times. In its earlier times it had no difficulty supporting for example the internment of Oswald Moseley in the war, something which led to mass resignations from the organisation.
During the period of Hewitt and Harman the organisation adopted a policy which was in effect pro-paedophile. The Paedophile Information Exchange became affiliated at one point and it was only in 1983 that the organisation rejected paedophilia as just another sexual life style. All that can be said about this period is that paedophile groups were able to take advantage of the sexual revolution of the 1960’s to propagate the idea that sexual freedom should include the right of adults to have sex with children and that this found favour amongst a section of the libertarian left and gay rights campaigners such as Peter Tatchell.
Liberty/NCCL has always seen itself as part of the British Establishment. It is therefore no surprise that when Professor Jonathan Rosenhead of the LSE moved a motion at the May 2018 AGM, seconded by Louise Christian, a well known solicitor, opposing the International Holocaust Remembrance Alliance definition of anti-Semitism, its officers took fright. The motion itself was passed almost unanimously.
The IHRA is a consensus position of the British political establishment and Liberty is, if nothing else, an establishment group. When I heard that the motion had been passed I wrote to Liberty inquiring about their new policy.  I heard nothing for some months.
I had quite forgotten about my inquiry until an email arrived from Olivia Percival, a former government solicitor who is now Liberty’s Advice & Information Officer. As I read the email I became more and more disconcerted. Ms Percival did not have one good thing to say about Liberty’s policy. What she seemed to be doing was to explain why the organisation was doing nothing about the organisation. 
Percival first began by telling me that ‘I would emphasise that the motion reaffirmed Liberty’s opposition to anti-semitism in all its forms’. The implication being that opposition to the IHRA might be construed as support for anti-Semitism!
It was the next paragraph that left me open mouthed. It would appear that Percival, who is clearly not stupid, deliberately didn’t want to understand the reason for opposition to the IHRA: She wrote that:
‘As an organisation that both fervently supports free speech and fervently opposes anti-semitism, Liberty has an obligation to carefully consider the intersection of these two issues. Whenever we talk about hate speech, we immediately have to think about the boundaries of free speech. Drawing that boundary is not always easy. The position Liberty has taken on the IHRA definition comes from a good faith effort to think through this issue.
The clear implication being that opposition to the IHRA meant support for anti-Semitic hate speech. Why else would she talk about the ‘intersection’ of the two issues of free speech and anti-Semitism?
What Percival was doing was to revisit the policy of Liberty’s American equivalent, the American Civil Liberties Union which infamously supported a march through the Skokie in Chicago, where large numbers of Holocaust survivors lived, by the American Nazi Party. See the NYT, July 1978 THE A.C.L.U. AGAINST ITSELF.
Olivia Percival's email to Tony Greenstein
Thousands of Jews and others left the ACLU over their support for the right of neo-Nazis to propagate their filth and hatred. Indeed this controversy briefly surfaced in the NCCL  when its American Director, Andrew Puddephat I believe, argued for the freedom of speech of fascists in this country. It sparked a heated controversy within the NCCL which led to his departure.
Percival however has completely misunderstood the nature of the opposition to the IHRA, some would say deliberately so. Jonathan Rosenhead is himself Jewish. Neither he nor Jewish Voice for Labour of which he is a member support free speech for anti-Semites. Opposition to the IHRA has nothing to do with support for free speech for racists and fascists. There may indeed be an interesting discussion about ‘the boundaries of free speech’ when it comes to hate speech but it has nothing to do with the IHRA and it is dishonest for Percival to suggest otherwise.
Opposition to the IHRA is about opposition to the attack on the rights of supporters of the Palestinians and anti-Zionists to oppose Israeli Apartheid. It has nothing to do with supporting the rights of anti-Semites. It is disingenuous to suggest this.
The American ACLU defended the rights of Nazis in Skokie, Chicag- pictured is a Vietnam veteran
If Olivia Percival had bothered to read the resolution which was passed she would know that it begins by reiterating its ‘abhorrence of antisemitism as a repellent undercurrent..’ Even this well-heeled former government solicitor should be aware that some of the most vigorous supporters of Israel, Zionism and the IHRA are also some of the most notorious racist bigots in politics.  Donald Trump combines ardent support for Israel with anti-Semitism. His election campaign was widely condemned by American Jews for its use of anti-semitic stereotypes and subliminal messages. See Anti-Semitism is no longer an undertone of Trump’s campaign. It’s the melody.
The person who masterminded Trump’s campaign, Steve Bannon, is personally anti-Semitic and a supporter of the European far-Right and Tommy Robinson. The founder of the American alt-Right, the neo-Nazi Richard Spencer has even declared that he is a White Zionist
The policy passed by Liberty in opposition to the IHRA has nothing whatsoever to do with support for anti-Semitism or anti-Semitic hate speech. What it does do is support freedom of speech for opponents of Israeli apartheid. It is dishonest of Percival to suggest otherwise.
And to add insult to injury, this establishment lawyer that Liberty has taken under its wing goes on to state that ‘We have been very clear that Liberty is not actively campaigning against the IHRA definition, as it is not an institutional priority.’ That is obvious because there is not one single mention of the IHRA on Liberty’s website.
At a time when right-wing Labour Councils are adopting the IHRA, in consort with Tory councillors, with the specific intention of curtailing the rights of Palestine solidarity supporters, Liberty under its present leadership chooses to ignore its own policy and do nothing.
As if to emphasise her own disagreement with the policy Percival writes that
‘it’s often the case that members (and even sometimes our staff!) disagree with some of the organisation’s positions but remain engaged in an overall common purpose, and even work from within the organisation to change it.
Whilst no one expects staff to agree with every resolution, it is nonetheless their duty to give implement policy passed. The IHRA is being pushed hard by the present Conservative government, a government which is aligned in the European Parliament with far-Right anti-Semitic parties.  The IHRA is being used on campuses to prevent or seriously hinder Palestine solidarity campaigns.
Even the principal author of the IHRA or the Working Definition of Anti-Semitism, the American Jewish Committee’s Kenneth Stern has acknowledged that the IHRA is being used in ways that were never intended, as a means of chilling free speech. In testimony to the House of Representatives in November 2017, he warned that:
The definition was not drafted, and was never intended, as a tool to target or chill speech on a college campus. In fact, at a conference in 2010 about the impact of the definition, I highlighted this misuse, and the damage it could do.
Stern spokeabout how the IHRA was ‘was being employed in an attempt to restrict academic freedom and punish political speech’. One could argue that Stern was being hypocritical since the IHRA’s whole purpose was to render anti-Zionist criticism as  antisemitic.
Stern described how Zionist pressure groups in the US ‘argued that even if  the [court] cases lost, they had what seemed to them a positive benefit – they  chilled pro -Palestinian  expression.’Stern asked a question particularly relevant to the current debate. 
‘Imagine a definition designed for Palestinians. If  “Denying the Jewish people their right to self- determination, and denying Israel the right to exist” is antisemitism, then shouldn’t “Denying  the Palestinian people their right to self- determination,  and denying Palestine the right to exist”  be anti -Palestinianism?’
Stern described how the IHRA had been used to curtail free speech in Britain, listing the “Israel Apartheid Week” event which was cancelled by Central Lancashire University and the case of the Holocaust survivor who was required to change the title of  a campus talk by Manchester university after an Israeli diplomat complained that the title violated the definition.’  Stern described as ‘Perhaps most egregious’ of all the call on a university to conduct an inquiry of  a professor for ‘antisemitism’, based on an article she had written years before. Accurately describing what had happened as ‘chilling and McCarthy -like.’
As Jewish student Joanna Phillips wrotein Jewish News/Times of Israel Jewish students deserve a better definition of anti-Semitism’
Kenneth Stern … went as far as to write to the US House of Representatives urging them not to adopt this definition for American campuses. Jewish students need a tailored definition, written with the realities of modern universities in mind, not one designed for researchers.
Stern was prompted to write his letter after seeing the waves of censorship the definition unleashed within American campuses. The IHRA definition fails to properly distinguish between legitimate criticism of Israel and hatred of Jews disguised as anti-Zionism.
It would seem that Olivia Percival and Martha Spurrier, to whom I have written, also have difficulty distinguishing between anti-Semitism and criticism of Israel and Zionism. If Percival and Spurrier refuse to implement Liberty policy on the IHRA then they have no alternative but to resign.  Freedom of speech on university campuses and on Palestine is not a peripheral issue.
Below is my letter to Ms Percival and the policy that Liberty has adopted.
Tony Greenstein
Letter of Reply to Olivia Percival
Dear Olivia,
Thank you for your email of 2nd October concerning the decision of the Liberty AGM to oppose the International Holocaust Remembrance Alliance definition of anti-Semitism. I am surprised that you sent this from a ‘noreply’ email address. That is what my broadband supplier does. It indicates that you don’t wish to enter into dialogue on this subject. I have therefore dug out an email address for your Director and may post this more widely given your reluctance to be more open.
I am extremely disappointed by your response, which is almost apologetic for the fact that the motion was passed. Why else would you emphasise that members ‘and even sometimes our staff! disagree with some of the organisation’s positions’.  This strongly suggests that you intend to do your best to ignore the motion and do nothing about it. It also suggests that you disagree with the policy.
What is the purpose of passing policy at Liberty’s AGM if you and the staff immediately disregard it? The IHRA has already been used in this country to prevent an Israeli Apartheid Week at the University of Central Lancashire, to prevent Professor Richard Falk speaking on campuses and to impose restrictions on other pro-Palestinian events. Even the person who drafted the IHRA, Kenneth Stern, in testimony to the House of Representatives last November warned that:
‘The definition was not drafted, and was never intended, as a tool to target or chill speech on a college campus. In fact, at a conference in 2010 about the impact of the definition, I highlighted this misuse, and the damage it could do.’
I find particularly surprising your point that Liberty ‘both fervently supports free speech and fervently opposes anti-Semitism’ as if opposition to the IHRA means support for anti-Semitism. Viktor Orban, Hungary’s anti-Semitic Prime Minister certainly doesn’t share this position as his government fully supports the IHRA whilst lauding its war-time pro-Nazi ruler Admiral Horthy. You clearly do not understand why many people oppose both the IHRA and oppose racism and anti-Semitism.
Of the 8, yes 8, governments that have fully adopted the definition, (Macedonia, Bulgaria, Romania, Lithuania, Austria) 5 possess far-Right governments and one, Austria has a neo-Nazi party Heinz Christian Strache’s Freedom Party as the junior coalition partner.
You speak about the ‘intersection’ of free speech and opposition to anti-Semitism with talk about the ‘boundaries of free speech.’ You seem to be labouring under the misapprehension that opposition to the IHRA has something to do with free speech for anti-Semites or racists.  Let me disabuse you of this fact.
The IHRA ‘definition’ of anti-Semitism has nothing to do with opposing anti-Semitism and everything to do with conflating opposition to Zionism and support for the Palestinians with anti-Semitism. The IHRA is about defining critics of Israeli Apartheid as anti-Semitic. The demolition of Arab villages to make way for Jewish settlements and towns is inherent in what a Jewish State means.  According to the IHRA to make this point is anti-Semitic and you appear to go along with this nonsense. 
I find it disappointing that you haven’t grasped this elementary fact. Clearly you haven’t acquainted yourself with recent debates around the IHRA. Perhaps I can apprise you of them?
Professor David Feldman, who was Vice-Chair of the Chakrabarti Inquiry and  is Director of the Pears Institute for the Study of Anti-Semitism described the IHRA definition as‘bewilderingly imprecise.’ with its talk of anti-Semitism being a ‘certain perception which might be expressed as anti-Semitism’. 
Sir Stephen Sedley, who was a Judge in the Court of Appeal, besides being Jewish, wrote, in Defining Anti-Semitism that the IHRA‘fails the first test of any definition: it is indefinite.’ In what is the most concise critique of the IHRA yet, Sedley took it apart for its deliberate attempt to prevent any systematic critique of the Israeli state and Zionism.
Hugh Tomlinson QC in an Opinion declared, as did other lawyers, that the IHRA had a ‘potential chilling effect on public bodies which, in the absence of definitional clarity, may seek to sanction or prohibit any conduct which has been labelled by third parties as antisemitic without applying any clear criterion of assessment.’
Geoffrey Robertson QC, who is a renowned human rights lawyer likewise described the IHRA as likely to chill criticism of action by the Government of Israel and advocacy of sanctions as a means to deter human rights abuses in Gaza and elsewhere. Robertson described the IHRA as not fit for purpose’
Interestingly Robertson also finds, along with Sedley, that when it comes to genuine anti-Semitism, the IHRA actually raises the bar because ‘By pivoting upon racial hatred ... it fails to catch those who exhibit hostility and prejudice – or apply discrimination – against Jewish people for no reason other than that they are Jewish.’
There is a very simple definition of anti-Semitism the Oxford English Dictionary definition: ‘Hostility to or prejudice against Jews’ which catches attitudes that fall short of hatred. For example someone who says that he doesn’t hate Jews but he doesn’t want to live next to them or have his daughter marry a Jew is not, by the IHRA definition, anti-Semitic. 
I hope you and Liberty’s officials will revisit your obvious reluctance to embrace the decision of Liberty’s AGM. I realize that the IHRA is the consensus position of the British Establishment and that Liberty has traditionally seen itself as the liberal wing of that Establishment. However the IHRA is also a definition of anti-Semitism that anti-Semites such as the Polish and Hungarian governments feel comfortable with.  I should add that traditionally the British Establishment combined both pro-Zionism and anti-Semitism.
The IHRA is being used and has already been used in this country to close down debate on Palestine.  It has nothing to do with anti-Semitism. If free speech is not a concern of Liberty then what is the purpose of the organisation?
I look forward to your responding a tad quicker than the 6 months it took from my last post to you.
Yours sincerely,

Tony Greenstein 

          Kingston’s HyperX unveils the Cloud MIX wired+Bluetooth gaming headset      Cache   Translate Page      

Kingston‘s gaming division Hyper X has unveiled its latest gaming gear and it is a headset. Dubbed Cloud Mix, the headset is a hybrid gaming headset that can transmit by a wired...

The post Kingston’s HyperX unveils the Cloud MIX wired+Bluetooth gaming headset appeared first on Gizmochina.


          Comment on Hypertension in Scleroderma Requires Immediate Treatment, According To New Research by urus      Cache   Translate Page      
The initial test in the 1990's showed ceiling high ana's...higher than Lupus...higher than rhemotoid blood pressure 120/80 except my fingers were painful and palms unusally red like blood was floating underneath the skin. Went off of tea and the pain went away...took a year. History periodic heart pain like one season every 10 years with a galloping feeling and strong heart beat from age 14. I could outrun any boy, skate, climb etc. Late 1990's extreme reaction to cold...took a shower in 1 minute and slept inside an electrical blanket...body ice cold. Arms of the skin rested on the elbows. My body heat returned after ten years. I soaked myself in oil up to the neck for 3 days and the stiffness in the legs left but I had large sacs of ?pus or sugar? on my bum possibly due to blockage and oxygen could not be released? 120/80 still being maintained. Had a cancer operation due to a buildup of liquids in my neck and the doc gave me 5 years as I refused treatment due to the scleroderma. Interesting, an hour before the surgury my pressure went up to 178. Someone suggested that I cut back on drinking liquids to 8 cups a day from 20 - 40. I am border diabetic. 8 cups dehydration and my pressure returned to 120/80 maintained for the last 3 years. Had a fall in August...nothing serious. Went last night to the hospital thought I had appendicitis. Pain was so bad my husband had to pull my pants on. Scan was done...nothing. Blood pressure was 212/96. Had a very strong heart beat prior to hospital visit for about a minute and twice thought I was going to faint and wanted to vomit probably due to the pain pills. It just sort of snuck up on me. Gave myself a B 12 injecton purchased potassium caps and swallowed magnesium. 30 year gradually. At 72 I think I am normally healthy. Back to the diet...back to 8 cups a day. Reason I am writing is that my mother, Elsie Wigle, had a fall and died about 3 months later...perfect blood pressure...had antibiotic only once in her life and rarely visited a doc except for work related forms. Her blood pressure spiked into the 200's...the urethea closed. What if she never had the fall? Autopsy, in Hamilton, Ontario, showed a white spleen...like where did the blood go? I am still working as a superintendent. Inflammation seems to be something to take care of right away. Thus, I am taking 3 teaspoons of silver colitis a day.
          Merck Data at ESMO 2018 Congress Highlight Multiple Therapeutics with Potential to Transform Cancer Care      Cache   Translate Page      

DARMSTADT, Germany, Oct. 9, 2018 /PRNewswire/ --

Not intended for distribution in the USA, Canada or UK 

ESMO Abstract #

Avelumab: LBA6_PR, 659P, 1290P, 1291P, 1282P, 877P; M7824 (TGF β-trap/anti-PD-L1):1048O, 1463P, 1931P, 757P, 643P, 642P, 661P; tepotinib (MET kinase inhibitor): 1377O, 621PD, 698P; M6620: 1437P; M3814: 1845P; M7583: 1014PD; abituzumab: 487P; Erbitux®(cetuximab): 124P, 484P, 509P, 493P, 521P, 510P, 481P, 486P, 1057P, 1108P, 1068P, 1064P, 1293P

  • First presentation of Phase III data for avelumab (plus axitinib) in previously untreated, advanced kidney cancer
  • New and updated data for bifunctional immunotherapy M7824  
  • Results from Phase II trials for tepotinib, including in EGFR TKI-resistant NSCLC  
  • Additional pipeline data feature abstracts for a further four innovative agents across multiple tumor types with a significant patient need 

Merck, a leading science and technology company, today announced that new data from a variety of high-priority clinical development programs will be presented at the ESMO 2018 Congress (European Society for Medical Oncology Annual Meeting), October 19-23, 2018, Munich, Germany.

In the year that Merck celebrates its 350-year anniversary, abstracts at the congress represent a company record with eight therapeutic agents across 14 tumor types, reinforcing Merck's position at the forefront of clinical development in oncology.

"Our data at this year's European Society for Medical Oncology Congress expand our understanding of avelumab in renal cell carcinoma and other tumors, and demonstrate the headway we are making with our pipeline, including bifunctional immunotherapy M7824 and tepotinib," said Luciano Rossetti, Global Head of Research & Development for the Biopharma business of Merck. "We look forward to many more years of real and significant progress towards our vision of transforming the management and treatment of cancer."

Data from the Phase III study JAVELIN Renal 101, evaluating avelumab* in combination with axitinib, compared with sunitinib as initial therapy for patients with advanced renal cell carcinoma (RCC), will be presented for the first time during the Presidential Symposium at ESMO on Sunday, October 21, 2018 at 5:20 PM - 5:35 PM CEST. Avelumab is being jointly developed and commercialized with Pfizer. The results represent the first positive Phase III immunotherapy trial in combination with a tyrosine kinase inhibitor (TKI) in any tumor type, supporting Merck's interest in the potential use of avelumab in combination with currently approved therapies and novel agents. These results will be submitted for publication in a peer-reviewed journal. Other updates include new avelumab data in Merkel cell carcinoma (MCC) and advanced gastric or gastroesophageal junction (GEJ) cancer.

