Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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New Haven, Connecticut, Qualifications include a doctoral degree in genetics/epigenetics, statistical genetics, bioinformatics, or other relevant areas. Excellent project management and writing skills are also required. Exce

MiR-155 targeting FoxO3a regulates oral cancer cell proliferation, apoptosis, and DDP resistance through targeting FoxO3a.

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MiR-155 targeting FoxO3a regulates oral cancer cell proliferation, apoptosis, and DDP resistance through targeting FoxO3a.

Cancer Biomark. 2019 Nov 15;:

Authors: Li X, Liu K, Zhou W, Jiang Z

Abstract
FoxO3a is a well-defined tumor suppressor gene in the forkhead transcription factor O subfamily (FoxO), and its reduction is related to the occurrence of various tumors. It was found that the expression of miR-155 is abnormally elevated in oral cancer tissues, suggesting that miR-155 may be a tumor-promoting gene for oral cancer. Bioinformatics analysis revealed a targeted complementary binding site between miR-155 and FoxO3a. In this study, we established a cisplatin-resistant cell line of oral cancer to compare the expression of miR-155 and FoxO3a in parental oral cancer cells, and explore whether miR-155 regulates the expression of FoxO3a and affects the proliferation and apoptosis of oral cancer cells. Dual luciferase reporter gene assay validated the targeted regulatory role between miR-155 and FoxO3a. The DDP-resistant oral cancer cell line KB/DDP was established, and the expressions of miR-155 and FoxO3a were compared. The CCK-8 assay was used to calculate the resistance index (RI). KB/DDP cells were divided into miR-NC group and miR-155 inhibitor group. Cell apoptosis was detected by flow cytometry. Cell proliferation ability was detected by EdU staining. There is a targeted regulatory relationship between miR-155 and FoxO3a mRNA. The expression of miR-155 was significantly higher, while the expression of Foxo3a mRNA and protein was obviously lower in KB/DDP cells than that in KB cells. CCK-8 experiments showed that the same concentration of DDP exhibited apparently lower proliferation inhibition in KB/DDP cells than KB cells. Compared with the miR-NC group, transfection of miR-155 inhibitor markedly increased the expression of Foxo3a in KB/DDP cells, which significantly attenuated cell proliferation and enhanced apoptosis in DDP-treated cells. Increased expression of miR-155 and decreased expression of Foxo3a were associated with DDP resistance in oral cancer cells. Inhibition of miR-155 expression upregulated Foxo3a expression, restrained oral cancer cell proliferation, promoted cell apoptosis, and enhanced DDP sensitivity in oral cancer cells.

PMID: 31771044 [PubMed - as supplied by publisher]

Agilent Receives Multiple Life Science Industry Awards for Innovation

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Agilent Technologies, Inc. (NYSE: A) announced today that it has received two Life Science Industry Awards (LSIA) for 'Most Innovative New Products in 2019' from BioInformatics Inc. Since 2002, the LSIA have recognized manufacturers of the 'tools of science' that help advance biological research and drug discovery. The Agilent products were the Magnis NGS Prep System, which received a Silver Award in the genomics category, and the xCELLigence RTCA eSight, which received a Bronze Award...

Read the full story at https://www.webwire.com/ViewPressRel.asp?aId=250698

Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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Top 15 Deep Learning Applications In 2020 | Deep Learning - Robots.net

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Machine learning applications have gained popularity over the years and now, incorporated with advanced algorithms has been introduced, deep learning applications, as Robots.net reports.

Photo: Gerd Altmann on Pixabay

It may have evolved quickly but deep learning applications have been getting more attention compared to other machine learning applications. But what sets it apart from a machine learning application?

What Is Deep Learning?
Deep learning is an artificial intelligence that mimics the workings of a human brain in processing different data, creating patterns and interpreting information that is used for decision making. It is a subfield of machine learning in artificial intelligence. Its networks has the capability to learn, supervised or unsupervised, from data that is either structured or labelled...

Types Of Deep Learning

There are two types of deep learning, supervised and unsupervised. Supervised learning is when you give an AI a set of input and tell it the expected results. Basically, if the output generated is wrong, it will readjust its calculation and will be done repeatedly over the data set until it makes no more mistakes. Unsupervised learning is the process of machine learning using data sets with no structure specified.

Applications of deep learning have been applied to several fields including speech recognition, social network filtering, audio recognition, natural language processing, machine translation, bioinformatics, computer design, computer vision, drug design, medical image analysis, board games programs and material inspection where they need to produce results that are comparable to or superior to human experts.

Let’s go over more details on applications of deep learning and what can deep learning do.

Read more...

Source: Robots.net

Ofertas de trabajo

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Perfiles que se precisan: Head of Computing and Control Division. Deadline: 30 Nov., 2019 Front-End Developer. New deadline: 29 Nov, 2019 Computational Biologist – Single Cell Genomics. Deadline: 1st Dec, 2019 Bioinformatician at Molecular Pathology of Lymphoid Neoplasms Research Group (Convocatòria ID-127/2019). Deadline: 30 Nov, 2019 Bioestadístic/a en Grup de Recerca Sida i […]

La entrada Ofertas de trabajo se publicó primero en Informatica ++.

Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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Continuous and Discrete Time Signals and Systems with CD-ROM

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This textbook presents an introduction to the fundamental concepts of continuous-time (CT) and discrete-time (DT) signals and systems, treating them separately in a pedagogical and self-contained manner. Emphasis is on the basic signal processing principles, with underlying concepts illustrated using practical examples from signal processing, multimedia communications, and bioinformatics. Following introductory chapters, the text is separated into two parts. Part I covers the theories, techniques, and applications of CT signals and systems and Part II discusses these topics for DT, so that the two can be taught independently or together. Accompanying the book is a CD-ROM containing MATLAB code, audio clips, images, interactive programs, and signal animations. With over 300 illustrations, 285 worked examples and 385 homework problems, this textbook is an ideal introduction to the subject for undergraduates in electrical and computer engineering. Further resources, including solutions for instructors, are available online at www.cambridge.org/9780521854559. Read more...

Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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Comparative Network Pharmacology Analysis of Classical TCM Prescriptions for Chronic Liver Disease

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Chronic liver disease (CLD) has become a major global health problem while herb prescriptions are clinically observed with significant efficacy. Three classical Traditional Chinese Medicine (TCM) formulae, Yinchenhao Decoction (YCHT), Huangqi Decoction (HQT), and Yiguanjian (YGJ) have been widely applied in China to treat CLD, but no systematic study has yet been published to investigate their common and different mechanism of action (MOA). Partial limitation may own to deficiency of effective bioinformatics methods. Here, a computational framework of comparative network pharmacology is firstly proposed and then applied to herbal recipes for CLD disease. The analysis showed that, the three formulae modulate CLD mainly through functional modules of immune response, inflammation, energy metabolism, oxidative stress, and others. On top of that, each formula can target additional unique modules. Typically, YGJ ingredients can uniquely target the ATP synthesis and neurotransmitter release cycle. Interestingly, different formulae may regulate the same functional module in different modes. For instance, YCHT and YGJ can activate oxidative stress-related genes of SOD family while HQT are found to inhibit SOD1 gene. Overall, our framework of comparative network pharmacology proposed in our work may not only explain the MOA of different formulae treating CLD, but also provide hints to further investigate the biological basis of CLD subtypes.

Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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vB_PaeM_MIJ3, a Novel Jumbo Phage Infecting Pseudomonas aeruginosa, Possesses Unusual Genomic Features

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Phages are the most abundant biological entity on Earth. There are many variants in phage virion sizes, morphology, and genome sizes. Large virion sized phages, with genome sizes greater than 200 kbp have been identified and termed as Jumbo phages. These phages exhibit certain characteristics that have not been reported in phages with smaller genomes. In this work, a jumbo phage named MIJ3 (vB_PaeM_MIJ3) that infects Pseudomonas aeruginosa PAO1 was isolated from an equine livery yard in Leicestershire, United Kingdom. The genome and biological characteristics of this phage have been investigated. MIJ3 is a Myovirus with multiple long tail fibers. Assessment of the host range of MIJ3 revealed that it has the ability to infect many clinical isolates of P. aeruginosa. Bioinformatics analysis of the phage genome indicated that MIJ3 is closely related to the Pseudomonas phage, PA5oct. MIJ3 possesses several unusual features that are either rarely present in other phages or have not yet been reported. In particular, MIJ3 encodes a FtsH-like protein, and a putative lysidine synthase, TilS. These two proteins have not been reported in phages. MIJ3 also possesses a split DNA polymerase B with a novel intein. Of particular interest, unlike other jumbo phages infecting Pseudomonas spp., MIJ3 lacks the genetic elements required for the formation of the phage nucleus, which was believed to be conserved across jumbo Pseudomonas phages.

7 (Biomatters Ltd, Auckland, New Zealand) and BioEdit sequence al

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7 (Biomatters Ltd, Auckland, New Zealand) and BioEdit sequence alignment editor (available at http://www.ctu.edu.vn/~dvxe/Bioinformatic/Software/BioEdit.htm). Sequencing results from this study, which included sequences from several A. fumigatus isolates and from ten strains of section Fumigati, were added to a final database … Continue reading →

Computational Biologist / Bioinformatics Scientist - Aperiomics, Inc - Sterling, VA

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PhD degree in bioinformatics, computational biology, computer science, or related discipline or MS degree plus at least 2 years of experience.
From Indeed - Tue, 12 Nov 2019 20:20:35 GMT - View all Sterling, VA jobs

Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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JABAWS 2.2 – JAva Bioinformatics Analysis Web Services

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JABAWS 2.2 :: DESCRIPTION JABAWS is a collection of web services for bioinformatics, and currently provides services that make it easy to access well-known multiple sequence alignment and protein disorder prediction programs from Jalview. JABAWS is free software which provides web services conveniently packaged to run on your local computer, server, cluster or Amazon EC2 … Continue reading

Bioinformatics Faculty - West Liberty University - West Liberty, WV

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Successful candidates will have experience using and administrating Linux/UNIX systems and will have programming experience in statistical programming…
From West Liberty University - Tue, 29 Oct 2019 18:06:28 GMT - View all West Liberty, WV jobs

I Jornada Alumni - Màster de Bioinformàtica i Bioestadística

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Espacio Movistar, Plaça de Catalunya, Barcelona, Espanya

El proper dimarts 17 de desembre a les 17h tindrà lloc la I Jornada Alumni del Màster de Bioinformàtica i Bioestadística UOC-UB, organitzada pels Estudis d'Informàtica, Multimèdia i Telecomunicació de la UOC. La Jornada es celebrarà a l'Espai Movistar de Plaça de Catalunya nº 14, de Barcelona.