New data for M7824 will be presented from expansion cohorts of two ongoing Phase I clinical trials, including the first tumor-specific data for squamous cell carcinoma of the head and neck (SCCHN), biliary tract cancer, esophageal squamous cell carcinoma and esophageal adenocarcinoma. In addition, updated data for M7824 in patients with gastric cancer and non-small cell lung cancer (NSCLC) will be shared. M7824, discovered in-house at Merck, is an investigational bifunctional immunotherapy designed to combine a transforming growth factor β (TGF-β) trap by 'fusing' it with the anti-programmed death ligand-1 (PD-L1) mechanism. To date more than 650 patients with various types of solid tumors have been treated across the program with M7824 and the safety profile is consistent with that observed with other PD-1/PD-L1 inhibitors and previously described skin lesions (keratoacanthomas, SCC, hyperkeratosis) associated with TGF-β-inhibiting therapies.

Data for tepotinib** include results from three Phase II trials in epidermal growth factor receptor (EGFR) TKI-resistant NSCLC and advanced hepatocellular carcinoma, providing further evidence of this precision medicine's potential clinical activity in a range of tumors. Tepotinib, discovered in-house at Merck, is an investigational, oral MET inhibitor that is designed to selectively inhibit the oncogenic MET receptor signaling caused by MET (gene) alterations or MET protein overexpression.

Additional pipeline abstracts feature updated data from Merck's comprehensive DNA damage response (DDR) portfolio. These include results from a Phase I trial investigating M6620 (formerly VX-970) in combination with gemcitabine in patients with advanced NSCLC, and combined data from two Phase I trials of DNA-dependent protein kinase inhibitor, M3814. Results will also be shared from a Phase I/II trial of M7583, a Bruton's TKI, in patients with B-cell malignancies, as well as a retrospective analysis of the Phase I/II Poseidon study investigating abituzumab in patients with metastatic colorectal cancer (mCRC).

Data to be presented at the congress for Erbitux® will add to the growing body of real-world evidence supporting the therapy's role as a standard of care in RAS wild-type mCRC and first-line recurrent or metastatic SCCHN (R/M SCCHN), and for patients with locally advanced SCCHN (LA SCCHN) who may not be able to tolerate cisplatin-based regimens in full.  

*Avelumab is under clinical investigation for the treatment of RCC, MCC, CRC, gastric and GEJ cancer, and has not been demonstrated to be safe and effective for these indications. There is no guarantee that avelumab will be approved for RCC, CRC, gastric or GEJ cancer by any health authority worldwide.

**Tepotinib is the recommended International Nonproprietary Name (INN) for the MET kinase inhibitor MSC2156119J. Tepotinib is currently under clinical investigation and not approved for any use anywhere in the world.

Tepotinib, M7824, M3814, M7583, M6620 and abituzumab are under clinical investigation and have not been proven to be safe and effective. There is no guarantee any product will be approved in the sought-after indication by any health authority worldwide.

Notes to Editors 

Key Merck-supported abstracts slated for presentation are listed below. In addition, a number of investigator-sponsored studies have been accepted (not listed).

Title

Lead Author 

Abstract #

Presentation

Location




Date / Time
(CEST)







Avelumab





Late-Breaking Abstracts










JAVELIN Renal 101:

R Motzer

LBA6_PR

Sun, Oct 21,

Hall A2 -

a randomized,



4:30 - 6:10 PM

Room 18

phase 3 study of



(5:20 - 5:35 PM


avelumab +



 lecture time)


axitinib vs





sunitinib as





first-line





treatment of





advanced renal





cell carcinoma





(aRCC)










Poster Sessions










Avelumab

 T Doi

 659P

 Sun, Oct 21

 Hall A3 -

(anti-PD-L1) in



12:45 - 1:45 PM

Poster Area

Japanese patients




Networking Hub

with advanced





gastric or





gastroesophageal





junction cancer





(GC/GEJC): updated





results from the





phase 1b JAVELIN





Solid Tumor JPN





trial










Avelumab in

 P Nathan

 1290P

Sun, Oct 21,

Hall A3 -

European patients



12:45 - 1:45 PM

Poster Area

(pts) with




Networking Hub

metastatic Merkel





cell carcinoma





(mMCC): experience





from an ad hoc





expanded access





program (EAP)










Cost-effectiveness

M Bharmal

 1291P

Sun, Oct 21,

Hall A3 -

(CE) of avelumab



12:45 - 1:45 PM

 Poster Area

vs standard care




Networking Hub

(SC) for the





treatment of





patients (pts)





with metastatic





Merkel cell





carcinoma (mMCC)










Responder analysis

SP D'Angelo

1282P

Sun, Oct 21,

Hall A3 -

based on



12:45 - 1:45 PM

Poster Area

patient-reported




Networking Hub

outcomes (PROs)





and clinical





endpoints (CEPs)





in patients (pts)





with metastatic





Merkel cell





carcinoma (mMCC)





treated with





avelumab










First-line (1L) or

UN


Mon, Oct 22,

Hall A3 -

second-line (2L)

Vaishampayan

877P

12:45 - 1:45 PM

Poster Area

avelumab




Networking Hub

monotherapy in





patients (pts)





with advanced





renal cell





carcinoma (aRCC)





enrolled in the





phase 1b JAVELIN





Solid Tumor trial










Title

Lead Author

Abstract #

Presentation

Location




Date / Time
(CEST







M7824 (TGF β-trap/anti-PD-L1)





Proffered Paper Session










M7824

BC Cho

1048O

Mon, Oct 22,

ICM, Room

(MSB0011359C), a



2:45 - 4:15 PM

14B

bifunctional



(3:00 PM


fusion protein



 lecture time)


targeting PD-L1





and TGF-β, in





patients (pts)





with advanced





SCCHN: results





from a phase 1





cohort










Poster Sessions










Updated results of

 L Paz-Ares

1463P

Sat, Oct 20,

Hall A3 -

M7824



12:30 - 1:30 PM

Poster Area

(MSB0011359C), a




Networking Hub

bifunctional





fusion protein





targeting TGF-β





and PD-L1, in





second-line (2L)





NSCLC










Assessment of PD1/

T Mrowiec

1931P

Sun, Oct 21,

Hall A3 -

PD-L1



 12:45 - 1:45 PM

Poster Area

colocalization in




Networking Hub

hepatocellular





carcinoma (HCC)





using brightfield





double labeling





and quantitative





digital image





analysis










M7824

C Yoo

757P

Sun, Oct 21,

Hall A3 -

(MSB0011359C), a



12:45 - 1:45 PM

Poster Area

bifunctional




Networking Hub

fusion protein





targeting PD-L1





and TGF-β, in





Asian patients





with pretreated





biliary tract





cancer:





preliminary





results from a





phase 1 trial










M7824

B Tan

643P

Sun, Oct 21,

Hall A3 -

(MSB0011359C), a



12:45 - 1:45 PM

Poster Area

bifunctional




Networking Hub

fusion protein





targeting PD-L1





and TGF-β, in





patients with





post-platinum





esophageal





adenocarcinoma





(EAC): preliminary





results from a





phase 1 cohort










Phase 1 study

CC Lin

642P

Sun, Oct 21,

Hall A3 -

results from an



12:45 - 1:45 PM

Poster Area

esophageal




Networking Hub

squamous cell





carcinoma (ESCC)





cohort treated





with M7824





(MSB0011359C), a





bifunctional





fusion protein





targeting





transforming





growth factor β





(TGF-β) and





PD-L1










Updated results

 YJ Bang

661P

Sun, Oct 21,

Hall A3 -

from a phase 1



12:45 - 1:45 PM

Poster Area

trial of M7824




Networking Hub

(MSB0011359C), a





bifunctional





fusion protein





targeting PD-L1





and TGF-β, in





patients with





pretreated





recurrent or





refractory gastric





cancer










Title

Lead Author

Abstract #

Presentation

Location




Date / Time
(CEST)


Tepotinib





Proffered Paper Session










Phase 2 study of

 YL Wu

 1377O

Fri, Oct 19,

Hall A2,

tepotinib +



4:00 - 5:30 PM

Room 18

gefitinib



(4:51 PM


(TEP+GEF)



in lecture time)


MET-positive





(MET+)/epidermal





growth factor





receptor





(EGFR)-mutant (MT)





non-small lung





          IT Application business Analyst - SNC-LAVALIN INFRASTRUCTURE - Montréal, QC      Cache   Translate Page      
Job Description Part of the delivery portfolio, this position is responsible for oversight of the design and administrative functions of Hyperion applications...
From SNC-LAVALIN INFRASTRUCTURE - Tue, 09 Oct 2018 17:16:16 GMT - View all Montréal, QC jobs
          Kalapea Garage: кастом Ducati Hyperscrambler      Cache   Translate Page      
Kalapea Garage: кастом Ducati Hyperscrambler

Ducati Hyperscrambler — проект эстонской мастерской «Kalapea Garage». Клиент заказал скрэмблер для поездок по европейским маршрутам. В мастерской стоял разбитый мотоцикл Ducati Hypermotard 796, поэтому решение оказалось очевидным.
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Постоянный адрес публикации: bikepost.ru
          When life imitates art      Cache   Translate Page      
the baby pictured here is my aunt with my grandparents. This is the only photo I have of my mother's father. This aunt died last week at age 97.5. She was lucid to the end but her heart gave out. How did I find out? Facebook. I called the daughter of the only remaining aunt to get details. No one had told her or her mother. Are they having a funeral? Who knows. I feel bad because I didn't see her this summer. I kept dropping broad hints to my cousin but stopped short of inviting myself.

Allie turned five and had her party at a place full of playground equipment. 

the birthday girl looking the clone of her mom. Baby Hannah is more like Josh

We made our annual pilgrimage to Grand Rapids for their art competition. Every year less and less art. Now they will have it every other year. Still had fun walking around

these amethysts were part of a huge art work

This hand woven top was in a museum shop and is pricy. Still I want it. I am always buying thrift store stuff. Shouldn't I have something nice? I have plenty of black outfits to throw it over

Looks like a painting right? All embroidery with silk thread

some art was along the streets; some in the museums. Hotel lobby art


They had ten or so plastic crocs along the water. Art?

A MeToo political statement This is that pig Weinstein who forced himself on actresses if they wanted jobs. The lady in black has pepper spray at the ready as he tries to seduce the young one in white while grabbing his crotch

I haven't seen a praying mantis in 20 years or so. She cocked her head quizzically as I tried to take her photo. Where was she?

on the nearest joint of this praying mantis sculpture. Embiggen and maybe you can see her

this is as close as she will get to Poppa Steve

apple orchard time. I will have Maya all weekend. We will go here
I've been back nearly two weeks now from our SW adventure and trying to get back to normal. Still uncomfortably hot. I was dripping in sweat long after I finished running this morning. The days are shorter so I have to leave much later especially while biking. It is now been two years since I decided to do something about my obesity. How am I doing? Not as well as I would like but I guess it is a minor miracle that I was able to pull it off. Still people's first guess is that I must have some sort of scary wasting disease, not will power. As I type, I am 3 pounds over my lowest point last year. I would like to be 4-5 lower than I am now and I will shut up about it. Should be easy right? I was close before our vacation. Even though meals were far between, I couldn't exercise at my usual intensity.

Last week I had my 'welcome to Medicare' physical in which I had to answer all sorts of questions. Can I dress myself, feed myself? etc. My favorite: do I practice 'safe sex'? I left that one blank. I was asked to draw a clock complete with hands indicating a specific time. Also I was to memorize 3 words to recall 5 minutes later. Had an EKG. They said I had bradycardia. What's that? She said slow heart beat. I knew that: what's the cut-off? 50. Mine is 45. Well then you can't accuse me for being hyperthyroid (my TSH was low). Other than a low white blood count (???) I am the picture of health. Still I discussed genetic testing. Naomi's doctor thinks I was remiss for not testing for the BRAC1/2 deletion which is associated with the type of breast cancer I had especially as she is Jewish (and I am not) This partial test indicated that I may be a carrier for the BRAC2 which scared the life out of me but then I read about all the false positives. This will not be settled once and for all.  The BRAC1 is more associated with Jewish people but the BRAC2 with Scandinavian. Ancestry just refined its testing and as it turns out, I am much more Scandinavian than Irish. BRAC2 is an autosomal dominant gene which means one of my parents had to have it. It appears that if they did, it didn't manifest itself. If I do have the gene, each of my kids has a 50% chance of getting it from me. I could say they are all Steve clones with nothing from me but with their luck, they got this. And they could give it to their children. If they had it, what would it mean: 70% chance of breast cancer (and the aggressive kind I had) and 40% chance of ovarian which is impossible t detect until it's too late. The men are on the hook for the aggressive type of prostate and somewhat of a risk for pancreatic.

I didn't fit the guidelines when I was first diagnosed as I was a bit too old but now they changed the guidelines.

Today I went to a fashion show at this club for rich University woman that my grandparents belonged too. My grandfather was a successful physician and did teach at UM Medical school. I hadn't been there since he died. We were the youngest by far. We sat with a woman who was a neighbor of my grandfather's . Small world. They were just reminiscing about him lately. He would have been 128 years old if still alive. They called his house Mount Vernon not Tara as I had read about it. All of the other houses in their fancy neighborhood were designed by innovative architects whereas my grandfather made a house out of sugar cubes and told the architect to make it like that.  As for the clothes, they were nice but pricy. I do buy them at the fancy thrift store as they seem to have some partnership deal with them but I wasn't going to share that with the rich ladies.



          QED      Cache   Translate Page      

Quantum electrodynamics, commonly referred to as QED, is a quantum field theory of the electromagnetic force which approach visualizes the force between the electrons as an exchange force arising from the exchange of virtual photons. QED was the first successful quantum field theory, incorporating such ideas as particle creation and annihilation into a self-consistent framework. The development of the theory was the basis of the 1965 Nobel Prize in physics, awarded to Richard Feynman, Julian Schwinger and Sin-itero Tomonaga.

Source - HyperPhysics

Sound design by Billain.

hyperbinary.com
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Cast: Hyperbinary

Tags: led, qed, dynamics, hyperbinary, billain, cluster, wave and ledtubes


          Comment on Goodbye to AHELO? by dothalledly      Cache   Translate Page      
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          Gear.Club Unlimited 2 sortira le 4 décembre      Cache   Translate Page      

Paris, le 9 Octobre 2018 - Microïds et Eden Games dévoilent de nouvelles images pour Gear.Club Unlimited 2 et confirment sa sortie mondiale au 4 décembre 2018. Ce jeu de course exclusif à la Nintendo Switch offrira aux joueurs un terrain de jeu immense avec plus de 3000 km de course. A flanc de montagne, dans un parc naturel, en plein désert ou en bord de mer, ils découvriront 250 courses réparties entre championnats, missions et défis.

Lors de leur progression, les joueurs devront améliorer leurs véhicules pour gravir les marches du classement grâce aux 7 ateliers de leur garage aménagé - le performance shop. Toujours dans leur performance shop, ils pourront customiser visuellement leurs véhicules en leur apposant des peintures, des stickers personnalisés, en modifiant leurs pare-chocs, capot, jupes latérales ou aileron. Gear.Club Unlimited 2 proposera un roster de 51 voitures issues de 22 constructeurs prestigieux, dévoilé ci-dessous !

Liste des voitures présentes dans le jeu

Constructor

Name

Acura

NSX 2016

AC

378 GT Z

Alfa Roméo

4C

8C Compitizione

Giulia II QV

Giulietta III QV Squadra Corse

Bentley

Continental GT V8 S

BMW

M2 Coupé

M4 Coupé

M6 Coupé

Z4 Roadster

Bugatti

Veyron GrandSport

Chevrolet

Camaro 1LS

Camaro 50th

Corvette Stingray

Dodge

Challenger RT/Scattpack

Viper SRT

Fiat

500 Abarth 695 Biposto

Ford

Focus RS 2016

Mustang GT 2015

GTAMotor

SpaniaGTA

Jaguar

Ftype R AWD

Koenigsegg

Agera RS

Lotus

3-Eleven Race

Elise 220 Cup

Evora 400

Exige S

Mazzanti

Evantra

McLaren

12C

570S

570S GT4

675LT

720S

P1

Mercedes-AMG

C63 S

GT S

SLS BlackSeries

Mini

Cooper S JCW (F56)

Nissan

370z

370z Nismo

GTR

GTR Nismo

Pagani

Huayra Roadster

Zonda Cinque

Porsche

718 Boxster GTS

911 GT2 RS

918 Spyder

Ruf

CTR 3

RT12 R

W-Motors

Fenyr Supersport

Lykan Hypersport

 

Plus d'informations sur les modes multijoueurs en ligne et local seront dévoilées très prochainement.
 
Gear.Club Unlimited 2 est développé par Eden Games et édité par Microïds, il sera sur Nintendo Switch en version physique et digitale le 4 décembre 2018 sur tous les territoires. Le jeu classifié PEGI 3 / ESRB E for Everyone / USK 0. disponible

...
          Hallelujah, Black Folks! Jesus Can Lower Your Blood Pressure, Study Finds      Cache   Translate Page      
A study suggested that practicing religion can improve efforts to reduce hypertension in Black people.
          Borderlands 2 VR Announced for PlayStation VR      Cache   Translate Page      



Borderlands 2 VR Gets All Up in Your Face on PlayStation VR

2K and Gearbox Software today announced Borderlands 2 VR, that will bring the critically-acclaimed and genre-defining shooter-looter franchise to VR for the first time on December 14, 2018 on PlayStation VR. Fans who pre-order Borderlands 2 VR will also be rewarded with instant access to a dynamic PlayStation Theme featuring the game’s four iconic Vault Hunters – Salvador, Maya, Axton and Zer0.

Developed by Gearbox Software, Borderlands 2 VR brings the iconic world of Pandora to life like never before. Fans will virtually become a treasure-seeking Vault Hunter, grab 87 bazillion guns, and face off against the galaxy’s most charming psychopathic dictator, Handsome Jack, to free Pandora from the corrupt Hyperion Corporation.


Key Features

Virtually Step onto Pandora: Step into the boots of a treasure-seeking Vault Hunter armed with 87 bazillion possible guns on a quest to line your pockets with loot and free Pandora from Handsome Jack’s clutches. Blast bandits with real-world aiming, punch bullymongs in the mouth, find the perfect gun inside a life-sized treasure chest and inspect it from every angle. Catch-aRide and race across Pandora in first-person view and experience the thrill of a psycho running toward you with grenade in-hand yelling, “Boom time!”

Virtually Slow Time: Borderlands 2 VR includes new features unique to the VR experience to empower Vault Hunters in their fight against Handsome Jack. With Bad Ass Mega Fun Time (aka BAMF Time), players can use this new slow-mo ability to literally slow the speed of the game temporarily to set up their next attack. In addition, with the option to Teleport, players can glide across Pandora as gracefully as Claptrap (if he had grace).

Become a Virtual Vault Hunter: Take on the role of one of four playable classes – Siren, Commando, Gunzerker and Assassin – each with unique combat styles and updated skills that leverage the new VR functionality, including the new BAMF Time ability. Whether crushing enemies with Maya’s Siren powers, calling in Sabre Turret reinforcements as Axton, feeling the heft of dual-wielded machine guns as Salvador, or the satisfying swing of Zer0’s sword in an enemy’s back, Borderlands 2 VR immerses players like never before.

Experience Virtual Improvements: For the first time ever, players can experience the sublime exhilaration of driving around the Borderlands in first-person perspective – accelerating and steering with the joystick and aiming the vehicle’s weapons with their headset. With the use of the motion controllers and headset, players can interact with the menu systems in a new and intuitive way for the platform, easily navigating through the menus by pointing, clicking, dragging and dropping. Players will also have the choice of preferred movement styles. Whether that’s the VR popular pointed-teleportation, or the classic direct movement style with joysticks – your experience should feel good for VR and true to form of classic Borderlands.

Get Virtually Rich: Borderlands VR brings shoot-and-loot mechanics to VR with bazillions of procedurally-generated guns and gear, each with their own capabilities and modifiers. Procedurally-generated shields, grenades, relics, class mods and more round out your Vault Hunter’s arsenal for maximum power and mayhem.


Borderlands 2 VR will be available on December 14, 2018 for the PlayStation VR. Borderlands 2 VR is single-player only. For more information, please visit the official Borderlands website.

          Principal Financial Analyst - Financial Systems      Cache   Translate Page      
MA-Braintree, Would you like to be the Finance Expert in relation to Hyperion and Oracle IT Systems for one of the most successful medical device and healthcare companies in the New England area? Can you be that key link between transferring data financial data between Hyperion and Oracle? Would you like to work at a publicly-traded global business with new expanding product lines and services? If so, please ap
          MapleStory 2 “player numbers growing very fast”, lots of bots      Cache   Translate Page      

MapleStory 2 player numbers growing very fastMapleStory 2 is currently in its headstart phase, with the official launch planned for tomorrow, October 10, and Nexon has revealed some details...

A post from Free MMO Station


          Huawei hat Turbo Boost, Oppo wohl bald Hyper Boost      Cache   Translate Page      
Kurzmeldung: Turbo Boost ist ein neues Feature, welches Huawei in diesem Jahr mit dem Honor Play eingeführt hat. Man hat beim Update von der EMUI […]
          Customer Service Specialist      Cache   Translate Page      
CA-San Jose, Company Information: Quanta Cloud Technology (QCT,LLC) is a global datacenter solution provider. We combine the efficiency of hyperscale hardware with infrastructure software from a diversity of industry leaders to solve next-generation datacenter design and operation challenges. QCT, LLC serves cloud service providers, telecoms and enterprises running public, hybrid and private clouds. Product li
          Comment on Opinion: In District 8 race, Candidate Mary Kay Lacey distorts City Councilwoman Lori Droste’s position by hyper_lexic      Cache   Translate Page      
Interesting because I’ve watched multiple city council meetings and I’ve repeatedly seen her be the main person working for some sort of consensus across a fairly divided council.
          Comment on Opinion: In District 8 race, Candidate Mary Kay Lacey distorts City Councilwoman Lori Droste’s position by hyper_lexic      Cache   Translate Page      
Obviously there’s a lot of passion all sides, and social media of all kinds is poisonous... so I apologize on the part of my allies. That said... I think we come from similar backgrounds (BHS grads if I remember correctly). Definitely my motivation is driven from this background and how Berkeley has changed. If you’re a D8 voter I definitely suggest you look closely at which candidate is closer to this vision.
          Hallelujah, Black Folks! Jesus Can Lower Your Blood Pressure, Study Finds      Cache   Translate Page      
A study suggested that practicing religion can improve efforts to reduce hypertension in Black people.
          Skincare Tools & Do-It-Yourself Skincare :: RE: LED Lights for Skin - Best Watts, Wavelengths?      Cache   Translate Page      
Author: beauty_fan
Posted: Tue Oct 09, 2018 9:57 am (GMT -7)

I wouldn't use anything meant for grow operations -- they don't have to worry about temperature. The wattage of the LED you posted is higher than what I've typically seen for LED devices. More watts = higher temperature = hyper pigmentation risk for healing skin. If you just spent money on plasma procedures, take the extra measure and spend money on a quality LED device.

          Skincare Tools & Do-It-Yourself Skincare :: RE: sebaceous hyperplasia      Cache   Translate Page      
Author: hemp
Posted: Mon Oct 08, 2018 2:21 pm (GMT -7)

Yes ACP I believe is the same thing.

I guess some things are cheaper up in Scotland.

That's great news for you as you will be able to keep on top of them without it hitting you too hard financially.


          Skincare Tools & Do-It-Yourself Skincare :: RE: sebaceous hyperplasia      Cache   Translate Page      
Author: happycat01
Posted: Mon Oct 08, 2018 9:28 am (GMT -7)

I had my treatment done in Edinburgh. It wasn't called ckin classic,they call it Advanced Cosmetic Procedure and it was explained to me (but can't quite remember exactly) that it uses a combination of heat and something else that goes through the thin probe to destroy the sebaceous gland and the tissue around it.

          With MBS On The Ropes–Is Saudi Arabia The Next Failed State?      Cache   Translate Page      
Reports are growing that Muhammad bin Salman, Saudi Arabia’s hyperactive crown prince, is losing his grip. His economic reform program has stalled since his father, King Salman, nixed plans to privatize 5 percent of Saudi Aramco. The Saudi war in Yemen, which the prince launched in March 2015, is more of a quagmire than ever […]
          Enough Crocodile Tears For Khashoggi—The Saudi Evil Goes Far Deeper      Cache   Translate Page      
Every ten minutes a child in Yemen starves because of the famine caused by the Saudi, UAE, U.S. and UK war on the country. The renewed attack on the harbor of Hodeidah and hyperinflation over the recent months have doubled the prices of food and gas  Most people in Yemen no longer have the income […]
          We Tried Out The Prime-Rated Strapless Bras      Cache   Translate Page      

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          How you can be Happier in three Straightforward Steps      Cache   Translate Page      
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          The Pixel three: Every thing You Want To Know About Google’s New Telephone      Cache   Translate Page      

It has a robotic name screener, a bigger show, and plenty of new digital camera options. View Complete Publish › Supply hyperlink
          So You Assume You Can Prepare dinner? Let's Discover Out.      Cache   Translate Page      

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          30 New And Restricted Version Magnificence Merchandise That Belong In Your Buying Cart ASAP      Cache   Translate Page      

Prepare, trigger there’s a lot of new goodies from City Decay, Fenty Magnificence, Laneige, Glow Recipe, Shiseido, Beautyblender, Summer time Fridays, Sunday Riley, and extra coming your method! View Whole Publish › Supply hyperlink
          24 Issues That'll Make You Name Your Mother and father And Say You Love Them      Cache   Translate Page      

Like proper now. View Whole Submit › Supply hyperlink
          Mother and father of the Web Are Sharing Classes They Taught Their Youngsters That Hilariously Backfired      Cache   Translate Page      

Household They undoubtedly want they might have a re-do on a few of these. They’re good examples of what NOT to do when making an attempt to show issues to youngsters. Supply hyperlink
          7 drones with superlong flight occasions      Cache   Translate Page      

Right now, your common shopper drone can fly for less than round 10 to 25 minutes. However the occasions they’re a-changin.’ Listed here are seven drones which buck the system with tremendous lengthy flight occasions. The publish 7 drones with superlong flight occasions appeared first on Digital Tendencies. Supply hyperlink
          Comment on Blog Entry #11 The NFL and Player Concussion by Print leaflets manchester      Cache   Translate Page      
<strong>Print leaflets manchester</strong> [...]that will be the end of this write-up. Here you will locate some sites that we consider you will appreciate, just click the hyperlinks over[...]
          Hallelujah, Black Folks! Jesus Can Lower Your Blood Pressure, Study Finds      Cache   Translate Page      
A study suggested that practicing religion can improve efforts to reduce hypertension in Black people.
          Comment on SO. CAL JAMS by Android Apps Download      Cache   Translate Page      
<strong>Android Apps Download</strong> [...]that is the end of this article. Here you will come across some sites that we think you will value, just click the hyperlinks over[...]
          Gene expression in response to optical defocus of opposite signs reveals bidirectional mechanism of visually guided eye growth      Cache   Translate Page      
by Tatiana V. Tkatchenko, David Troilo, Alexandra Benavente-Perez, Andrei V. Tkatchenko Myopia (nearsightedness) is the most common eye disorder, which is rapidly becoming one of the leading causes of vision loss in several parts of the world because of a recent sharp increase in prevalence. Nearwork, which produces hyperopic optical defocus on the retina, has … Continua la lettura di Gene expression in response to optical defocus of opposite signs reveals bidirectional mechanism of visually guided eye growth
          10/10/2018: News: ‘I’d have gone off the rails’      Cache   Translate Page      

YouTube star Jessica McCabe says she would have “gone off the rails” if she hadn’t taken medication to control her attention deficit hyperactivity disorder (ADHD). McCabe, an American actress whose YouTube channel How to ADHD has 218,000 followers,...
          Regional dental firm Great Expressions protects distributed data with lower complexity thanks to amalgam of Nutanix HCI and Bitdefender security       Cache   Translate Page      

Modern dentistry depends on more than good care. It also demands rapid access to data and applications. For a rapidly growing dental services company -- consisting of hundreds of dental offices spread across 10 US states -- the task of managing all of its data availability, privacy, and security needs grew complex and costly. The nextBriefingsDirect security innovations discussion examines howGreat Expressions Dental Centers found a solution by combininghyperconverged infrastructure (HCI) withad Read More..
          10/10/2018: Fashion: 5 SUMMER WARDROBE UPDATES      Cache   Translate Page      

1. ORANGE ZEST Move over Millennial pink and Gen Z yellow, the next colour you’ll be seeing everywhere is one we’re naming hyperactive orange. You know, kind of how you feel once you’ve downed a few glasses of Fanta. Don’t worry, there is a...
          "Guess this is all just unnecessary PR hype"      Cache   Translate Page      

Priestmangoode creates full-scale prototype of "spaceship-like" Hyperloop capsule

In this week's comments update, readers are confused about the shape of a prototype Hyperloop capsule, and blown away by plans for the Wuxi Show Theatre in China. Read more


          The Core i9 Gaming Benchmarks Intel Commissioned Against AMD Are a Flat Lie - ExtremeTech      Cache   Translate Page      

ExtremeTech

The Core i9 Gaming Benchmarks Intel Commissioned Against AMD Are a Flat Lie
ExtremeTech
Everyone in the enthusiast community knows that manufacturer-provided benchmarks must be taken with a grain of salt. One could write a book on the various ways that companies tend to shade the truth to paint their own products in a positive light. Some ...
Intel derailed its i9-9900K launch with 2 unforced errorsVentureBeat
Intel's 9th-gen Core i7-9700K abandons Hyper-Threading: What it could mean for performancePCWorld
What Intel's New Processor Line Means for Desktop BuyersPCMag
Tom's Hardware -Forbes -Threatpost -EE Times
all 336 news articles »

          25B Information Technology Specialist      Cache   Translate Page      
ID-POCATELLO, 25B Information Technology Specialist Job Description Everything begins with solid communications. And in this hyper-networked world, that won't change anytime soon. So set yourself up in a promising civilian career by learning the Information Technology skills you need in the Army National Guard. Computers are essential to every division of the military. In the Army National Guard, you will learn
          WH Volleyball Records Road Win      Cache   Translate Page      



Whitman-Hanson volleyball traveled to Plymouth North Tuesday for a league match and the Panthers won 3-0. The set scores were 25-17 (WH), 26-24 (WH) and 25-20 (WH).  The Panthers began the match with high energy and persevered through a close second set. The Panthers were especially inspired by their science teacher Mr.Dukeman, who pumped them up with words of encouragement before the match. Senior middle Erin Leahy was on fire all match with 9 total kills. Junior tri-captain right side Olivia Martin got the team going with a strong kill and aggressive play in the first set. Junior tri-captain libero Nicole Scott recorded 16 digs in the match. The Panthers are 4-7 overall, 4-6 in league play and host Duxbury Thursday 10/11.




          Sales Director      Cache   Translate Page      
CA-San Jose, Company Information: Quanta Cloud Technology (QCT, LLC) is a global datacenter solution provider. We combine the efficiency of hyperscale hardware with infrastructure software from a diversity of industry leaders to solve next-generation datacenter design and operation challenges. QCT serves cloud service providers, telecoms and enterprises running public, hybrid and private clouds. Product lines
          Comment on Fed Killing the Economy – John Williams by Dan      Cache   Translate Page      
Yes, Greg, Williams is "STILL" forecasting USD HYPER INFLATION. No need to ask him that question AGAIN. But you might want to remind him that he has been forecasting that event every year now for the past 6+ freaking years. No doubt ONE DAY, he will be proven correct ! But if he were a "REAL" genius, as you claim he is, he would have instructed his subscribers to DUMP all but the INSURANCE part of their precious metals holdings back in 2011-2012 (at or close to the top), and PLOWED ALL that dough into the STOCK MARKET. Because the STOCK MARKET has BEATEN the CRAP out of the precious metals over the last 7 years. And you DON'T need to be a GENIUS to figure that out.
          Inside Sales Coordinator      Cache   Translate Page      
CA-San Jose, Company Information: Quanta Cloud Technology (QCT,LLC) is a global datacenter solution provider. We combine the efficiency of hyperscale hardware with infrastructure software from a diversity of industry leaders to solve next-generation datacenter design and operation challenges. QCT serves cloud service providers, telecoms and enterprises running public, hybrid and private clouds. Product lines i
          Sales Engineer (Multiple Positions)      Cache   Translate Page      
CA-San Jose, Company Information: Quanta Cloud Technology (QCT,LLC) is a global datacenter solution provider. We combine the efficiency of hyperscale hardware with infrastructure software from a diversity of industry leaders to solve next-generation datacenter design and operation challenges. QCT, LLC serves cloud service providers, telecoms and enterprises running public, hybrid and private clouds. Product li
          Comment on How to Stop Jihad by Dennis      Cache   Translate Page      
A hyper-psychological analysis of what motivates the Jihad's to violence. Yet, no answer to how to turn such conduct off. I am afraid that after 1400 years, nothing can turn off this heinous conduct. That, to me, is the reality that we face. Since the leaders of the Islamic world will not reject the parts of their belief system that promotes and condones violence against all non-believers, and refuse to be good neighbors and all that we here in the free world consider decent, another approach must be considered. I suspect that another approach might be economic. If we can cut out the oil profits that fuel the radical Islamic regimes, just maybe we can then convince their leaders that they must abandon their thirst for violence, or get their people to overthrow the tyrants that run their countries as dictators. The only other way is violence thru war like conduct, and I would hope it would not come to that, as violence never seems to accomplish an appropriate final solution to anything that has a psychological element.
          BEER!      Cache   Translate Page      
the left seems to mix up Catholics with Baptists, in that they hyperventillated when Mr. K said he liked to drink beer.

You could almost hear them thinking: evil evil evil.

Puritans think one has to be perfect, abstain from good things (i.e. food like pizza and chocolate) and abstain from alcohol.

but Catholics? beer is fine. I mean, Jesus' first miracle was changing water into wine so that the wedding party guests could celebrate, and all good things of life remind us of the joys of heaven.

which is why there is an old saying that Beer is proof that God loves us and wants us to be happy.

Actually, in Catholicism it is a sin to be falling down drunk, or to use it if one knows it makes you mean, or to get drunk and drive, but it's find to have a few beers to get merry.

As this photo shows. we have it on the highest authority.

via theratzingerforum.yuku.com



and St Brigid of Ireland changed water into beer for her lepers. This poem is attributed to her (probably inspired by her).

I'd like to give a lake of beer to God.
I'd love the heavenly
Host to be tippling there
For all eternity.

I'd love the men of Heaven to live with me,
To dance and sing.
If they wanted, I'd put at their disposal
Vats of suffering.

White cups of love I'd give them
With a heart and a half;
Sweet pitchers of mercy I'd offer
To every man.

I'd make Heaven a cheerful spot
Because the happy heart is true.
I'd make the men contented for their own sake.
I'd like Jesus to love me too.

I'd like the people of heaven to gather
From all the parishes around.
I'd give a special welcome to the women,
The three Marys of great renown.

I'd sit with the men, the women and God
There by the lake of beer.
We'd be drinking good health forever
And every drop would be a prayer.
so yes, the Simpson's got it right:





beer goes way back in history:



 Indeed, some historians link beer making and bread, but argue which came first.

but this BBC film argues that beer was the greatest invention of civilization:





          شركة Intel تكشف عن الجيل التاسع من معالجاتها و موعد إطلاقها      Cache   Translate Page      

كشفت شركة Intel رسميًا عن مواصفات مُعالجات الجيل التاسع الخاصة بها، كما كشفت عن مواعيد إصدارها و أسعارها. أبرز المُعالجات الجديدة هو معالج الـ i9-9900K، و الذي يحتوي على 8 أنوية، و يدعم تقنية الـ Hyper-Threading، كما يعمل بسرعة 5.0 GHz. كذلك أكدت الشركة أن مُعالج الـ i9-9900K يحتوي على Cache بمساحة 12 Mb، و […]

The post شركة Intel تكشف عن الجيل التاسع من معالجاتها و موعد إطلاقها appeared first on SK Productions News Center.