L'objectiu és crear un punt de trobada de titulats del Màster Universitari en Bioinformàtica i Bioestadística, i oferir un espai de networking entre titulats i empreses. Durant la Jornada també volem donar visibilitat als nostres titulats i als Treballs Finals que han realitzat ala titulació.

Es tracta d'un punt de trobada entre els titulats del Màster i el sector. L'acte està obert a estudiants, docents i investigadors.

L'acte es celebrarà en castellà i es retransmetrà també en streaming. La inscripció és gratuïta i les places són limitades.

Si hi vols assistir per streaming, has de fer també la inscripció i t'enviarem l'enllaç un dia abans de la jornada.

Amb la col·laboració de:

Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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Scientists develop method to standardize genetic data analysis

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MIPT researchers have collaborated with Atlas Biomedical Holding and developed a new bioinformatics data analysis method. The developed program, EphaGen, can be used for quality control when diagnosing genetic diseases.

Arriva la bioinformatica, nuova frontiera per contrastare il cancro

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Bioinformatics Engineer

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European Molecular Biology Laboratory (EMBL)<br />Salary: Grade 4,5 or 6; depending on experience and qualifications

An Introduction Bioinformatics Algorithms Solution

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An Introduction Bioinformatics Algorithms Solution

Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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EMBL: Software Engineer - Bioinformatics

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Competitive Salary: EMBL: Software Engineer - Bioinformatics Location: Cambridge, Cambridgeshire, England

Bioinformatic Post-doctoral Associate position at Yale School of Medicine, Department of Psychiatry | Ke Xu

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RNA Sequencing; as accurate as once believed?

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Once hailed as the most accurate way to measure gene expression, RNA sequencing’s reproducibility has now been called in to...

The post RNA Sequencing; as accurate as once believed? appeared first on BioTechniques.

Healthcare: Scientist/Senior Scientist, Clinical Biomarkers - Cambridge, Massachusetts

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Scientist/Senior Scientist, Clinical Biomarkers Location Agios Pharmaceuticals HQ Job Code 884 # of openings 1 Apply Now Scientist/Senior Scientist, Clinical Biomarkers Agios (agios.com) is a biopharmaceutical company committed to applying our scientific leadership in cellular metabolism to transform the lives of patients with cancer and rare genetic diseases. We are growing rapidly with an active research and discovery pipeline across both therapeutic areas. Agios has two approved oncology precision medicines and multiple first-in-class investigational therapies in clinical and/or preclinical development. Agios Pharmaceuticals is searching for a dynamic Biomarker Scientist/Sr. Scientist to join our growing Clinical Biomarkers team. The successful candidate will focus on hematological studies in oncology ranging from preclinical to late stage clinical trials often with a focus in epigenetics. The candidate will develop into a lead biomarker role, be responsible for biomarker strategies, and deliver on objectives. This role bridges the science and technical aspects of biomarker strategy with the operational aspects to execute on clinical studies and enable Agios' precision medicine approach. Key Responsibilities Oversee implementation of biomarkers for patient identification, demonstration of mechanisms of action, and for clinical effect to facilitate development in a resource and time efficient manner. Partner closely with Clinical Operations, Biometrics, and Bioinformatics to ensure that biomarker sample collection, assays and data acquisition for analyses are valid and compliant. Develop translational biomarker strategy by incorporating the latest research findings and cutting-edge technologies. Direct and oversee the outsourcing and validation of clinically applicable biomarker assays. Generate/review biomarker reports summarizing study findings and contribute to clinical documents such as protocols, investigator brochures and regulatory submissions. Communicate biomarker data and strategy through in internal and external settings, including publication in high-quality scientific, technical or medical journals. Ensure effective cross functional interactions and collaborations across the different functional areas that relate to Biomarker discovery and development. Minimum Requirements PhD in cancer biology, molecular biology, genomics or related discipline with 3-5 years' experience in the biotech/biopharmaceutical industry, MS with 8+ years. Familiarity managing clinical trial samples, in addition to utilizing genomics, proteomics, and flow cytometry to evaluate drug effects on clinical endpoints Experience in oncology clinical development with patient selection, PD and response biomarker clinical translation Strong background in cancer biology and biomarkers, knowledge in immunotherapy and/or immuno-oncology is a plus Experience with clinical study design and clinical drug development CRO management and clinical site training Record of cutting edge research and/or clinically-related science as evidenced by first- or senior-authored publications in top-tier journals ()

Assistant Bioinformatics Coordinator, Genome Sciences Centre - BC Cancer Research

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