          Account Manager      Cache   Translate Page      
WA-Bellevue, Company Information: Quanta Cloud Technology (QCT, LLC) is a global datacenter solution provider. We combine the efficiency of hyperscale hardware with infrastructure software from a diversity of industry leaders to solve next-generation datacenter design and operation challenges. QCTserves cloud service providers, telecoms and enterprises running public, hybrid and private clouds. Product lines i
          Chef de Département Produits Frais H/F      Cache   Translate Page      
En tant que Chef de Département Produits Frais, vous avez pour missions les suivantes :      * Assurer la gestion quotidienne de votre périmètre : Tenue des rayons, gestion de la démarque, organisation du travail des équipes,     * Définir les assortiments, les implantations, ainsi que les tarifs de vos rayons en respectant la politique commerciale de l'enseigne,     * Planifier la promotion sur votre périmètre (achat de collections), organiser la mise en place des opérations calendaires majeures et en analyser les résultats afin d'ajuster les commandes pour les années suivantes,     * Négocier avec vos fournisseurs les meilleures conditions,     * Encadrer votre équipe avec exigence et bienveillance, l'objectif étant la stabilité des Collaborateurs et leur montée en compétences et faire évoluer les potentiels,     * Garantir le respect des différentes législations en vigueur, tant en matière de droit du commerce que de droit du travail,     * Participer activement à la construction des budgets de votre Département,     * Participer activement à la vie de l'hypermarché, en étant pro-actif et force de proposition.
          La césarienne, ce mal qui frappe les femmes enceintes !      Cache   Translate Page      
Il est paradoxal de constater que, de nos jours, dans ce monde de science et de technologies où la Médecine est hyper développée avec des progrès incontestables …, que des femmes accouchent en nombre incommensurable et quotidiennement par césarienne. C’est-à-dire; accoucher par intervention chirurgicale que les Gynécologues et Sages-femmes sont obligés de recourir banalement pour …
          Commentaires sur Comment aider un enfant surdoué à maîtriser son hypersensibilité ? par Maman zebre      Cache   Translate Page      
Difficile de trouver des solutions concrètes.je trouvé beaucoup de descriptifs mais peu de conseils...merci d'avance si vous pouvez m'apporter votre aide. Maman de 4 petits zèbres entre 21mois et 6 ans
          Commentaires sur Pourquoi l’hypersensibilité des enfants surdoués entraîne-elle souvent des difficultés à l’école ? par Grossot      Cache   Translate Page      
Bonjour . Maman de deux filles précoces font la dernière en classe de 3ème développe une phobie scolaire, je suis en train de travailler avec le collège sur un aménagement de son temps de cours afin de gérer ses angoisses . Mais effectivement, on ne parle jamais de leur grandes capacité d'analyse, de discernement et d'empathie. .. C'est regrettable.
          Commentaires sur L’hyperstimulabilité émotionnelle, comment l’identifier pour mieux y faire face. par Anne laure Carriorbe      Cache   Translate Page      
Bonjour, Je pense qu il serait sans doute profitable de rechercher la raison des difficultés scolaires de votre fille. Les causes sont tres nombreuses et parfois difficiles a diagnostiquer. Faire le wisc 5 pourquoi pas , cela vous permettra d ecarter ou non la precocite/certaines dyspaxies etc. Le parcours"habituel" est : Psychomotricien/psychologue/ophtalmo pour verifier les saccades occulaires etc... Bon courage
          Commentaires sur Précocité et hypersensibilité, comment en faire une force ? par Anonyme      Cache   Translate Page      
Bonsoir. Mon fils est malheureux. Il est éteint. Il reste de marbre. Il ne fait plus rien à l'école c'est une catastrophe. J'ai peur pour lui. Comment l'aider ? Savoir ce qu'il pense ?
          Commentaires sur L’hyperstimulabilité émotionnelle, comment l’identifier pour mieux y faire face. par Charlotte      Cache   Translate Page      
Bonjour, Je suis maman d'un petit garçon de 4 ans et demi, que je pense précoce...comme pour beaucoup de parents sur ce site, j'ai un enfant hypersensible, très intelligent et en avance sur les apprentissages (s'est mis à écrire spontanément il y a 1 mois et demi, reconnait l'alphabet et a compris les additions...), s'intéresse à tout, pleure comme une sirène quand la situation peut paraître minime. Je suis venue dans les Vosges pour l'inscrire dans une école Montessori l'année dernière, qui, pour finir, ne lui a pas vraiment convenu (il était terrorisé par un enfant qui avait des troubles du comportement)...je l'ai déscolarisé, gardé tout le dernier trimestre à la maison...je l'ai réinscrit à l'école publique à mi temps cette année. C'est mieux que l'année dernière, mais il dit encore qu'il ne veut pas aller à l'école. Je vois bien qu'il s'y ennuie. Pouvez vous s'il vous plait me parler de l'accompagnement à la parentalité dont vous parliez, au sujet de cette école alternative en Ardèche? Merci d'avance, Charlotte
          La chute se poursuit pour l’indice du secteur bancaire grec !! Déjà -52,8 % en 5 mois !!      Cache   Translate Page      

 L’indice du secteur bancaire grec continue de plonger !! Déjà -52,8 % en 5 mois. Rappelons que depuis 2015, le cours des banques grecques a chuté de près de 97 %. Artus: “On prête aux grecs l’argent qui leur permet de nous rembourser. C’est une absurdité totale” Grèce: Au pays de l’ultra-crise A l’intention des lecteurs du site BusinessBourse Nous sommes à la veille d’un tournant majeur dans l’économie mondiale. Pour les très rares personnes qui ont des actifs à protéger, le moment est venu de sortir des bulles d’actifs, comme je le recommande depuis longtemps. Il est également temps de détenir de l’or et de l’argent physique comme assurance pour son patrimoine. Les métaux précieux atteindront des niveaux sans précédents, voire non envisageables aujourd’hui avec l’hyperinflation. Pour ceux qui pensent avoir peu de moyens, rappelez-vous que vous pourriez acheter 1 gramme d’or par mois, ou plus, ce qui coûte aujourd’hui 43 $. Au fil du temps, cela vous permettra d’accumuler un important pécule. Goldbroker propose une solution simple et sûre pour acheter de l’or physique et parer à la criseGoldBroker, pour un stockage sécurisé en nom propre hors du système bancaire de vos métaux précieux.

The post La chute se poursuit pour l’indice du secteur bancaire grec !! Déjà -52,8 % en 5 mois !! appeared first on BusinessBourse.


          Young Hamlet and Shorthand      Cache   Translate Page      

The Shakespeare Conference: SHK 29.0341  Tuesday, 9 October 2018

 

From:        Gerald E Downs <jerrydowns@aol.com>

Date:         October 9, 2018 at 2:08:57 AM EDT

Subject:    Re: Young Hamlet and Shorthand

 

Following Laurie Maguire and Madeleine Doran (MLS reprint, 1935), Terri Bourus cites G. N. Giordano-Orsini (Library, 1933) to dismiss Thomas Heywood’s contemporary claim that If You Know Not Me (1605) was reported by shorthand. Because Bourus misquoted G-O to ask whether pirates ‘first drew the plot’ to report the play, I’ve belatedly read his interesting article.

 

Heywood’s England’s Elizabeth (1631) retraces the events, where “practically every scene in the play has its counterpart in the prose history, and even the wording is sometimes identical” (G-O, 316). Both are based on Foxe’s Book of Martyrs. The plot of the play is then most likely Heywood’s.

 

G-O gives a fair account of the drama; his primary observation is that four characters’ lines are superior to those when none of the four is on or near the stage. Elizabeth’s ‘usher’ Gage is especially (though not historically) prominent and influential. The ‘MR inference’ is that actors could less ably reconstruct parts with which they weren’t familiar—therefore, the more mis-lined, unmetrical, unpoetic, or senseless text proves that ‘Gage’ was an actor-reporter. G-O does not explain his concluding statement to that effect:

 

As a result of this summary it seems fair to claim that either Heywood’s assertion that it was by stenography that his play was put in print must be regarded as mistaken, or if stenography was used it was supplemented from the memories (and perhaps from the ‘parts’) of two or more of the actors.

 

Doran (writing two years later in conjunction with MR-arm-twisting MSR General Editor Greg) remarks:

 

Even though the observation does not always hold good, the characteristic is sufficiently marked to render the theory plausible, and to suggest that the report did not depend exclusively on shorthand, an agency that could hardly produce such a result.

 

Thus Giordano’s worthy observations about the text are wasted: we are to suppose that Heywood (the author) had no real knowledge of his play’s transmission. Heywood was there; he knew the players and he knew repertory; he read a travesty of his own work. He knew too that shorthand wasn’t the ‘agency that produced’ what shorthand obviously recorded very well—the actors’ spoken words.

 

Shorthand reporting never depended exclusively on shorthand. Only the strange assumption that actors were uniformly part-perfect allows the denial of Heywood’s testimony. When one reads the Q1 reprint and G-O’s analysis as if actors in performance account for all dialogue, the resultant text accommodates shorthand (& vice-versa). Several roles were well done; many, especially bit parts, weren’t. Punctuation is faulty, verse is hammered hyper- and hypo-, prose is lined as verse, etc. This playtext is actually good evidence of how playing was done—and recorded. Memory didn’t supplement shorthand; it supplied a whole text, whole cast, in performance, as Heywood knew full well.

 

I’ve taken new interest in The and A Shrew, largely because of the Q2/Q1 Hamlet analogy. After a little reading (Duthie, 1943; a late edition, etc.) I hope to confirm the general knowledge that A derives mostly from The, and that A and maybe even The are shorthand reports.

 

Perhaps someone can explain a feature of Duthie’s 1943 Review of English Studies article It is not a period piece Rather, they are in short supply Sentences are signaled by spaces and capitals only  Why is this? I can’t believe dots were rationed during the war Interestingly, ‘full stops’ are retained in quotations.

 

Gerald E Downs

 

 

 

 


          Het grote Fiat topic      Cache   Translate Page      
Replies: 1645 Last poster: Lampuhkap at 10-10-2018 00:34 Topic is Open M3rcury schreef op dinsdag 9 oktober 2018 @ 23:05: [...] Dat verbruik valt me best tegen. Het is toch een 2 cylinder? Had wel verwacht dat die 1:20 deden...Fabriek doen ze 1:24 maar dat haal je niet tenzij je heel enthousiast gaat hypermilen
          アレルライトハイパー(乳酸菌サプリ) 初回¥980円! 激安について      Cache   Translate Page      
アレルライトハイパーのご紹介です

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          [ASAP] Using the Negative Hyperconjugation Effect of Pentafluorosulfanyl Acceptors to Enhance Two-Photon Absorption in Push–Pull Chromophores      Cache   Translate Page      

TOC Graphic

Chemistry of Materials
DOI: 10.1021/acs.chemmater.8b02723

          Why hyper-converged gear needs to go the extra file: Merging blocks and filers to break out of the niche      Cache   Translate Page      

And how might this be done?

Backgrounder Hyper-converged infrastructure (HCI) is a popular way of dealing with complex server, SAN storage, and virtualization requirements with integrated, scale-out nodes that converge server compute, storage, and hypervisor technology in all-in-one clusterable elements.…


          Officials: Passenger dead after medical emergency on Delta jet      Cache   Translate Page      
The passenger, 62-year-old Yury Rubel, died of hypertensive cardiovascular disease; the plane returned to Detroit.
          Hyper centre, fac et plage      Cache   Translate Page      

Appartement hyper centre à 2 min de lavenue principale, du tramway et de toutes commodités. Tout équipé et situé à quelques arrêts des facs et universités grâce au tramway, lappartement est également proche des gares ( thiers et sud ) pour...
Sun, 09 Sep 2018 16:56:13 +0200
          Comments: Kalapea Garage: кастом Ducati Hyperscrambler      Cache   Translate Page      
Пффф, это разве кофры??? Вот это кофры! Вот это кастомайзинг!


          Comments: Kalapea Garage: кастом Ducati Hyperscrambler      Cache   Translate Page      
Хм… красиво?
          Hypercentre belle chambre 22m2 meublée      Cache   Translate Page      

Dans un bel appartement de 100m2, belle chambre de 22 m2 avec balcon, équipée avec un petit frigidaire, four micro onde, cafetière et grande TV …\r\nWC privatif, partage de la salle de bain et de la grande cuisine de 16 m2\r\nProche de toutes...
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          Comments: Kalapea Garage: кастом Ducati Hyperscrambler      Cache   Translate Page      
Спасибо! Получил эстетическое удовольствие!
          Application of Blood Pressure Guidelines Ups Treatment      Cache   Translate Page      
TUESDAY, Oct. 9, 2018 -- Implementation of the 2017 American College of Cardiology/American Heart Association (ACC/AHA) blood pressure guideline would direct initiation and intensification of antihypertensive medication treatment to adults at high... (Source: Drugs.com - Pharma News)
          Location Appartement 2 pièces      Cache   Translate Page      

IAD France - Jean Philippe GITTON (06 77 ##### ) vous propose: MERCI DE PRENDRE CONTACT UNIQUEMENT PAR MAIL DANS UN 1ER TEMPS.Meaux hyper-centre, 6 rue Louis Geoffroy, 5 mn gare à pieds.Appt de type F2 de 24 m² environ en duplex inversé et en...
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          Church-based programs may help bring blood pressure down      Cache   Translate Page      
By Linda Carroll (Reuters Health) – Lifestyle interventions delivered in churches by community-based health care workers may help bring down blood pressure among African-Americans, a new study finds. Hypertensive church members who attended weekly sessions devoted to lifestyle modification achieved an average drop of more than 16 points in systolic blood pressure levels, researchers reported […]
          Steam Developer's Catastrophic Mistake Has A Sort-Of Happy Ending      Cache   Translate Page      

A little more than a week ago, Steam developer HyperReuts was at rock bottom. The studio had given out 10,000 free keys for its multiplayer arena space game Evolvation, only for scammers to snap up a chunk of them. In response, HyperReuts tried to delete the offending keys, but in the process, it accidentally zapped…

Read more...


          Roomies by Christina Lauren      Cache   Translate Page      



By normal standards I should not have liked Roomies.  But I did!  Why?

Things that put me off initially:

The blurb on the front cover said 'A hypersexy sophisticated romance…'  This does not describe the book well and when you look closely at it it actually blurb about another book.  In fact you are two thirds into the book before any sex occurs and then it isn't overdone or gratuitous.

The title – Roomies – really?
The blurb on the back cover gives away too much of the story and sounds like the plot for Green Card (but he's Irish not French).

Why did I like it:

It is well written and draws you in quickly.  I read it in gulps.

While the plot is a cliché – face it – marrying a relative stranger to help them get a green card and then falling in love is not extremely original.  The way the plot was developed was interesting and not over wrought.

Holland, the main female protagonist is a quirky klutz working out what she wants in life – and like many women she doesn't realise what her talents are.

The author is actually a writing duo Christina Hobbs and Lauren Billings.  I didn't realise this until after I had finished.  The whole book felt like one person wrote it so hats off to them.

Wikipedia says that this book is to be made into a film.  I think that will work well.
          Comentario en ¿Dónde leer manga Little Girl online en español? por Anónimo      Cache   Translate Page      
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          Comment on Owen Jones, Idiot by Andrew      Cache   Translate Page      
<blockquote>Hyperbole on stilts.</blockquote> To be fair, when it comes to the likes of Mr. Jones advertising his views then it certainly can damage the health of society. But I doubt he means himself and his fellow travellers. <blockquote>capitalism</blockquote> I admire the bravery of the man, and the other capitalist haters like him, that they're prepared to endure the hardships of life in a capitalist hell such as the UK when they could easily move to one of the many socialist utopias. For example, look at how enlightened the population of North Korea are. You don't see them queuing up just to buy the latest iPhone or video game.
          Ayuda Armar pc      Cache   Translate Page      
Os pido presupuesto para estos componentes, busco la mejor adaptación posible, relación calidad precio. Dispongo en mi casa de una placa Asus P8P67 B3 Revision, un disipador hyper 212 evo y una gráfica asus gtx 570. Pues creo que me haría falta: fuente de alimentación, memorias ram ddr3(8gb),...
          Offer - Dell PowerEdge R820 Server Limited supply for Rental & Sale Kochi - INDIA      Cache   Translate Page      
Flexible, scalable I/O and storage options with PCI-e 3.0 technology allow you to tailor your network throughput to match your application needs. These hyper-scalable features make the DELL POWEREDGE R820 RACK SERVER a perfect fit for computing, memory-intensive applications and expanding virtual environments. Product Highlights Processor: Intel® Xeon® processor E5-4600 v4 Memory : Up 2400MT/s DDR4, RDIMM, LRDIMM Hard Disk: Up to 16 x 2.5” SATA/SAS SSD, SAS HDD Contact Rental India Name – Chackravarthy (8754542653) Name – Anushree (8971423090) Visit Us: https://shop.rental-india.com/product/dell-poweredge-r820-rack-server-available-on-rental-sale/ Mail Us: enquiry@rental-india.com Mandaveli, Chennai-28.
          Diet rich in fried and processed foods linked to increased hypertension in black Americans      Cache   Translate Page      
New findings suggest that diet is a major contributor for the increased risk of hypertension in black compared to white Americans. The results, published in the Journal of the American Medical Association, are part of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study, which looks at the incidence of stroke in approximately 30,000 individuals. The study is funded by the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health.
          Lifestyle changes reduce the need for blood pressure medications      Cache   Translate Page      
Men and women with high blood pressure reduced the need for antihypertensive medications by making lifestyle changes. A 16-week program, focused on the DASH diet, weight management and exercise, resulted in the most dramatic declines in blood pressure.
          POWER RANGERS Hyperforce Joins Legacy Wars      Cache   Translate Page      

Hyperforce joins Power Rangers Legacy Wars. Jack D. Thomas is a Timeforce beat cop. He joins a rag tag group of kids from the Timeforce Academy to be come Power Rangers Hyperforce. Mentored by Jen Scotts and aided by Alpha 55, the Hyperforce Rangers travel through time to stop the evil Velchanos from recruiting the […]

The post POWER RANGERS Hyperforce Joins Legacy Wars appeared first on That Hashtag Show.


          Hallelujah, Black Folks! Jesus Can Lower Your Blood Pressure, Study Finds      Cache   Translate Page      
A study suggested that practicing religion can improve efforts to reduce hypertension in Black people.
          Commenti su Recensione: Amianto di 2nd hand laboratory equipment      Cache   Translate Page      
<strong>2nd hand laboratory equipment...</strong> [...]that would be the end of this post. Right here you will find some web-sites that we consider you will value, just click the hyperlinks over[...]...
          Comment on Alleghany County Sheriff’s Office and Regional Jail badge by Business & Finance      Cache   Translate Page      
Thank you a lot for sharing this with all people you really know what you're speaking about! Bookmarked. Kindly additionally visit my site =). We will have a hyperlink exchange agreement between us!
          3B Golden Lane, Morning Star Heights      Cache   Translate Page      
*Studio type & 1 CR W/ High Ceiling *2 Wide Windows & Well Ventilated Areas *W/ Own Electric & Water meter *W/ Fire exit & Nearby fire extinguisher *W/ built in Cabinets *W/ Granite sink table *W/ tiled restroom & w/ shower & sink *Near to major malls *Near to known universities and colleges *Near to different dry & wet markets *Near to well known groceries, hypermarket, convenient & sari-sari ..
          Thinking outside the box: Adults with ADHD not constrained in creativity      Cache   Translate Page      
(University of Michigan) People often believe those with Attention Deficit Hyperactivity Disorder face challenges that could hinder future employment, but a University of Michigan study found that adults with ADHD feel empowered doing creative tasks that could help them on the job. (Source: EurekAlert! - Social and Behavioral Science)

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          Urban Inuit communities suffer from poor health and limited access to healthcare      Cache   Translate Page      
(Springer) Cases of cancer and hypertension are much higher among Inuit living in and around Ottawa than for the general population of Canada's capital city. This is according to a study co-led by Janet Smylie of St. Michael's Hospital and the University of Toronto in Canada and published in the Springer-branded Canadian Journal of Public Health. (Source: EurekAlert! - Social and Behavioral Science)
          HyperX Savage Exo刀锋移动固态硬盘评测:让玩家的游戏移动起来      Cache   Translate Page      
移动硬盘早已经在市场上普及了,但是它们大部分都是作为一些文档数据的迁移和存储,更多的是倾向于商务人士。而现在即使是没有工作需求的游戏玩家,也可以使用一款移动硬盘让自己的游戏能够在不同的电脑上转移。这就是HyperX Savage Exo刀锋移动固态硬盘。
          Microsoftの月例更新プログラム公開、IEやWindowsに深刻な脆弱性      Cache   Translate Page      
IEやEdge、Windows Hyper-Vの脆弱性など12件が「緊急」に指定されている。
          Be Fully Informed About Earthquakes      Cache   Translate Page      

Wazzup Pilipinas!

It's a grim reality: tremors of magnitude no less than 2.0 happen each day all over the world. A considerable lot of these are not by any means recognizable. The core of our planet is indeed hyper-active.

Big scale quakes of magnitude 7.0 and more happen at least once a month.The number of big-scale earthquakes has been on a steady rise.

How do Earthquakes Occur?
It happens when there is movement in the earth’s crust. When the tectonic plates collide or diverge along a fault line, explosive energy is released causing tremors that reach the earth’s surface.

Can an Earthquake Be Predicted?
At the moment no scientific calculations or machine intelligence can pinpoint the time and date that an earthquake can strike. Scientists can only make theoretical predictions of ‘where’ and ‘how’ by analyzing past data.

What Makes Earthquakes Dangerous?
It is the fact that we are always caught unawares. But again, the damage and injuries from the fall of buildings and collapse of infrastructure add to the danger. Earthquakes cause gas leaks, fires, and landslides. Victims can also catch infectious diseases when sewers burst open and fresh water is contaminated.

Tips to Stay Safe during an Earthquake
Don’t expect an evacuation call before an earthquake strikes. If you live in a region where tremors occur frequently, you should always stay ready.

When the tremor hits, get down fast and get cover. Hold on to something sturdy as you stay under a table or bed. That will help to protect you from falling debris.

Don’t be tempted to run outside– it is much worse out there where buildings may fall on you. Don’t stand in the doorway either. You might get thrown out by the force of the tremor. Also, a preparation measure would be to bolster your doors and secure your beds and tables with fasteners. That is if you live in parts of the world that directly sit on fault lines. These include Tokyo, Los Angeles, Jakarta, and Manila among others.

Significant earthquakes in the last decade
The biggest shocks in the past decade include the 7.9 magnitude quake of Sichuan Province in China, 2008. 87,000 people perished. A 7.5 magnitude shake in 2008 also hit Sumatra in Indonesia. However, the Haiti quake of 2010, with a 7.0 magnitude was more disastrous, taking with it 300,000 lives.

Christchurch in New Zealand saw its share of peril when a magnitude 6.3 hit in 2011. In the same year, North Eastern Japan sustained a hit from 9.0 magnitude earthquake. 2013 was Pakistani where magnitude 7.7 shake claimed 828 lives in Baluchistan province.
700 people lost their life in China 2014 when a 6.2 magnitude struck Yunnan province. In 2015 the same disaster struck in Nepal, affecting 8 million lives. The tremor started an avalanche from Mt Everest that claimed at least a dozen lives.
In 2016, Ecuador got hit with a 7.8 magnitude quake. In the same year, a magnitude 6.3 claimed 300 lives in Rome. In 2017, Central Mexico suffered a magnitude 7.1 quake that claimed 300 lives.

How to get involved to help victims?
Work with UNICEF or Red Cross either as a donor or volunteer. This is an organization that helps in emergency responses. They provide water, food, sanitation and medical aid to victims of catastrophes.

You can also donate blood.
You never know where or when earthquakes happen. Today is them tomorrow if it could be us. Stay safe, and lend a hand when humanity calls upon you.

          The Woman Who Fell to Earth - Press Reviews      Cache   Translate Page      
The Woman Who Fell to Earth: The Doctor (Jodie Whittaker) (Credit: BBC/BBC Worldwide (Sophie Mutevilian ))Press reaction to the new season of Doctor Who is overwhelmingly positive with Jodie Whittaker winning many plaudits for her first full episode as the Thirteenth Doctor

The Independent led the praise for the lead actress's performance. " After all the hype, hyperbole and inevitable internet hate, she acquits herself wonderfully in her full-length debut. Whittaker is a force of breezy nature – rambunctious, quirky but with a reassuringly familiar aura of Gallifreyan uncanniness."

The Guardian loved the interaction between the main characters. "The new Doctor and her team – 19-year-old Ryan, his old schoolmate turned police probationer Yasmin, and Ryan’s step-grandfather Graham (Tosin Cole, Mandip Gill and Bradley Walsh respectively) – have heart and soul, and are set against a comforting background of West Yorkshire women – especially Ryan’s nan – talking common sense as alien life and electrical pulses erupt around them."

Whittaker was also praised by the Telegraph who said the actress shined in a flawed but fun Doctor Who debut. "There has been a depressingly predictable knee-jerk backlash to a time-travelling, body-regenerating extraterrestrial with two hearts having the temerity to be female but this debut adventure barrelled straight past such quibbles. After mere minutes of the Doctor’s arrival – crashing through the roof of a train in Sheffield, having fallen from the Tardis at the climax of the Christmas special – you stopped noticing"

Digital Spy was sure Jodie Whittaker's Doctor is going to be everybody's new hero, and noted how her sex is irrelevant. "For all the buzz, positive and negative, that surrounded Whittaker's casting as the first female Doctor, what her first few scenes make abundantly clear is how unimportant the character's gender really is. It's completely and utterly incidental, a point which 'The Woman Who Fell to Earth' makes not through words – the transition from old to new is discussed no more here than it has been in previous Doctor's debuts – but through actions."

Den of Geek says series 11 premiere finds Doctor Who in rude health. "Whittaker certainly makes an impact in her opening scene - quite literally, as she falls through the roof of the train and meets her new companions. The script cleverly wastes no time in having her do some proper ‘Doctor business’ - fending off an alien, casually dismissing a death in favour of the mystery at hand and persuading police officer Yas not to call for reinforcements. Whittaker shines pretty quickly in these scenes, and has every bit of the quiet intensity of her predecessors."

Variety felt the episode fulfilled a difficult brief. "Striking the right balance has been a tall order for any new Doctor and showrunner to take on, as several pairs have done over the last decade, but the level of difficulty this particular team had to master is arguably the highest yet. That’s why it’s so impressive that “The Woman Who Fell to Earth” is, for the most part, an extremely typical episode of “Doctor Who."

NPR loved the characterisation of The Doctor "With her rich Northern accent (the actress was born in Yorkshire), Whittaker's Doctor isn't posh or effete — no bow ties or fezzes for her. Instead, she radiates pragmatism (if pragmatism is a thing that can radiate) and a decidedly middle-class, we're-all-in-this-together enthusiasm."

Finally, the Los Angeles Times says Doctor Who returns in thrilling fashion. "The new Doctor has both authority and energy; she is playful yet mature, a little mad but not manic, funny and agile and perhaps will turn out a shade less judgmental than some of her predecessors. Chibnall has given Whittaker a lighter brief: “I’m the Doctor,” she declares, “sorting out fair play throughout the universe.” And later, in that soft Yorkshire accent, “Sometimes I see things that need fixin’ and do what I can.”

The Doctor Who News review can be found on our reviews site.
          Sunday Reads      Cache   Translate Page      
Noted opera singer Montserrat Caballe, 85, passed away yesterday.  She was one of the most renowned singers in her field in the twentieth century.

For sheer vocal glory, reviewers wrote, few voices, if any, could rival Ms. Caballé’s. She was possessed of a lyric soprano that, though light and shimmering, was not without heft. It was renowned for its riverine suppleness, and for an ethereal translucence that few other voices could equal.

Over nearly half a century, critics invoked adjectives to describe Ms. Caballé’s sound that would read as staggering hyperbole for almost anyone else: “limpid,” “liquid,” “shimmering,” “quicksilver,” “celestial,” “unearthly,” “velvety,” “voluptuous,” “lustrous,” “ravishing.”

“She possesses,” Stereo Review magazine said of Ms. Caballé in 1992, “one of the most beautiful voices ever to issue from a human throat.”

In other words, she was a larger than life figure.
_____

One idiot Democrat and a slew of GOP idiots confirmed drunk and rapist Brett Kavanaugh, but that hasn't stopped people from protesting the appointment.
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This was horrific beyond description:



Twenty people were killed including many, many members of one family.
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          Hypertough lawn mower      Cache   Translate Page      
Hypertough 20 inch side discharge lawn mower. Never been used. $175.00
          Unable to see device in NI MAX when it shows in Windows Device Manager      Cache   Translate Page      

I have two new workstations that I'm interfacing with some KD Legato 100 Syringe pumps. My goal is to give the two devices aliases for use in my LabVIEW application (which is built into an executable). The drivers for these pumps are installed correctly, and I can interface with them just fine over HyperTerm, and they have valid COM ports. I've done the following:

 

1) Power cycle everything

2) Reset the MAX database (on both machines, no dice)

3) Reinstall MAX (on both machines)

 

I can't even see the unaliased COM ports on these machines in the application. Any ideas?


          Google House Hub Is A Photograph-Centric Google Assistant With A Display      Cache   Translate Page      

The voice-activated gadget will body all of your greatest footage, play YouTube movies, and present reside footage out of your related safety cam. And it solutions questions too. View Complete Publish › Supply hyperlink
          Reply Six Questions And We'll Inform You What You And Your Buddies Ought to Be For Halloween      Cache   Translate Page      

Selecting your Halloween costume is half the battle. View Whole Submit › Supply hyperlink
          It’s alive! Scientists create ‘synthetic life’ on a quantum pc      Cache   Translate Page      

No, this is not one thing from a Michael Crichton techno-thriller: Scientists actually have created “synthetic life” on a quantum pc for the primary time ever. This is why that issues. The publish It’s alive! Scientists create ‘synthetic life’ on a quantum pc appeared first on Digital Developments. Supply hyperlink
          Comment on Infestation: Staple Day 2 by Superior Singing Method      Cache   Translate Page      
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          Comment on ScreamCast 63: J.R. Bookwalter VS The Demons, Scarecrows and Dead Next Door by Superior Singing Method      Cache   Translate Page      
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          Sales Director      Cache   Translate Page      
CA-San Jose, Company Information: Quanta Cloud Technology (QCT, LLC) is a global datacenter solution provider. We combine the efficiency of hyperscale hardware with infrastructure software from a diversity of industry leaders to solve next-generation datacenter design and operation challenges. QCT serves cloud service providers, telecoms and enterprises running public, hybrid and private clouds. Product lines
          Now-paralysed student went from 'hyper to blank' after police 'pounced' misconduct hearing told      Cache   Translate Page      
Four officers are accused of failing to conduct any welfare checks.
          Lumitron unveils laser-based x-ray system      Cache   Translate Page      

X-ray technology developer Lumitron Technologies has unveiled HyperView, a...



          mHealth Integrated Model of Hypertension, Diabetes and Antenatal Care in India and Nepal      Cache   Translate Page      
Conditions:   Gestational Diabetes;   PIH Pregnancy Induced Hypertension
Intervention:   Other: mHealth Integrate Model of Antenatal Care
Sponsors:   Public Health Foundation of India;   London School of Hygiene and Tropical Medicine;   Kathmandu University School of Medical Sciences
Not yet recruiting
          The Effect of Cold Exposure on Glucose Tolerance      Cache   Translate Page      
Condition:   Hyperglycemia
Intervention:   Other: Temperature
Sponsor:   Maastricht University
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          Hypertension Management Using Telemonitoring      Cache   Translate Page      
Condition:   Hypertension
Intervention:   Other: Remote Telemonitoring
Sponsor:   University of Mississippi Medical Center
Recruiting
          A Calvin Klein fez os jeans coloridos que nós queremos usar no verão!      Cache   Translate Page      
HyperFocal: 0 (Foto: Divulgação)

 

Inspirado no cenário e na cultura americana, Raf Simons acaba de lançar a coleção de verão 2019 da Calvin Klein. O resultado é uma mistura de pop e utilitário e nós estamos apaixonadas!

+ Fluvia Lacerda divide dicas de styling com jeans plus size
+ Meghan Markle encontrou o vestido jeans perfeito (e ele é by Carolina Herrera)
+ Calvin Klein divulga 2ª parte de campanha com as Kardashians Jenners

Personagens icônicos da cultura americana como os cowboys, as cheerleaders e os operários das grandes metrópoles foram referência para peças repaginadas nesta temporada. Aqui no Brasil, o denim ganha destaque em duas versões: multicolorido ou com aplicações de recortes em diferentes lavagens, das mais escuras ao branco -- e são tudo o que mais queremos usar já. Dá uma olhada nos cliques abaixo. Um show!

HyperFocal: 0 (Foto: Divulgação)
HyperFocal: 0 (Foto: Divulgação)
HyperFocal: 0 (Foto: Divulgação)
HyperFocal: 0 (Foto: Divulgação)
HyperFocal: 0 (Foto: Divulgação)
HyperFocal: 0 (Foto: Divulgação)

 

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          Increase Your Focus and Combat Distractions      Cache   Translate Page      

Guest Chris Bailey, author of Hyperfocus, discusses what drives us to distraction in our tech-saturated world, and what we can do to combat those forces and gain greater focus.


          Location Appartement 2 pièces      Cache   Translate Page      

IAD France - Jean Philippe GITTON (06 77 ##### ) vous propose: MERCI DE PRENDRE CONTACT UNIQUEMENT PAR MAIL DANS UN 1ER TEMPS.Meaux hyper-centre, 6 rue Louis Geoffroy, 5 mn gare à pieds.Appt de type F2 de 24 m² environ en duplex inversé et en...
2 pièces 24 m² duplex
Mon, 08 Oct 2018 17:27:55 +0200
          Neurocrine Biosciences and Jnana Therapeutics Enter Strategic Collaboration to Discover Novel Medicines to Treat Central Nervous System Disorders      Cache   Translate Page      
...valbenazine for the treatment of Tourette syndrome, and NBI-74788 for the treatment of congenital adrenal hyperplasia (CAH). For more information and the latest updates from Neurocrine Biosciences, please visit www.neurocrine.com . About Jnana Therapeutics Inc. Jnana Therapeutics is a ...

          Rural Servicios Informáticos to Manage Complete 'Data Lifecycles' with Commvault HyperScale™ Technology      Cache   Translate Page      
...helps them to Picture the Possibilities of how effective data management addresses their ever-changing data and business needs. More information can be found here: https://www.commvault.com/go/agenda . Take part in and engage with the online conversation across ...

          Comentario en WOD 8 Oct PERFORMANCE por sorte strømper      Cache   Translate Page      
<strong>sorte strømper</strong> [...]here are some hyperlinks to web sites that we link to for the reason that we think they are worth visiting[...]
          Awesome Mails Pro 3.19.1 – Create interactive emails.      Cache   Translate Page      
Awesome Mails Pro 2 (was Awesome Mails) is a professional newsletter and marketing email designer. Create beautiful interactive emails with photos, stylish fonts, and web hyperlinks. Features Tested compatible with all major email clients Supports full screen mode and retina display Supports additions of photos, formatted texts, and hyper links Create and save multiple To, […]
          Comment on Role of Size in Logo Design by 3D hole wall stickers      Cache   Translate Page      
here are some hyperlinks to web-sites that we link to mainly because we consider they may be worth visiting
          Hyperz [09-OCT-2018]      Cache   Translate Page      
Aluna George – I’m In Control (starjack Hype Re-drum)[clean] 104 (04:45) Baltimore – Tarzan Boy [80s Hype Redrum] – 115 Bpm (03:53) Bangles – Manic Monday [80s Hype Redrum] 121bpm (03:45) Bts Ft Nicki Minaj – Idol (club Breakerz Hype Edit) (clean) (03:41) Daddy Yankee – Shaky (starjack Hype Reggaeton Edit)[clean] 100 (04:18) Daddy Yankee … Continue reading Hyperz [09-OCT-2018]
          Muscle Spasm Market Analysis 2020, Major Key Players Reviews      Cache   Translate Page      

Albany, NY -- (SBWIRE) -- 10/09/2018 -- Muscle spasm is involuntary, sudden contraction of muscle or group of muscles of the body. Muscle spasm is also known as muscle cramp or involuntary hypertonicity. Muscle spasm usually occurs after muscular injury and is a sudden blast of high intensity pain, which ceases after five to ten minutes. Muscle spasm, in general condition, does not cause any chronic harm to the body. The most commonly affected muscles are lower leg muscles, front of the thigh and back of the thigh. Additionally, muscles of arms, feet, hands and abdomen are also affected, although the proportion is less.

Read Report Overview: https://www.transparencymarketresearch.com/muscle-spasm-market.html

The major causes of muscle spasm include muscular injury, spinal nerve compression, sprains and strains of the muscle (due to overuse) and diabetic ketoacidosis. Additionally, rickets, low blood potassium and sodium, animal instincts, and heat stroke are some of the other important causes of the condition. Since these cramps do not lead to any chronic condition, usually medical diagnosis and treatment is not advised. However, if the condition is persistent for longer period of time, a proper diagnosis is required. Blood test is a major diagnosis test (to understand thyroid functions, potassium and sodium levels) for muscle spasm. Additionally, electromyography is also performed to diagnose the disease.

The market of muscle spasm is segmented on the basis of drugs used to treat the condition, such as, diazepam, quinine, phenytoin, carbamazepine and others. Additionally, rehydration therapy, vitamin E, magnesium, calcium and niacin are also prescribed. The market is also segmented on the basis of geography, such as North America, Europe, Asia-Pacific and Rest of the World (RoW).

The North American region is the most dominating market in the world, owing to large incidences of muscle spasm, and rising focus towards R&D for muscle spasm treatments. On the other hand, Asia Pacific and RoW are the most promising markets in the upcoming period, owing to rise in awareness of muscle spasm, its causes and effects and its treatments.

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The market of muscle spasm is likely to show steady growth during the forecast period from 2014 to 2020. This growth is likely to support by the factors such as increased athlete activities and thereby increased threat of muscle spasm, R&D activities and growing awareness of muscle spasm. Large number of exercise associated with muscle spasms is considered as an important driver of this market. For instance, according to the study conducted by the American Medical Society for Sports Medicine, 67% of triatheletes were suffered from exercise-associated muscle cramps (EAMC). Out of this, 50% were runners, whereas 15% were bikers. Additionally, due to R&D, drug formulations such as URG101 and others are under pipeline studies and are expected to enter in the market during the forecast period from 2014 to 2020. These drivers are likely to support the growth of muscle spasm market. On the other hand, limited diagnosis, self-limiting nature of the disease and high cost of R&D are some of the restraints of the market. Since the disease is self-limiting (maximum duration of cramp is around 10 minutes), usually people do not take any medicines. These factors are expected to hamper the market growth during the analysis period from 2014 to 2020.

Some of the major players operating in this market include Amgen, Inc., Eisai Co., Ltd., Novartis International AG, GlaxoSmithKline plc, AstraZeneca plc, Pfizer, Inc., and F. Hoffmann La Roche Ltd. amongst others.

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About Transparency Market Research
Transparency Market Research (TMR) is a U.S.-based provider of syndicated research, customized research, and consulting services. TMR's global and regional market intelligence coverage includes industries such as pharmaceutical, chemicals and materials, technology and media, food and beverages, and consumer goods, among others. Each TMR research report provides clients with a 360-degree view of the market with statistical forecasts, competitive landscape, detailed segmentation, key trends, and strategic recommendations.

Contact us:
Transparency Market Research
90 State Street,
Suite 700,
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NY - 12207
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Tel: +1-518-618-1030
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For more information on this press release visit: http://www.sbwire.com/press-releases/muscle-spasm-market/release-1059953.htm

Media Relations Contact

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          Endocrine, Nutritional, & Metabolic Disorders Market Worldwide Major Trend Outlook 2014 to 2020      Cache   Translate Page      

Albany, NY -- (SBWIRE) -- 10/09/2018 -- Endocrine, Nutritional, & Metabolic Disorders include diseases that affect endocrine glands (thyroid, parathyroid, pituitary, adrenals, thymus, islets of pancreas, ovaries and testicles), nutritional deficiencies such as malnutrition and vitamin deficiencies, and metabolism disorders such related lipid metabolism, carbohydrate metabolism, amino acid metabolism, plasma protein metabolism and other metabolic disorders.

Read Report Overview: https://www.transparencymarketresearch.com/endocrine-nutritional-metabolic-disorders.html

Endocrine glands release specific hormones in the blood stream which help in coordinating and controlling several physiological processes in the body. An imbalance (increase, decrease or absence) in the release of these hormones results in an endocrine disorder or diseases such as diabetes, obesity, thyroid disorders, osteoporosis and hormone malfunction. The diseases related to endocrine disorders can be categorized as diseases of thyroid gland and diseases other endocrine glands. Thyroid gland disorders include goiter (simple goiter, non-toxic nodular goiter, toxic nodular goiter and thyrotoxicosis), cretinism, myxedema, and thyroiditis. Other endocrine gland disorder includes, diabetes mellitus, hypoglycemic coma, disorders of pituitary gland (acromegaly, gigantism and diabetes insipidus), disorders of thymus gland (persistent hyperplasia of thymus gland and abscess of thymus), and disorders of adrenal glands (Conn's syndrome, Addison's disease, phaecochromocytoma. Ovarian dysfunction is also due to endocrine disorders and includes, hyperestrogenism, polycystic ovaries, and Stein-Leventhal syndrome while the testicular dysfunction include Goldberg-Maxwell syndrome and testicular feminization. Treatment approached for the endocrine disorders are highly specific to the disease or disorder.

For instance, surgical removal of enlarged gland in case of hyperparathyroidism (HPT), hormonal replacement treatment for hypothyroidism (thyroxine), hypoadrenalism (hydrocortisone and fludrocortisone), hypopituitarism (vasopressin analogues such as desmopressin), hypoparathyroidism (treatment with calcium and either vitamin D or dihydrotachysterol).

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Nutritional disorders cause illness in humans and include deficiencies or excesses in the diet, eating disorders, obesity and other several chronic diseases related to cardiovascular system. These disorders also include preventable abnormalities and metabolic disorders. The nutritional deficiency disorders include disorders due to: vitamin A deficiency (night blindness, xerophthalmia, and keratomalacia), thiamine deficiency (endemic neuritis and beriberi), vitamin B deficiency (ariboflavinosis and pellagra), ascorbic acid deficiency (Barlow's disease, infantile scurvy), vitamin D deficiency (rickets and osteomalacia) and vitamin E deficiency disorders.

Other nutritional disorders include disorders due to deficiency of vitamin K and other unspecified vitamin deficiency. Nutritional disorders are treated on case basis depending on the type of disorder but treatments options often include use of drugs such as antibiotics and steroids, and surgical interventions if required.

Metabolism is a process through which process body breakdown food parts into sugars and acids. During metabolic disorder, this process is disrupted and leads to excess of scarcity of essential substances which help individual to stay healthy. These disorders are either inherited or are acquired during the lifetime of a person. Phenylketonuria is an example of inherited metabolic disorder in which the body is unable to breakdown amino acid phenylalanine. Other prominent metabolic disorders include type 1 diabetes, Gaucher's disease, maple syrup urine disease, cystinosis, Fabry disease, Hartnup disease, Hunter syndrome, Hurler syndrome, von Gierke disease and hereditary hemochromatosis. Metabolic disorders are treated by normalizing the metabolic balance by reversing the cause of disorder and administering medication for continuing the proper metabolic function.

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Multimodal treatment is generally adopted for treating metabolic disorders which might include mineral supplementation, vitamin supplementation, bone marrow supplementation, physical therapy, specific surgical interventions and medications for reducing the symptoms of metabolic disorders.

About Transparency Market Research
Transparency Market Research (TMR) is a U.S.-based provider of syndicated research, customized research, and consulting services. TMR's global and regional market intelligence coverage includes industries such as pharmaceutical, chemicals and materials, technology and media, food and beverages, and consumer goods, among others. Each TMR research report provides clients with a 360-degree view of the market with statistical forecasts, competitive landscape, detailed segmentation, key trends, and strategic recommendations.

Contact us:
Transparency Market Research
90 State Street,
Suite 700,
Albany
NY - 12207
United States
Tel: +1-518-618-1030
USA - Canada Toll Free 866-552-3453
Email: sales@transparencymarketresearch.com
Website: http://www.transparencymarketresearch.com/

For more information on this press release visit: http://www.sbwire.com/press-releases/endocrine-nutritional-amp/release-1059952.htm

Media Relations Contact

Rohit Bhisey
AVP Marketing
Telephone: 1-518-618-1030
Email: Click to Email Rohit Bhisey
Web: https://www.transparencymarketresearch.com/de-ionized-pineapple-concentrate-market.html

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          微软发布10月补丁修复51个安全问题      Cache   Translate Page      
微软于周二发布了10月安全更新补丁,修复了51个从简单的欺骗攻击到远程执行代码的安全问题,产品涉及.NET Core、Azure、Device Guard、Internet Explorer、Microsoft Edge、Microsoft Exchange Server、Microsoft Graphics Component、Microsoft JET Database Engine、Microsoft Office、Microsoft Office SharePoint、Microsoft Scripting Engine、Microsoft Windows、Microsoft Windows DNS、Microsoft XML Core Services、SQL Server、Windows - Linux、Windows Hyper-V、Windows Kernel、Windows Media Player以及Windows Shell。
          Comment on Creature seed: Octo𝜋. by Rockphed      Cache   Translate Page      
I have to agree with your wife: pi in an 8 dimensional space is still pi. No, what gets weird is the surface area of an 8-dimensional hyper-sphere. Not least because the "surface" of an 8-dimensional hyper-sphere is a 7-dimensional space, and thus has volume in more than twice the dimensions of a regular sphere.
          競合のブロックチェーン業界団体「EEAとHyperledger」が連携ーービジネスシーンでの活用を加速へ      Cache   Translate Page      

本稿は11月18日から20日まで東京ミッドタウン日比谷で開催されるブロックチェーンカンファレンス「NodeTokyo 2018」編集部による寄稿 ピッ...

投稿 競合のブロックチェーン業界団体「EEAとHyperledger」が連携ーービジネスシーンでの活用を加速へTHE BRIDGE(ザ・ブリッジ) に最初に表示されました。


          Orbitomaxillofacial Mucormycosis Requiring Complex Multifactorial Management      Cache   Translate Page      
Summary: Mucormycosis is a rare fungal infection caused by ubiquitous fungi in the order Mucorales. It is the most rapidly progressing fulminant fungal infection that mimics necrotizing soft-tissue infections. Overwhelming fungal sepsis develops quickly and mortality rates approach 70%. Culture negative necrotizing infections and cutaneous necrosis following a vascular pattern should raise suspicion for this rare entity. We describe avoiding mortality in a case of orbitomaxillofacial mucormycosis multifactorially treated with: radical serial debridement, topical amphotericin B irrigation and dressings, parenteral amphotericin B, and hyperbaric oxygen therapy. Tissue biopsy was central to confirming the diagnosis and directing multimodal management that ultimately prevented dissemination to the central nervous system and mortality. This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Published online 2 October 2018. Received for publication May 6, 2018; accepted July 11, 2018. Disclosure: The authors have no financial interest to declare in relation to the content of this article. The Article Processing Charge was paid for by the authors. Jevon Y. Brown, MSc, FRCSC, Section of Plastic Surgery, Department of Plastic Surgery, University of Calgary, 200–2004 14th Street NW, Calgary, AB T2M 3N3, E-mail: Jevon.Brown2@albertahealthservices.ca Copyright © 2018 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the American Society of Plastic Surgeons. All rights reserved.
          Jedidah Isler #ALD18 @findingada      Cache   Translate Page      
Jedidah Isler is an Astrophycist and was the first African American woman to earn a PhD from Yale in astrophysics. In addition to studying “hyperactive, supermassive black holes” Isler advocates for inclusivity in STEM. Via TED: Jedidah Isler has been staring at the stars since she was 11 or 12. But because neither her undergraduate […]
          Microsoftの月例更新プログラム公開、IEやWindowsに深刻な脆弱性      Cache   Translate Page      
IEやEdge、Windows Hyper-Vの脆弱性など12件が「緊急」に指定されている。
          ASUS ZenBook Flip S UX370UA-C4211T laptop Intel Quad Core i7-8550U, 4.00GHz-es processzorral, 8GB - Jelenlegi ára: 476 900 Ft      Cache   Translate Page      
EgyébSúly1. 1 kgKialakításTermék színeSzürkeKülső megjelenésÁtalakítható (sátor)Termék típusaHibrid (2 az 1-ben)Tömeg és méretekTömeg1, 1 kgSzélesség31, 3 cmMélység21, 8 cmMagasság1, 09 cmSzín-Csatlakozók és csatlakozási felületekKombinált fejhallgató/mikrofon port✔ USB 3. 0 (3. 1 Gen 1) C típusú portok száma2 AdattárolásTeljes tárolókapacitás512 GBAdathordozóSSDTelepített SSD-k száma1 SSD meghajtó kapacitása512 GBSSD meghajtó csatlakozófelületeSerial ATA IIIFényképezőgépElülső kamera✔ Speciális processzor funkciókIntel? Identity Protection Technology (Intel? IPT)✔ Intel Hyper-Threading Technology (Intel? HT Technology)✔ Intel? Turbo Boost Technology2 Enhanced Intel? SpeedStep Technology✔ Intel? Clear Video HD Technology (Intel? CVT HD)✔ Intel? Clear Video Technology✔ Intel? InTru? 3D Technology✔ Intel? Quick Sync Video Technology✔ Intel? AES New Instructions (Intel? AES-NI)✔ Intel? Enhanced Halt State✔ Intel? VT-x with Extended Page Tables (EPT)✔ Intel? OS Guard✔ Intel? Clear Video technológia mobil internet eszközökhöz (Intel CVT for MID)✔ Intel? 64✔ Execute Disable Bit✔ Hőfigyelő technológiák✔ A processzor csomag mérete42 x 24CPU konfiguráció (max. )1 Intel? Virtualization Technology for Directed I/O (VT-d)✔ Intel? Virtualization Technology (VT-x)✔ Processzor ARK ID122589 Intel? TSX-NI✔ Intel? Software Guard Extensions (Intel? SGX)✔ Intel? My WiFi Technology (Intel? MWT)✔ Intel? Flex Memory Access✔ Tétlen állapotok✔ Támogatott parancskészletekAVX 2. 0 / SSE4. 1 / SSE4. 2VideokátyaVideókártya típusaIntegráltVideókártya márkaIntelVideókártya memória típusaDDR3Csatlakozás & PortokPortok2 x USB 2. 0Wireless802, 11 acBluetooth verzió4, 1 Általános jellemzőkBillentyűzet nyelvMagyar billentyűzetAkkumulátor élettartam2 hProcesszorProcesszormodelli7-8550UProcesszormagok száma4 Cache8192 kBProcesszorgyártóIntel? ArchitektúraKaby LakeAlap frekvencia1, 8 GHzTurbo Boost frekvencia4 GHzL2-gyorsítótár8Processzor típusai7MemóriaMemória maximális sebessége1, 866 GHzMemória típusaDDR3Frekvencia1, 866 GHzMemória kapacitás8 GBSlotok száma1 Elfoglalt slotok1 Memória mérete8 GBKijelzőKijelző felbontása1920Érintőképernyő✔ Képernyőátló13, 300000000017 ? Kijelző átmérő33, 782000034458 cmKijelző technológiaLEDKijelző felületFényesFelbontás1920 x 1080Kijelző felbontásFull HDKépernyőÁtlós képernyő33, 8 cmKépernyőfelbontás1920 x 1080 pixelekHD típusaFull HDMéretarány16 : 9Érintőképernyő✔ LED háttérvilágítás✔ VideokártyaVideokártya típusaIntegráltOptikai meghajtóOptikai meghajtóMeghajtó nélkülMerevlemezMerevlemez kapacitása512 GBTárhely típusaSSDTárolókapacitás512 GBOperációs rendszerOperációs rendszerMicrosoft Windows 10 Home 64bitSzoftverTelepített operációs rendszerWindows 10 HomeMultimédiaWebkameraHDHangBeépített mikrofon✔ HangrendszerSonicMaster PremiumErgonómia / FormatervezésKijelző típusa13, 3" FULL HD LED / fényesAkkumulátorAkkumulátor-technológiaLítium-polimer (LiPo)Akkumulátorcellák száma2 Akkumulátor maximális élettartama11, 5 óAkkumulátor kapacitása (wattóra)39 WhHálózatBluetooth verzió4. 1BluetoothVanWi-Fi szabványokIEEE 802. 11acWi-Fi✔ AdatátvitelAdatátvitelBluetooth / WlanTápellátásAkkumulátor cellaszáma2 AC adapter eloszlás45 WAC adapter frekvenciája50 / 60 HzAC adapter bemeneti feszültsége100 ? 240 VAC adapter kimeneti feszültsége19 GrafikaBeépített grafikus adapter✔ Diszkrét grafikus adapter-modellNem áll rendelkezésreFedélzeti grafikus adapter azonosítója0 x 5917Fedélzeti grafikus adapter DirectX verzió12 Fedélzeti grafikus adapter OpenGL verzió4, 4 Fedélzeti grafikus adapter-modellIntel UHD Graphics 620A fedélzeti grafikus adapter alapfrekvenciája300 MhzMaximális fedélzeti grafikus adapter memória32 GBA támogatott kijelzők száma (fedélzeti grafika)3 A fedélzeti grafikus adapter dinamikus frekvenciája (max. )1150 MhzAlaplapProcesszorfoglalatBGA 1356Méretek és súlySúly1. 1 kgBillentyűzetWindows-gombok✔ MutatóeszközÉrintőpadBiztonságUjjlenyomat-olvasó✔
ASUS ZenBook Flip S UX370UA-C4211T laptop Intel Quad Core i7-8550U, 4.00GHz-es processzorral, 8GB
Jelenlegi ára: 476 900 Ft
Az aukció vége: 2018-10-10 06:07
          LENOVO IDEAPAD 320 80XJ000UHV laptop Intel Dual Core i3-6006U, 2.00GHz-es processzorral, 17.3" HD+ - Jelenlegi ára: 186 900 Ft      Cache   Translate Page      
Általános jellemzőkNumerikus billentyűzet✔ Billentyűzet nyelvMagyar billentyűzetAkkumulátor élettartam2 hEgyébSúly2. 8 kgKialakításTermék színeFeketeKülső megjelenésVédőtokTermék típusaNotebookKészülékház anyagaAkrilnitril-butadiénsztirol (ABS) / PolikarbonátSzín elnevezéseOnyx blackTömeg és méretekTömeg2, 8 kgSzélesség41, 8 cmMélység29, 26 cmMagasság2, 49 cmSzínfeketeCsatlakozók és csatlakozási felületekHDMI portok mennyisége1 USB 3. 0 (3. 1 Gen 1) A típusú portok száma2 Kombinált fejhallgató/mikrofon port✔ DC-bemeneti jackdugó✔ USB 3. 0 (3. 1 Gen 1) C típusú portok száma1 HDMI-verzió1, 4 AdattárolásTeljes tárolókapacitás1000 GBAdathordozóHDDBeépített kártyaolvasó✔ Telepített merevlemezek száma1 Merevlemez csatolófelületSATA IIIKompatibilis memóriakártyákMMC / SD / SDHC / SDXCFényképezőgépElülső kamera✔ Speciális processzor funkciókIntel? Wireless Display (Intel? WiDi)✔ Intel? Smart Response Technology✔ Intel Hyper-Threading Technology (Intel? HT Technology)✔ Intel? Small Business Advantage (Intel? SBA)✔ Enhanced Intel? SpeedStep Technology✔ Intel? Clear Video HD Technology (Intel? CVT HD)✔ Intel? Clear Video Technology✔ Intel? InTru? 3D Technology✔ Intel? Quick Sync Video Technology✔ Intel? AES New Instructions (Intel? AES-NI)✔ Intel? Enhanced Halt State✔ Intel? VT-x with Extended Page Tables (EPT)✔ Intel? Secure Key✔ Intel? OS Guard✔ Intel? Clear Video technológia mobil internet eszközökhöz (Intel CVT for MID)✔ Intel? 64✔ Execute Disable Bit✔ Hőfigyelő technológiák✔ A processzor csomag mérete42 x 24CPU konfiguráció (max. )1 Intel? Virtualization Technology for Directed I/O (VT-d)✔ Intel? Virtualization Technology (VT-x)✔ Processzor ARK ID91157 Intel? Software Guard Extensions (Intel? SGX)✔ Intel? My WiFi Technology (Intel? MWT)✔ Intel? Flex Memory Access✔ Tétlen állapotok✔ Támogatott parancskészletekAVX 2. 0 / SSE4. 1 / SSE4. 2ProcesszorkódSSSR2UWAudióHangszóró teljesítménye1, 5 WVideokátyaVideókártya típusaDedikáltVideókártya márkanVidiaVideókártya memória kapacitás2 GBVideókártya memória típusaGDDR5Csatlakozás & PortokPortok1 / 2 / 1 / 1 / 45KártyaolvasóSDWireless802, 11 ac/a/b/g/nHálózat10 / 100 / 1000Bluetooth verzió4, 1 ProcesszorProcesszormodelli3-6006UProcesszormagok száma2 LéptetőD1Tjunction100 °CThermal Design Power (TDP)15 WCache3072 kBA processzor frekvenciája2 GHzProcesszormagok2 Processzorszálak4 A buszrendszer sebessége4 GT/másodpercProcesszor gyorsítótár3 MBA processzor gyorsítótárának típusaSmart CacheProcesszor litográfia14 nmProcesszor üzemmódok64 -bitA processzor kódneveSkylakeProcesszor sorozatIntel Core i3-6000 Mobile Processor SeriesProcesszorgyártóIntel? A PCI Expressz sávok maximális száma12 PCI-expressz csatlakozók verziója3 PCI Express konfigurációk1Konfliktusmentes processzor✔ Busz típusaOPIArchitektúraKaby LakeAlap frekvencia2 GHzTurbo Boost frekvencia2 GHzProcessszorcsalád6. generációs Intel? Core? i3Processzor típusai3MemóriaMaximális belső memória16 GBBelső memória4 GBMemória típusaDDR4Frekvencia2, 133 GHzBelső memória típusaDDR4-SDRAMMaximális belső memória (64 bites)16 GBMemória kapacitás8 GBSlotok száma1 Elfoglalt slotok1 Memória órajel2133 MhzKépernyőÁtlós képernyő43, 9 cmKépernyőfelbontás1600 x 900 pixelekHD típusaHD+Méretarány16 : 9LED háttérvilágítás✔ KijelzőFényerő200 cd/m? Kijelző átmérő43, 942000044821 cmKijelző technológiaLEDKijelző felületMattFelbontás1600 x 900Kijelző felbontásHD+Optikai meghajtóOptikai meghajtó típusaDVD? RWMerevlemezMerevlemez kapacitása1000 GBFordulatszám5400 fordulat/percTárhely típusaHDDTárolókapacitás1000 GBMerevlemez mérete2, 5000000000091 ? Operációs rendszerOperációs rendszerMicrosoft Windows 10 Home 64bitSzoftverTelepített operációs rendszerWindows 10 HomeAz operációs rendszer architektúrája64 -bitTartozékokHálózati vezeték mellékelve✔ Felhasználói kézikönyv✔ AC adapter mellékelve✔ MultimédiaWebkameraHDOptikai egység✔ HangBeépített mikrofon✔ Beépített hangszórók száma2 HangrendszerDolby AudioAkkumulátorAkkumulátor-technológiaLítium-polimer (LiPo)Akkumulátorcellák száma2 TanúsítványokEnergy Star tanúsítvány✔ EPEAT megfelelésEzüstRoHS megfelelés✔ HálózatBluetooth verzió4. 1BluetoothVanWi-Fi szabványokIEEE 802. 11a / IEEE 802. 11ac / IEEE 802. 11b / IEEE 802. 11g / IEEE 802. 11nWi-Fi✔ LAN adatátviteli sebesség10 / 100 / 1000 Mbit/sEthernet/LAN csatlakozás✔ TápellátásAC adapter frekvenciája50 / 60 HzAC adapter bemeneti feszültsége100 ? 240 VGrafikaBeépített grafikus adapter✔ Diszkrét grafikus adapter-modellNVIDIA GeForce 920MXFedélzeti grafikus adapter azonosítója1916 Diszkrét grafikus adapter✔ Fedélzeti grafikus adapter DirectX verzió12 Fedélzeti grafikus adapter OpenGL verzió4, 4 Fedélzeti grafikus adapter-modellIntel? HD Graphics 520A fedélzeti grafikus adapter alapfrekvenciája300 MhzMaximális fedélzeti grafikus adapter memória32 GBA támogatott kijelzők száma (fedélzeti grafika)3 A fedélzeti grafikus adapter dinamikus frekvenciája (max. )900 MhzDiszkrét grafikus adapter memória2 GBDiszkrét grafikus memória típusaGDDR5AlaplapProcesszorfoglalatBGA 1356Méretek és súlySúly2. 8 kgBillentyűzetWindows-gombok✔ Numerikus billentyűzet✔ MutatóeszközÉrintőpadBiztonságJelszavas védelem típusaHDD / Bekapcsoláskor / RendszergazdaKábelzár csatlakozóVanJelszavas védelemVan
LENOVO IDEAPAD 320 80XJ000UHV laptop Intel Dual Core i3-6006U, 2.00GHz-es processzorral, 17.3
Jelenlegi ára: 186 900 Ft
Az aukció vége: 2018-10-10 06:04
          LENOVO IDEAPAD 320s 80X5002EHV laptop Intel Dual Core i7-7500U, 3.50GHz-es processzorral, 4GB - Jelenlegi ára: 295 900 Ft      Cache   Translate Page      
Speciális processzor funkciókIntel? Wireless Display (Intel? WiDi)✔ Intel? Smart Response Technology✔ Intel Hyper-Threading Technology (Intel? HT Technology)✔ Intel? Turbo Boost Technology2 Intel? Small Business Advantage (Intel? SBA)✔ Enhanced Intel? SpeedStep Technology✔ Intel? Clear Video HD Technology (Intel? CVT HD)✔ Intel? Clear Video Technology✔ Intel? InTru? 3D Technology✔ Intel? Insider? ✔ Intel? Quick Sync Video Technology✔ Intel? AES New Instructions (Intel? AES-NI)✔ Intel? Enhanced Halt State✔ Intel? VT-x with Extended Page Tables (EPT)✔ Intel? Secure Key✔ Intel? OS Guard✔ Intel? Clear Video technológia mobil internet eszközökhöz (Intel CVT for MID)✔ Intel? 64✔ Execute Disable Bit✔ Hőfigyelő technológiák✔ A processzor csomag mérete42 x 24CPU konfiguráció (max. )1 Intel? Virtualization Technology for Directed I/O (VT-d)✔ Intel? Virtualization Technology (VT-x)✔ Processzor ARK ID95451 Intel? Software Guard Extensions (Intel? SGX)✔ Intel? My WiFi Technology (Intel? MWT)✔ Intel? Flex Memory Access✔ Tétlen állapotok✔ Támogatott parancskészletekAVX 2. 0 / SSE4. 1 / SSE4. 2ProcesszorkódSR2ZVGraphics & IMC lithography14 nmAudióHangszóró teljesítménye2 WVideokátyaVideókártya típusaDedikáltVideókártya márkanVidiaVideókártya memória kapacitás2 GBVideókártya memória típusaGDDR5Csatlakozás & PortokPortok1 / 1 / 1 x USB 2. 0KártyaolvasóSDWireless802, 11 ac/a/b/g/nBluetooth verzió4, 1 Általános jellemzőkNumerikus billentyűzet✔ Billentyűzet nyelvMagyar billentyűzetAkkumulátor élettartam3 hEgyébSúly1. 89 kgKialakításTermék színeSzürkeKülső megjelenésVédőtokTermék típusaNotebookKészülékház anyagaAkrilnitril-butadiénsztirol (ABS) / Alumínium / PolikarbonátTömeg és méretekTömeg1, 89 kgSzélesség36, 27 cmMélység25, 2 cmMagasság1, 99 cmSzínszürkeCsatlakozók és csatlakozási felületekHDMI portok mennyisége1 USB 2. 0 portok száma1 USB 3. 0 (3. 1 Gen 1) A típusú portok száma1 USB 3. 0 (3. 1 Gen 1) C típusú portok száma1 USB töltés alvó módban✔ Alvó állapotbeli töltés USB portok1 HDMI-verzió1, 4 AdattárolásTeljes tárolókapacitás1000 GBAdathordozóHDDBeépített kártyaolvasó✔ Telepített merevlemezek száma1 Merevlemez csatolófelületSATA IIIKompatibilis memóriakártyákMMC / SD / SDHC / SDXCFényképezőgépElülső kamera✔ ProcesszorProcesszormodelli7-7500UProcesszormagok száma2 LéptetőH0Tjunction100 °CThermal Design Power (TDP)15 WCache4096 kBA processzor frekvenciája2, 7 GHzA processzor növelési frekvenciája3, 5 GHzProcesszormagok2 Processzorszálak4 A buszrendszer sebessége4 GT/másodpercProcesszor gyorsítótár4 MBA processzor gyorsítótárának típusaSmart CacheProcesszor litográfia14 nmProcesszor üzemmódok64 -bitA processzor kódneveKaby LakeProcesszorgyártóIntel? A PCI Expressz sávok maximális száma12 PCI-expressz csatlakozók verziója3 PCI Express konfigurációk1Konfliktusmentes processzor✔ Busz típusaOPIKonfigurálható alacsony TDP frekvencia800 MhzArchitektúraKaby LakeAlap frekvencia2, 7 GHzTurbo Boost frekvencia3, 5 GHzProcessszorcsalád7. generációs Intel? Core ? i7Processzor típusai7MemóriaMaximális belső memória8 GBBelső memória4 GBMemória típusaDDR4Memória bővítőhelyek1x SO-DIMMFrekvencia2, 133 GHzBelső memória típusaDDR4-SDRAMMemória formatényezőSO-DIMMMaximális belső memória (64 bites)8 GBMemória kialakítása (bővítőhelyek x méret)1Memória kapacitás4 GBSlotok száma1 Elfoglalt slotok1 Memória órajel2133 MhzKépernyőÁtlós képernyő39, 6 cmKépernyőfelbontás1920 x 1080 pixelekHD típusaFull HDMéretarány16 : 9LED háttérvilágítás✔ KijelzőfelületMattPanel típusaIPSKijelzőFényerő220 cd/m? Kijelző átmérő39, 624000040416 cmKijelző technológiaLEDKijelző felületMattFelbontás1920 x 1080Kijelző felbontásFull HDOperációs rendszerOperációs rendszerMicrosoft Windows 10 Home 64bitMerevlemezMerevlemez kapacitása1000 GBFordulatszám5400 fordulat/percTárhely típusaHDDTárolókapacitás1000 GBMerevlemez mérete2, 5000000000091 ? SzoftverTelepített operációs rendszerWindows 10 HomeAz operációs rendszer architektúrája64 -bitTartozékokHálózati vezeték mellékelve✔ Felhasználói kézikönyv✔ AC adapter mellékelve✔ MultimédiaWebkameraHDOptikai egység✔ HangBeépített mikrofon✔ Beépített hangszórók száma2 HangrendszerDolby AudioAkkumulátorAkkumulátor-technológiaLítium-polimer (LiPo)TanúsítványokEnergy Star tanúsítvány✔ EPEAT megfelelésEzüstRoHS megfelelés✔ HálózatBluetooth verzió4. 1BluetoothVanWi-Fi szabványokIEEE 802. 11a / IEEE 802. 11ac / IEEE 802. 11b / IEEE 802. 11g / IEEE 802. 11nWi-Fi✔ TápellátásAC adapter frekvenciája50 / 60 HzAC adapter bemeneti feszültsége100 ? 240 VGrafikaBeépített grafikus adapter✔ Fedélzeti grafikus adapter azonosítója0 x 5916Fedélzeti grafikus adapter DirectX verzió12 Fedélzeti grafikus adapter OpenGL verzió4, 4 Fedélzeti grafikus adapter-modellIntel HD Graphics 620A fedélzeti grafikus adapter alapfrekvenciája300 MhzMaximális fedélzeti grafikus adapter memória32 GBA támogatott kijelzők száma (fedélzeti grafika)3 A fedélzeti grafikus adapter dinamikus frekvenciája (max. )1050 MhzAlaplapProcesszorfoglalatBGA 1356Méretek és súlySúly1. 89 kgBillentyűzetWindows-gombok✔ MutatóeszközÉrintőpadBiztonságJelszavas védelem típusaHDD / Bekapcsoláskor / RendszergazdaKábelzár-bővítőhely típusaKensingtonKábelzár csatlakozóVanJelszavas védelemVan
LENOVO IDEAPAD 320s 80X5002EHV laptop Intel Dual Core i7-7500U, 3.50GHz-es processzorral, 4GB
Jelenlegi ára: 295 900 Ft
Az aukció vége: 2018-10-10 06:04
          LENOVO THINKPAD L570 20J80027HV laptop Intel Dual Core i5-7200U, 3.10GHz-es processzorral, 8GB - Jelenlegi ára: 290 900 Ft      Cache   Translate Page      
KialakításTermék színeFeketeKülső megjelenésVédőtokTermék típusaNotebookTömeg és méretekTömeg2, 38 kgSzélesség37, 7 cmMélység25, 5 cmMagasság (elülső)2, 76 cmmagasság (hátulsó)3, 08 cmSzínfeketeCsatlakozók és csatlakozási felületekEthernet LAN (RJ-45) portok1 VGA (D-Sub) portok száma1 USB 3. 0 (3. 1 Gen 1) A típusú portok száma4 Kombinált fejhallgató/mikrofon port✔ Dokkoló csatlakozó✔ DC-bemeneti jackdugó✔ USB töltés alvó módban✔ Alvó állapotbeli töltés USB portok1 Mini kijelzőportok száma1 AdattárolásTeljes tárolókapacitás1000 GBAdathordozóHDDBeépített kártyaolvasó✔ Telepített merevlemezek száma1 Merevlemez csatolófelületSATA IIIMerevlemez sebessége5400 RPMKompatibilis memóriakártyákMMC / SD / SDHC / SDXCFényképezőgépElülső kamera✔ Az elülső kamera jelformátuma720 pSpeciális processzor funkciókIntel? Wireless Display (Intel? WiDi)✔ Intel? Smart Response Technology✔ Intel Hyper-Threading Technology (Intel? HT Technology)✔ Intel? Turbo Boost Technology2 Intel? Small Business Advantage (Intel? SBA)✔ Enhanced Intel? SpeedStep Technology✔ Intel? Clear Video HD Technology (Intel? CVT HD)✔ Intel? Clear Video Technology✔ Intel? InTru? 3D Technology✔ Intel? Insider? ✔ Intel? Quick Sync Video Technology✔ Intel? AES New Instructions (Intel? AES-NI)✔ Intel? Enhanced Halt State✔ Intel? VT-x with Extended Page Tables (EPT)✔ Intel? Secure Key✔ Intel? OS Guard✔ Intel? Clear Video technológia mobil internet eszközökhöz (Intel CVT for MID)✔ Intel? 64✔ Execute Disable Bit✔ Hőfigyelő technológiák✔ A processzor csomag mérete42 x 24CPU konfiguráció (max. )1 Intel? Virtualization Technology for Directed I/O (VT-d)✔ Intel? Virtualization Technology (VT-x)✔ Processzor ARK ID95443 Intel? Software Guard Extensions (Intel? SGX)✔ Intel? My WiFi Technology (Intel? MWT)✔ Intel? Flex Memory Access✔ Tétlen állapotok✔ Támogatott parancskészletekAVX 2. 0 / SSE4. 1 / SSE4. 2ProcesszorkódSR2ZUGraphics & IMC lithography14 nmAudióHangszóró teljesítménye1, 5 WVideokátyaVideókártya típusaIntegráltVideókártya márkaIntelCsatlakozás & PortokPortok4 x USB 2. 0KártyaolvasóSD / SDHC / SDXC / MMCWireless802, 11 ac/a/b/g/nBluetooth verzió4 Általános jellemzőkNumerikus billentyűzet✔ Billentyűzet nyelvMagyar billentyűzetProcesszorProcesszormodelli5-7200UProcesszormagok száma2 LéptetőH0Tjunction100 CThermal Design Power (TDP)15 WCache3072 kBIntegrált grafikus processzorIntel? HD Graphics 620A processzor frekvenciája2, 5 GHzA processzor növelési frekvenciája3, 1 GHzProcesszormagok2 Processzorszálak4 A buszrendszer sebessége4 GT/másodpercProcesszor gyorsítótár3 MBA processzor gyorsítótárának típusaSmart CacheProcesszor litográfia14 nmProcesszor üzemmódok64 -bitA processzor kódneveKaby LakeProcesszorgyártóIntel? A PCI Expressz sávok maximális száma12 PCI-expressz csatlakozók verziója3 PCI Express konfigurációk1 x 2 x 2 x 1. 1 x 4. 2 x 2. 4 x 1Konfliktusmentes processzor✔ Busz típusaOPIKonfigurálható alacsony TDP frekvencia800 MhzArchitektúraKaby LakeAlap frekvencia2, 5 GHzTurbo Boost frekvencia3, 1 GHzProcessszorcsalád7. generációs Intel? Core ? i5Processzor típusai5MemóriaMaximális belső memória32 GBBelső memória8 GBMemória típusaDDR4Memória bővítőhelyek2x SO-DIMMBelső memória típusaDDR4-SDRAMMemória formatényezőSO-DIMMMemória kialakítása (bővítőhelyek x méret)1 x 8 GBMemória kapacitás16 GBMemória órajel2133 MhzKijelzőKijelző átmérő39, 6240000404 cmKijelző technológiaLEDKijelző felületMattKijelző felbontásFull HDKépernyőÁtlós képernyő39, 6 cmKépernyőfelbontás1920 x 1080 pixelekHD típusaFull HDMéretarány16 : 10LED háttérvilágítás✔ Optikai meghajtóOptikai meghajtó típusaDVD? RWMerevlemezMerevlemez kapacitása1000 GBFordulatszám5400 fordulat/percTárhely típusaHDDTárolókapacitás256 GBMerevlemez mérete2, 5 ? Operációs rendszerOperációs rendszerFree DOSSzoftverTelepített operációs rendszerFreeDOSTartozékokHálózati vezeték mellékelve✔ AC adapter mellékelve✔ MultimédiaAudióBeépített hangszórókWebkameraHDOptikai egység✔ HangBeépített mikrofon✔ Beépített hangszórók száma2 AkkumulátorAkkumulátor-technológiaLítium-ion (Li-ion)Akkumulátorcellák száma6 Akkumulátor maximális élettartama14, 8 óAkkumulátor kapacitása (wattóra)48 WhTanúsítványokEnergy Star tanúsítvány✔ RoHS megfelelés✔ HálózatBluetooth verzió4. 1BluetoothVanWi-Fi szabványokIEEE 802. 11acWi-Fi✔ LAN adatátviteli sebesség10 / 100 / 1000 Mbit/sEthernet/LAN csatlakozás✔ GrafikaBeépített grafikus adapter✔ Diszkrét grafikus adapter-modellNem áll rendelkezésreFedélzeti grafikus adapter azonosítója0 x 5916Fedélzeti grafikus adapter DirectX verzió12 Fedélzeti grafikus adapter OpenGL verzió4, 4 Fedélzeti grafikus adapter-modellIntel HD Graphics 620A fedélzeti grafikus adapter alapfrekvenciája300 MhzMaximális fedélzeti grafikus adapter memória32 GBA támogatott kijelzők száma (fedélzeti grafika)3 A fedélzeti grafikus adapter dinamikus frekvenciája (max. )1000 MhzAlaplapProcesszorfoglalatBGA 1356BillentyűzetWindows-gombok✔ Numerikus billentyűzet✔ MutatóeszközThinkPad UltraNavCseppálló billentyűzet✔ BiztonságUjjlenyomat-olvasó✔ Megbízott platform modul (TPM)✔ Jelszavas védelem típusaHDD / Bekapcsoláskor / RendszergazdaKábelzár csatlakozóVanJelszavas védelemVan
LENOVO THINKPAD L570 20J80027HV laptop Intel Dual Core i5-7200U, 3.10GHz-es processzorral, 8GB
Jelenlegi ára: 290 900 Ft
Az aukció vége: 2018-10-10 06:04
          Black Business Bus Tour; Economic Empowerment      Cache   Translate Page      

Donald L. Dowridge of DLD Enterprise, Robin Fuson, candidate for County Judge Group 25 and Jack Gutman, candidate for County Judge Group 8 talk about what makes the Black Business Bus Tour great.

          New comment on Item for Geeklist "Virtual Flea Market for Delivery to BGG.Con 2018"       Cache   Translate Page      

by Grendelxclass

Related Item: Onward to Venus

ir1337 wrote:

Grendelxclass wrote:

25.00 for this and hyperborea


To clarify: Is this an offer of $50 for the pair?


No 25.00 for the pair.
          Σχόλιο στο Παραδόθηκαν στη Συρία οι ρωσικοί πύραυλοι S-300 από tsimuha      Cache   Translate Page      
According to an anonymous source, in the Syrian Arab Republic, after the incident with the IL-20 REAR (September 17, 2018), upgraded radar stations “Gamma-S1M” and “Sky-UM” were delivered to Hmeimim airbase, which will take over duty in the air defense of the Russian Federation The radar of medium and high altitudes entered the Armed Forces of the Russian Federation on state defense orders-2018. They are designed to detect, measure coordinates and tracking at a range of up to 600 km of air targets of various categories – from aircraft to cruise and guided missiles, including small-sized, hypersonic and ballistic. The equipment of the stations allows you to determine the nationality of the object and transmit information to the command center or anti-aircraft complexes. In addition, it is possible to find the sources of interference and determine their location. Calculations of radar stations and automation systems of the air defense connection underwent a training course for working with new models of equipment.
          Study suggests a direct link between screen time and ADHD in teens      Cache   Translate Page      
(Natural News) Adding to the list of health concerns associated with excessive screen time, one study suggests that there could be a link between the length of time teenagers spend online and attention deficit hyperactivity disorder (ADHD). The two-year study, which was published in the Journal of the American Medical Association (JAMA), observed more than 2,500 high school... (Source: NaturalNews.com)
          Inflace ve Venezuele stoupne na 10 miliónů procent, odhaduje MMF - Novinky.cz      Cache   Translate Page      

Novinky.cz


Novinky.cz
V příštím roce se tak dál prohloubí jedna z nejhorších hyperinflačních krizí v moderní historii. MMF už dříve přirovnal současný stav ve Venezuele ke krizi v Německu v roce 1923 či v Zimbabwe před deseti lety. MMF také potvrdil předchozí odhad, podle ...

          Inflace ve Venezuele příští rok stoupne na 10 milionů procent, varuje MMF - Aktuálně.cz      Cache   Translate Page      

Aktuálně.cz


Aktuálně.cz
Jedna z nejhorších hyperinflačních krizí v moderní historie se podle Mezinárodního měnového fondu ještě prohloubí. Nusa Dua (Indonésie) - Míra inflace ve Venezuele příští rok dosáhne deset milionů procent. Ve své dnešní zprávě to uvedl Mezinárodní ...

MMF: Inflace ve Venezuele příští rok stoupne na 10 milionů pct




          Officials: Passenger dead after medical emergency on Delta jet      Cache   Translate Page      
The passenger, 62-year-old Yury Rubel, died of hypertensive cardiovascular disease; the plane returned to Detroit.
          Comentario en CFF 28 Oct 2016 por butterfly      Cache   Translate Page      
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          Comentario en WOD 1 Sept 2015 por inflatable neck pillow travel      Cache   Translate Page      
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          ASUS ZenBook Flip S UX370UA-C4211T laptop Intel Quad Core i7-8550U, 4.00GHz-es processzorral, 8GB - Jelenlegi ára: 476 900 Ft      Cache   Translate Page      
EgyébSúly1. 1 kgKialakításTermék színeSzürkeKülső megjelenésÁtalakítható (sátor)Termék típusaHibrid (2 az 1-ben)Tömeg és méretekTömeg1, 1 kgSzélesség31, 3 cmMélység21, 8 cmMagasság1, 09 cmSzín-Csatlakozók és csatlakozási felületekKombinált fejhallgató/mikrofon port✔ USB 3. 0 (3. 1 Gen 1) C típusú portok száma2 AdattárolásTeljes tárolókapacitás512 GBAdathordozóSSDTelepített SSD-k száma1 SSD meghajtó kapacitása512 GBSSD meghajtó csatlakozófelületeSerial ATA IIIFényképezőgépElülső kamera✔ Speciális processzor funkciókIntel? Identity Protection Technology (Intel? IPT)✔ Intel Hyper-Threading Technology (Intel? HT Technology)✔ Intel? Turbo Boost Technology2 Enhanced Intel? SpeedStep Technology✔ Intel? Clear Video HD Technology (Intel? CVT HD)✔ Intel? Clear Video Technology✔ Intel? InTru? 3D Technology✔ Intel? Quick Sync Video Technology✔ Intel? AES New Instructions (Intel? AES-NI)✔ Intel? Enhanced Halt State✔ Intel? VT-x with Extended Page Tables (EPT)✔ Intel? OS Guard✔ Intel? Clear Video technológia mobil internet eszközökhöz (Intel CVT for MID)✔ Intel? 64✔ Execute Disable Bit✔ Hőfigyelő technológiák✔ A processzor csomag mérete42 x 24CPU konfiguráció (max. )1 Intel? Virtualization Technology for Directed I/O (VT-d)✔ Intel? Virtualization Technology (VT-x)✔ Processzor ARK ID122589 Intel? TSX-NI✔ Intel? Software Guard Extensions (Intel? SGX)✔ Intel? My WiFi Technology (Intel? MWT)✔ Intel? Flex Memory Access✔ Tétlen állapotok✔ Támogatott parancskészletekAVX 2. 0 / SSE4. 1 / SSE4. 2VideokátyaVideókártya típusaIntegráltVideókártya márkaIntelVideókártya memória típusaDDR3Csatlakozás & PortokPortok2 x USB 2. 0Wireless802, 11 acBluetooth verzió4, 1 Általános jellemzőkBillentyűzet nyelvMagyar billentyűzetAkkumulátor élettartam2 hProcesszorProcesszormodelli7-8550UProcesszormagok száma4 Cache8192 kBProcesszorgyártóIntel? ArchitektúraKaby LakeAlap frekvencia1, 8 GHzTurbo Boost frekvencia4 GHzL2-gyorsítótár8Processzor típusai7MemóriaMemória maximális sebessége1, 866 GHzMemória típusaDDR3Frekvencia1, 866 GHzMemória kapacitás8 GBSlotok száma1 Elfoglalt slotok1 Memória mérete8 GBKijelzőKijelző felbontása1920Érintőképernyő✔ Képernyőátló13, 300000000017 ? Kijelző átmérő33, 782000034458 cmKijelző technológiaLEDKijelző felületFényesFelbontás1920 x 1080Kijelző felbontásFull HDKépernyőÁtlós képernyő33, 8 cmKépernyőfelbontás1920 x 1080 pixelekHD típusaFull HDMéretarány16 : 9Érintőképernyő✔ LED háttérvilágítás✔ VideokártyaVideokártya típusaIntegráltOptikai meghajtóOptikai meghajtóMeghajtó nélkülMerevlemezMerevlemez kapacitása512 GBTárhely típusaSSDTárolókapacitás512 GBOperációs rendszerOperációs rendszerMicrosoft Windows 10 Home 64bitSzoftverTelepített operációs rendszerWindows 10 HomeMultimédiaWebkameraHDHangBeépített mikrofon✔ HangrendszerSonicMaster PremiumErgonómia / FormatervezésKijelző típusa13, 3" FULL HD LED / fényesAkkumulátorAkkumulátor-technológiaLítium-polimer (LiPo)Akkumulátorcellák száma2 Akkumulátor maximális élettartama11, 5 óAkkumulátor kapacitása (wattóra)39 WhHálózatBluetooth verzió4. 1BluetoothVanWi-Fi szabványokIEEE 802. 11acWi-Fi✔ AdatátvitelAdatátvitelBluetooth / WlanTápellátásAkkumulátor cellaszáma2 AC adapter eloszlás45 WAC adapter frekvenciája50 / 60 HzAC adapter bemeneti feszültsége100 ? 240 VAC adapter kimeneti feszültsége19 GrafikaBeépített grafikus adapter✔ Diszkrét grafikus adapter-modellNem áll rendelkezésreFedélzeti grafikus adapter azonosítója0 x 5917Fedélzeti grafikus adapter DirectX verzió12 Fedélzeti grafikus adapter OpenGL verzió4, 4 Fedélzeti grafikus adapter-modellIntel UHD Graphics 620A fedélzeti grafikus adapter alapfrekvenciája300 MhzMaximális fedélzeti grafikus adapter memória32 GBA támogatott kijelzők száma (fedélzeti grafika)3 A fedélzeti grafikus adapter dinamikus frekvenciája (max. )1150 MhzAlaplapProcesszorfoglalatBGA 1356Méretek és súlySúly1. 1 kgBillentyűzetWindows-gombok✔ MutatóeszközÉrintőpadBiztonságUjjlenyomat-olvasó✔
ASUS ZenBook Flip S UX370UA-C4211T laptop Intel Quad Core i7-8550U, 4.00GHz-es processzorral, 8GB
Jelenlegi ára: 476 900 Ft
Az aukció vége: 2018-10-31 06:07
          LENOVO THINKPAD L570 20J80027HV laptop Intel Dual Core i5-7200U, 3.10GHz-es processzorral, 8GB - Jelenlegi ára: 290 900 Ft      Cache   Translate Page      
KialakításTermék színeFeketeKülső megjelenésVédőtokTermék típusaNotebookTömeg és méretekTömeg2, 38 kgSzélesség37, 7 cmMélység25, 5 cmMagasság (elülső)2, 76 cmmagasság (hátulsó)3, 08 cmSzínfeketeCsatlakozók és csatlakozási felületekEthernet LAN (RJ-45) portok1 VGA (D-Sub) portok száma1 USB 3. 0 (3. 1 Gen 1) A típusú portok száma4 Kombinált fejhallgató/mikrofon port✔ Dokkoló csatlakozó✔ DC-bemeneti jackdugó✔ USB töltés alvó módban✔ Alvó állapotbeli töltés USB portok1 Mini kijelzőportok száma1 AdattárolásTeljes tárolókapacitás1000 GBAdathordozóHDDBeépített kártyaolvasó✔ Telepített merevlemezek száma1 Merevlemez csatolófelületSATA IIIMerevlemez sebessége5400 RPMKompatibilis memóriakártyákMMC / SD / SDHC / SDXCFényképezőgépElülső kamera✔ Az elülső kamera jelformátuma720 pSpeciális processzor funkciókIntel? Wireless Display (Intel? WiDi)✔ Intel? Smart Response Technology✔ Intel Hyper-Threading Technology (Intel? HT Technology)✔ Intel? Turbo Boost Technology2 Intel? Small Business Advantage (Intel? SBA)✔ Enhanced Intel? SpeedStep Technology✔ Intel? Clear Video HD Technology (Intel? CVT HD)✔ Intel? Clear Video Technology✔ Intel? InTru? 3D Technology✔ Intel? Insider? ✔ Intel? Quick Sync Video Technology✔ Intel? AES New Instructions (Intel? AES-NI)✔ Intel? Enhanced Halt State✔ Intel? VT-x with Extended Page Tables (EPT)✔ Intel? Secure Key✔ Intel? OS Guard✔ Intel? Clear Video technológia mobil internet eszközökhöz (Intel CVT for MID)✔ Intel? 64✔ Execute Disable Bit✔ Hőfigyelő technológiák✔ A processzor csomag mérete42 x 24CPU konfiguráció (max. )1 Intel? Virtualization Technology for Directed I/O (VT-d)✔ Intel? Virtualization Technology (VT-x)✔ Processzor ARK ID95443 Intel? Software Guard Extensions (Intel? SGX)✔ Intel? My WiFi Technology (Intel? MWT)✔ Intel? 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A PCI Expressz sávok maximális száma12 PCI-expressz csatlakozók verziója3 PCI Express konfigurációk1 x 2 x 2 x 1. 1 x 4. 2 x 2. 4 x 1Konfliktusmentes processzor✔ Busz típusaOPIKonfigurálható alacsony TDP frekvencia800 MhzArchitektúraKaby LakeAlap frekvencia2, 5 GHzTurbo Boost frekvencia3, 1 GHzProcessszorcsalád7. generációs Intel? Core ? i5Processzor típusai5MemóriaMaximális belső memória32 GBBelső memória8 GBMemória típusaDDR4Memória bővítőhelyek2x SO-DIMMBelső memória típusaDDR4-SDRAMMemória formatényezőSO-DIMMMemória kialakítása (bővítőhelyek x méret)1 x 8 GBMemória kapacitás16 GBMemória órajel2133 MhzKijelzőKijelző átmérő39, 6240000404 cmKijelző technológiaLEDKijelző felületMattKijelző felbontásFull HDKépernyőÁtlós képernyő39, 6 cmKépernyőfelbontás1920 x 1080 pixelekHD típusaFull HDMéretarány16 : 10LED háttérvilágítás✔ Optikai meghajtóOptikai meghajtó típusaDVD? 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LENOVO THINKPAD L570 20J80027HV laptop Intel Dual Core i5-7200U, 3.10GHz-es processzorral, 8GB
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          Building Maintenance Worker - Hypertec - Montréal, QC      Cache   Translate Page      
Being a general handy man with basic knowledge of plumbing, building repair and painting. The Hypertec Group is a global provider of information technology...
From Indeed - Mon, 10 Sep 2018 18:35:28 GMT - View all Montréal, QC jobs
          The Short List: Northwell Health, City of Hope, Children’s Minnesota, and more      Cache   Translate Page      
Gina Czark, Vice President of Content Management at Northwell Health, discussed how they created their hospital-wide blog and supported it through a hyper-focused social promotion strategy. eHealthcare News >> St. Jude hosted a live lecture on CAR T-cell therapy during the Biden Cancer Community Summit on immunotherapy. Periscope >> In a video that garnered over... Read More >
          Europe needs urgent cybersecurity action      Cache   Translate Page      
Election interference. Fake news. Hyper-partisanship. Ransomware. Denial of service attacks. Cyber-terrorism. Welcome to Europe’s new normal, writes Philippe Cotelle.
          A Look at CNTK v2.6 and the Iris Dataset      Cache   Translate Page      

Version 2.6 of CNTK was released a few weeks ago so I figured I’d update my system and give it a try. CNTK (“Cognitive Network Tool Kit”) is Microsoft’s neural network code library. Primary alternatives include Google’s TensorFlow and Keras (a library that makes TF easier to use), and Facebook’s PyTorch.

To cut to the chase, I deleted by existing CNTK and then installed v2.6 using the pip utility, and then . .

As I write this, I think back about all the effort that was required to figure out how to install CNTK (and TF and Keras and PyTorch). It’s easy for me now, but if you’re new to using neural network code libraries, trust me, there’s a lot to learn ― mostly about all the many things that can go wrong with an installation, how to interpret the error messages, and how to resolve.

OK, back to my post. I ran my favorite demo, classification on the Iris Dataset. My old (written for v2.5) CNTK code ran as expected. Excellent!


A Look at CNTK v2.6 and the Iris Dataset

The real moral of the story is that deep learning with neural network libraries is new and still in a state of constant flux. This makes it tremendously difficult to stay abreast of changes. New releases of these libraries emerge not every free months, or even every few weeks, but often every few days. The pace of development is unlike anything I’ve ever seen in computer science.


A Look at CNTK v2.6 and the Iris Dataset

Additionally, the NN libraries are just the tip of the technology pyramid. There are dozens and dozens of supporting systems, and they are being developed with blazing speed too. For example, I did an Internet search for “auto ML” and found many systems that are wrappers over CNTK or TF/Keras or PyTorch, and that are intended to automate the process pipeline of things like hyperparameter tuning, data preprocessing, and so on.

The blistering pace of development of neural network code libraries and supporting software will eventually slow down (maybe 18 months as a wild guess), but for now it’s an incredibly exciting time to be working with deep learning systems.


A Look at CNTK v2.6 and the Iris Dataset

I suspect that an artist’s style doesn’t change too quickly over time (well, after his/her formative years). Three paintings by an unknown (to me) artist with similar compositions but slightly different styles.


          Offer - Dell PowerEdge R820 Server Limited supply for Rental & Sale Kochi - INDIA      Cache   Translate Page      
Flexible, scalable I/O and storage options with PCI-e 3.0 technology allow you to tailor your network throughput to match your application needs. These hyper-scalable features make the DELL POWEREDGE R820 RACK SERVER a perfect fit for computing, memory-intensive applications and expanding virtual environments. Product Highlights Processor: Intel® Xeon® processor E5-4600 v4 Memory : Up 2400MT/s DDR4, RDIMM, LRDIMM Hard Disk: Up to 16 x 2.5” SATA/SAS SSD, SAS HDD Contact Rental India Name – Chackravarthy (8754542653) Name – Anushree (8971423090) Visit Us: https://shop.rental-india.com/product/dell-poweredge-r820-rack-server-available-on-rental-sale/ Mail Us: enquiry@rental-india.com Mandaveli, Chennai-28.
          Venice: Beatrice Burati Anderson – Water / Mater – Exhibition – Party Photos      Cache   Translate Page      
  Photograph and copyright Manfredi Bellati

Beatrice Burati Anderson – Art Space and gallery
Water / Mater
Maurice Nio - Dark Matter
John Lennon and Yoko Ono – The Bag

Water is the mirror that has the ability to show us what we cannot see. It is a blueprint for our reality, which can change with a single positive thought. All it takes is faith, if you’re open to it.
Masaru Emoto - The Secret Life of Water
The exhibition WATER / MATER featuring works by John Lennon and Yoko Ono and the Dutch architect, designer and artist Maurice Nio, until December 22 at Beatrice Burati Anderson Art Space and Gallery is curated by Beatrice Burati Anderson. It is the second exhibition in the Elements series, an extensive project held once a year as part of the gallery’s exhibition program. Based on theories of the Japanese researcher Masaru Emoto, according to whom water molecules are not just sensitive to physical stimuli but also emotional vibrations, harmonizing when they are exposed to positive input, praise and loving words. An awareness of this truth - that dates back to the days of Hippocrates and now lies at the foundations of homoeopathy - takes shape and is visualized thanks to research carried out by Dr. Emoto, who has photographed water molecules at a temperature of -5° to document how crystals take on wonderful forms or, on the contrary, chaotic and disheveled shapes, according to the words they are exposed to. Bearing in mind that human beings are largely made of water, this vision provides plenty to think about and has notable potential from both a scientific and spiritual perspective in terms of how harmony with nature and the development of human mental faculties can help create a better world.
Maurice Nio – Dark Matter - 2012
Polyester – black Mercedes Benz paint – 17 meter - sculpture
Beatrice Burati Anderson
 - Art Space and Gallery

Corte Petriana, San Polo 1448
www.beatriceburatianderson.com
“Dreams, emotions, plants, stones, but especially animals are part of that 90% dark matter. Animals do not talk. They growl, hiss, whistle, bark. We can hear them, but not understand them. That in itself makes them a mystery. What is more beautiful than staring at an animal that does not say anything? What is more beautiful than an animal that does not communicate and withdraws into its own shadow?”
Maurice Nio

Maurice Nio presents Dark Matter, an important 17-metre sculpture taken as a metaphor for the uncontrollable forces of Nature. The work is placed on sand bags, which have conventionally been used to provide protection against water in case of flooding, to evoke the twin potential inherent in this natural element, here presented as “mother water” but always possessing destructive powers. Video clips and architectural projects are also on display highlighting Nio’s distinctive approach that always treats reality as including invisible elements, alongside a formal bond between his architecture and the various shapes of water. Nio the architect is, in fact, a firm believer in Masaru Emoto’s theories as explained in his book SupraSensitivity in Architecture.

John Lennon – Bag One
John Lennon and Yoko Ono

Yoko Ono and John Lennon were evidently aware of the fact that the world can only be changed by spreading loving vibrations by all means available and, indeed, they focused their human and artistic lives around this awareness. Even today aged over eighty, Yoko Ono keeps on conveying thoughts and words of love and peace to the world every day through all the available channels (from art to social networks). The exhibition features the legendary Bag One: a collection of fourteen erotic lithographs – including the famous Bed-in for the peace in the world– that John made on his honeymoon and gave to Yoko as a wedding present, here kindly on loan from Rolando Giambelli’s private collection, the founder and president of The Beatles People Association of Italy.

 
Beatrice Burati Anderson, Concita De Gregorio, Rolando Giambelli,  Karole Vail

 
Alberto Fortis

 
Ewa Morgan, Andrew Huston and Susan Kleinberg


Maurice Nio – The Pecci Files - 2018
10 panel – Plexiglas – technical drawings – Pecci Center – Prato


Cara Kavanaugh

 
Albrecht Pischel and Nataliya Chernakova



Fiorella Mancini

  
Maurice Nio – Dark Matter – 2012 – detail

“We live in a world that is becoming more and more transparent. Riddles are being solved, secrets uncovered, irregularities glossed over, twists rationalized: the other becomes the same. At the point of complete transparency, we end up in a state of complete obscenity as well. After all, when all veils are gone, we are left with nothing but trivial nudity. The temptation has disappeared.  At the same time, however, there is the awareness that 90% of our universe consists of dark matter. Matter that could well be the cause of many incomprehensible phenomena in the universe. If you apply this hypothesis to our world that would mean that fortunately only 10% could really be transparent and obscene. So let us search for the rest, for that 90% dark matter.”
Maurice Nio


Federica Marangoni, Maurice Nio, Maria Grazia Rosin and Patrick Carroll


 Anthony Anderson

 
Lucia Veronesi



Alessio Benetti

 
John Lennon – Bag One
John Lennon and Yoko Ono

 
Alessandra Vio and Cat Bauer

 
 Simone Pellegrini and Alena Tonelli


Jasmine Hellou

 
 Pino